Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders DOI Creative Commons
Alexander V. Sirotkin, Abdel Halim Harrath

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2405 - 2405

Published: Oct. 21, 2024

Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, ability to act antioxidant, reduce inflammation, and inhibit the growth cancer cells. The purpose this review provide a summary existing knowledge regarding effects apigenin on female reproductive systems dysfunctions. can influence processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, renewal viability, ovarian blood supply, release hormones. It could stimulate folliculogenesis, well embryonal proliferation which lead increase fertility hormones, may exert health. Furthermore, activities cells alleviate pathological changes system caused environmental pollutants, harmful medications, cancer, polycystic syndrome, ischemia, endometriosis. Therefore, have potential biostimulator therapeutic agent certain diseases.

Language: Английский

FORMULATION OF ANDALAS TWIG (MORUS MACROURA MIQ.) EXTRACT LOTION AND EVALUATION OF ITS ACTIVITY DOI Open Access

OTI MUDIA PUSPA,

MOH. ARIF FENDI FERDIA,

Ulfah Nurjanah

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 112 - 118

Published: Feb. 24, 2025

Objective: Indonesia has a relatively high UV exposure, which can cause skin damage, including premature aging through oxidative stress. Andalas twig (Morus macroura Miq.) antioxidant and anti-inflammatory compounds that have great potential to protect the from damage. This study aims formulate lotion extract observe activity reduce impact of due extreme UV-B exposure. Methods: twigs were macerated with ethanol 70% tested using DPPH method. The was then formulated in dosage form at concentrations F1 (1%), F2 (3%), F3 (5%). evaluated for its properties 14 days. Histological examination Mus musculus l male balb/c strain under microscope also done determine on day one 21 treatment. Descriptive analysis carried out interpret histological results. Results: yielded 4% an IC50 value 339.31 ppm DPPH. Based observation, all formulas yellowish-white color, homogenous, pH range 6-7. assessment didn't show collagen formation as effect activity. Still, it showed stress protective repair effects F2. Meanwhile, cell poly-variation, indicating chronic inflammation. Conclusion: Lotion did not but concentration 3% (F2) relieve symptoms. observed may be attributed bioactive within extract, highlighting therapeutic potential. Further research is recommended confirm tree extracts validate their health benefits.

Language: Английский

Citations

0
A comprehensive review on rice responses and tolerance to salt stress DOI Creative Commons

Obed Kweku Sackey,

Naijie Feng, Y A Mohammed

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

The challenge of salinity stress significantly impacts global rice production, especially in coastal and arid regions where the salinization agricultural soils is on rise. This review explores complex physiological, biochemical, genetic mechanisms contributing to tolerance (Oryza sativa L.) while examining agronomic multidisciplinary strategies bolster resilience. Essential adaptations encompass regulation ionic balance, management antioxidants, adjustments osmotic pressure, all driven by genes such as OsHKT1;5 transcription factors like OsbZIP73. evolution breeding strategies, encompassing traditional methods cutting-edge innovations, has produced remarkable salt-tolerant varieties FL478 BRRI dhan47. advancements this field are enhanced including integrated soil management, crop rotation, chemical treatments spermidine, which through antioxidant activity transcriptional mechanisms. Case studies from South Asia, Sub-Saharan Africa, Middle East and, Australia demonstrate transformative potential utilizing varieties; however, challenges persist, polygenic nature tolerance, environmental variability, socioeconomic barriers. highlights importance collaborative efforts across various disciplines, merging genomic technologies, sophisticated phenotyping, inclusive practices foster climate-resilient sustainable cultivation. work seeks navigate complexities its implications for food security, employing inventive cohesive confront posed climate change.

Language: Английский

Citations

0
Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders DOI Creative Commons
Alexander V. Sirotkin, Abdel Halim Harrath

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2405 - 2405

Published: Oct. 21, 2024

Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, ability to act antioxidant, reduce inflammation, and inhibit the growth cancer cells. The purpose this review provide a summary existing knowledge regarding effects apigenin on female reproductive systems dysfunctions. can influence processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, renewal viability, ovarian blood supply, release hormones. It could stimulate folliculogenesis, well embryonal proliferation which lead increase fertility hormones, may exert health. Furthermore, activities cells alleviate pathological changes system caused environmental pollutants, harmful medications, cancer, polycystic syndrome, ischemia, endometriosis. Therefore, have potential biostimulator therapeutic agent certain diseases.

Language: Английский

Citations

1