Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease DOI Creative Commons
Melvin R. Hayden, Neetu Tyagi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1741 - 1741

Published: Dec. 23, 2024

Late-onset Alzheimer’s disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative that associates with aging highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for use sodium thiosulfate (STS) as possible multi-targeting treatment option LOAD. Sulfur widely available environment responsible forming organosulfur compounds are known to be associated wide range biological activities brain. STS have (i) antioxidant (ii) anti-inflammatory properties; (iii) chelation properties calcium pro-oxidative cation metals such iron copper; (iv) donor hydrogen sulfide production; (v) restorative brain endothelial-cell-derived bioavailable nitric oxide. Thus, it becomes apparent has potential neuroprotection neuromodulation may allow an attenuation nature neurodegeneration impaired cognition been successfully used prevent cisplatin oxidative-stress-induced ototoxicity head neck solid cancers, cyanide arsenic poisoning, fungal skin diseases. Most recently, intravenous become part plan calciphylaxis globally due vascular calcification ischemia-induced necrosis ulceration. Side effects minimal reports metabolic acidosis increased anion gap; any drug treatment, there also possibility allergic reactions, long-term osteoporosis from animal studies date, minor side-effects nausea, headache, rhinorrhea if infused too rapidly. While poorly penetrates intact blood–brain barrier(s) (BBBs), could readily penetrate BBBs dysfunctional disrupted deliver its neuroprotective neuromodulating addition ability blood–cerebrospinal fluid barrier choroid plexus. Novel strategies future nano-technology helpful allowing entry into

Language: Английский

Narrowings of the Deep Cerebral Perforating Arteries Ostia: Geometry, Structure, and Clinical Implications DOI Creative Commons
Radosław Rzepliński, Sylwia Tarka, Michał Tomaszewski

et al.

Journal of Stroke, Journal Year: 2025, Volume and Issue: 27(1), P. 52 - 64

Published: Jan. 31, 2025

The pathogenesis of neurovascular diseases and various types dementia is tightly connected to cerebral circulation. An area that requires further exploration the system deep perforating arteries-arteries branching directly from high-pressure intracranial arteries, supplying vital neural structures such as internal capsule, characterized by a diameter well below 1 mm, which makes them difficult visualize with standard radiological examinations. This study aimed analyze morphology perforator origins, constitute connection points between arteries microcirculation. Twenty-three human basal ganglia specimens middle artery (MCA, including 172 arteries) ten brainstem basilar (BA, 162 were prepared scanned using microcomputed tomography. geometry structure analyzed images additional histological studies. ostia ellipsoidal in shape median stenosis severity 23% 20% for MCA BA perforators, respectively. local narrowing was typical neointimal hyperplasia. Statistical analysis revealed may be related age cardiovascular health. Origins perforators are locally narrowed hyperplasia, protective mechanism adjust high blood pressure narrowings lead chronic hypoperfusion play role pathophysiology small vessel disease.

Language: Английский

Citations

1
Analysis of CT characteristics and prognostic factors in non-hypertensive cerebral hemorrhage DOI

Sai Liang,

Qin Yan, Wei Lu

et al.

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(1), P. 101302 - 101302

Published: Jan. 28, 2025

Language: Английский

Citations

0
Vascular and glymphatic dysfunction as drivers of cognitive impairment in Alzheimer's disease: Insights from computational approaches DOI Creative Commons

Gehan Fatima,

Akm Ashiquzzaman,

Sang Seong Kim

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106877 - 106877

Published: March 1, 2025

Language: Английский

Citations

0
Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy DOI Creative Commons
Li Zhao, Lingyun Liu, Lin Miao

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 22, 2025

Objectives To investigate whether cerebrospinal fluid (CSF) circulation markers alter in patients with probable cerebral amyloid angiopathy (pCAA) and they are associated brain degeneration cognitive impairment. Methods We screened pCAA from the ADNI3 database according to Boston 2.0 Criteria. Fifty-two impairment (26 pCAA; 26 age-sex-matched non-pCAA) cognitively normal control (NC) were included this study. All participants underwent neurological MRI assessments. Choroid plexus (ChP) was segmented using a deep learning-based method its volume extracted. Diffusion tensor imaging analysis along perivascular space (DTI-ALPS) used assess perivenous mobility. AD pathological (Aβ tau) assessed positron emission tomography. Brain parenchymal damage white matter hyperintensities (WMH) atrophy ratio. compared among three groups. Correlations ChP volume, DTI-ALPS index, markers, scales analyzed group. Results The groups exhibited significant differences scores, biomarkers, markers. Post hoc analyses showed that had significantly higher WMH Aβ tau deposition, lower NC. However, no difference ChPs found Controlling for age, sex, vascular risk factors, partial correlation negative between fraction ( r = −0.606, p 0.002). Montreal assessment score −0.492, 0.028). Conclusion CSF elevated burden impairments CAA.

Language: Английский

Citations

0
Automated brain segmentation and volumetry in dementia diagnostics: a narrative review with emphasis on FreeSurfer DOI Creative Commons
Eya Khadhraoui, Thomas Nickl‐Jockschat, Hans Henkes

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 3, 2024

Background Dementia can be caused by numerous different diseases that present variable clinical courses and reveal multiple patterns of brain atrophy, making its accurate early diagnosis conventional examinative means challenging. Although highly powerful, magnetic resonance imaging (MRI) currently plays only a supportive role in dementia diagnosis, largely due to the enormous volume diversity data it generates. AI-based software solutions/algorithms perform automated segmentation volumetry analyses MRI are being increasingly used address this issue. Numerous commercial non-commercial solutions for exist, with FreeSurfer most frequently used. Objectives This Review is an account current situation regarding application diagnosis. Methods We performed PubMed search “FreeSurfer AND Dementia” obtained 493 results. Based on these results, we conducted in-depth source analysis identify additional publications, tools, methods. Studies were analyzed design, patient collective, statistical evaluation (mathematical methods, correlations). Results In studies identified, main cohorts represented Alzheimer’s disease ( n = 276), mild cognitive impairment 157), frontotemporal 34), Parkinson’s 29), Lewy bodies 20), healthy controls 356). The findings methods selection identified summarized discussed. Conclusion Our showed that, while large number available, many underrepresented terms their incidence. There therefore plenty scope targeted research.

Language: Английский

Citations

1
Beta-Amyloid related neurodegenerative and neurovascular diseases: potential implications for transfusion medicine DOI Creative Commons
Ryan T. Muir, Jeannie Callum, Amy Yu

et al.

Transfusion Medicine Reviews, Journal Year: 2024, Volume and Issue: 38(4), P. 150858 - 150858

Published: Sept. 18, 2024

Language: Английский

Citations

1
Paying Homage to Microvessel Remodeling and Small Vessel Disease in Neurodegeneration: Implications for the Development of Late-Onset Alzheimer’s Disease DOI Creative Commons
Melvin R. Hayden

Journal of Vascular Diseases, Journal Year: 2024, Volume and Issue: 3(4), P. 419 - 452

Published: Nov. 20, 2024

The microvessel neurovascular unit, with its brain endothelial cells (BEC) and blood–brain barrier remodeling, is important in the development of impaired cognition sporadic or late-onset Alzheimer’s disease (LOAD), which associated aging highly prevalent older populations (≥65 years age). It also linked vascular dementia contributions to cognitive impairment dementia, including cerebral amyloid angiopathy neurodegeneration. LOAD considered be number one cause globally; however, when considers role mixed (MD)—the combination both cascade hypothesis LOAD—it becomes apparent that MD cause. Microvessel BECs are first exposed peripheral neurotoxins from systemic circulation therefore at highest risk for early chronic injury. Therefore, these undergo injury, followed by excessive recurrent wound healing remodeling processes other age-related diseases such as cerebrocardiovascular disease, hypertension, type 2 diabetes mellitus, Parkinson’s disease. This narrative review explores intricate relationship between small vessel (SVD), neurodegeneration LOAD. discusses current understanding how dysfunction, disruption, pathology contribute pathogenesis highlights potential avenues therapeutic intervention.

Language: Английский

Citations

1
Early Impairment of Face Perception in Post-Stroke Depression: An ERP Study DOI

Pingshu Zhang,

Lingyun Cao,

J. Yuan

et al.

Clinical EEG and Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Face recognition is an important cognitive function of the human brain. Post stroke depression (PSD) a common mental complication after stroke, which has serious impact on individual physical recovery and quality life. This study aims to explore face perception characteristics PSD through electrophysiological indicators N170 VPP, provide objective basis for early evaluation facial dysfunction in PSD.

Language: Английский

Citations

0
A Mendelian Randomization Study about Causal Associations between Tofu Consumption and Stroke as well as Related Subtypes DOI Creative Commons
Yan Wang, Yunlong Liu, Mingwu Xia

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(11)

Published: Oct. 30, 2024

Objective: Consuming soy in the diet is beneficial for health, and tofu possess richest source of dietary soy. However, specific association with stroke related subtypes remains controversial. In this study, genetic causal relationship among as well was investigated by utilizing data a number genome-wide study (GWAS) based on population. Methods: The intake GWAS analysis derived from Medical Research Council (MRC) Integrative Epidemiology Unit at University Bristol (MRC-IEU) Consortium. two-sample Mendelian randomization (MR) carried out, multiple methods to analyze associations subtypes. sensitivity, heterogeneity, potential pleiotropy could be method. Results: We found that had no stroke. subtype, there risk intracerebral hemorrhage (ICH) (odds ratio, OR = 1.24 × 10-5, 95% CI: 1.54 10-8–9.95 10-3, p 9.300 10-4), while does not affect ischemic (OR 1.07 10-1, 3.84 10-4–2.97 101, 4.362 10-1) subarachnoid (SAH) 3.33 1.79 10-6–6.18, 1.373 10-1). Both PRESSO (MR-PRESSO) global test Cochran's Q did detect any sensitivity heterogeneity. Conclusions: While consumption associated higher ICH, it show significant or SAH. varying effects different underscore need considering confounding lifestyle factors future studies.

Language: Английский

Citations

0
Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s Disease DOI Creative Commons
Melvin R. Hayden, Neetu Tyagi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1741 - 1741

Published: Dec. 23, 2024

Late-onset Alzheimer’s disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative that associates with aging highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for use sodium thiosulfate (STS) as possible multi-targeting treatment option LOAD. Sulfur widely available environment responsible forming organosulfur compounds are known to be associated wide range biological activities brain. STS have (i) antioxidant (ii) anti-inflammatory properties; (iii) chelation properties calcium pro-oxidative cation metals such iron copper; (iv) donor hydrogen sulfide production; (v) restorative brain endothelial-cell-derived bioavailable nitric oxide. Thus, it becomes apparent has potential neuroprotection neuromodulation may allow an attenuation nature neurodegeneration impaired cognition been successfully used prevent cisplatin oxidative-stress-induced ototoxicity head neck solid cancers, cyanide arsenic poisoning, fungal skin diseases. Most recently, intravenous become part plan calciphylaxis globally due vascular calcification ischemia-induced necrosis ulceration. Side effects minimal reports metabolic acidosis increased anion gap; any drug treatment, there also possibility allergic reactions, long-term osteoporosis from animal studies date, minor side-effects nausea, headache, rhinorrhea if infused too rapidly. While poorly penetrates intact blood–brain barrier(s) (BBBs), could readily penetrate BBBs dysfunctional disrupted deliver its neuroprotective neuromodulating addition ability blood–cerebrospinal fluid barrier choroid plexus. Novel strategies future nano-technology helpful allowing entry into

Language: Английский

Citations

0