The emerging role of microRNA-126 as a potential therapeutic target in cancer: a comprehensive review

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154631 - 154631

Published: June 20, 2023

Language: Английский

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<b>CRISPR-Based Functional Genomics in Antiviral Innate Immune Response</b>

Journal of Biomedicine and Biochemistry, Journal Year: 2025, Volume and Issue: 4(1), P. 27 - 39

Published: March 26, 2025

CRISPR (clustered regularly interspaced short palindromic repeats)-based genome-wide functional genomics can be applied to uncover novel genes controlling an antiviral immune response, thereby augmenting immunity. To date, much progress has been made in understanding the host and viral factors influencing response since its discovery. However, many of contributing genetic for an- tiviral remain uncharacterized. Using innate immu- nity as a model, this study reports first ge- nomic approach using integrated lentivirus CRISPR-based gene knock- out (GeCKO) screening library identify critical influenc- ing response. This genomic regime is intended enhance pathways broaden use methodologies research therapeutic innovations. The scope answer questions regarding how immunity fights off infections. Two hypotheses are investigated experimentally that key induction interferon found perturbation will reveal network previously uncharacterized With systemic comprehen- sive efforts dissect host-virus molecular arms race, more nuanced acquired, including discovery involved

Language: Английский

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Peptide-Based Therapeutics in Cancer Therapy

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(10), P. 2679 - 2696

Published: Sept. 28, 2023

Language: Английский

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Targeting of CD38 and other NAD-dependent Enzymes in Leukemia Patients

Journal of Biomedicine and Biochemistry, Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Background Leukemia is a type of cancer that affects the blood and bone marrow. This paper highlights role nicotinamide adenine din- ucleotide (NAD) consuming enzymes such as CD38, PARP1, SIRT1 in patients with acute lymphocytic leukemia, myeloid suffering from chronic leukemia.Materials methods Based on recent data. 40 leukemia (ALL), (AML), 30 (CML), healthy persons served controls. The enzyme-linked immunosorbent assay (ELISA) sandwich technique was used to detect serum levels SIRT1.Results In patient, groups compared control group, CD38 con- centrations were discovered be considerably higher (p < 0.05), especially CML also Comparing patient it amounts PARP1 greater When groups' concentrations greater, AML group 0.05).Conclusion results obtained show there reliable correla- tion between NAD-dependent are considered predictive indicators pathological condition can future treatments.

Language: Английский

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Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy

Indian Journal of Clinical Biochemistry, Journal Year: 2024, Volume and Issue: 40(2), P. 165 - 175

Published: Jan. 8, 2024

Language: Английский

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