Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

International Journal of Transgender Health, Journal Year: 2022, Volume and Issue: 23(sup1), P. S1 - S259

Published: Aug. 19, 2022

Transgender healthcare is a rapidly evolving interdisciplinary field. In the last decade, there has been an unprecedented increase in number and visibility of transgender gender diverse (TGD) people seeking support gender-affirming medical treatment parallel with significant rise scientific literature this area. The World Professional Association for Health (WPATH) international, multidisciplinary, professional association whose mission to promote evidence-based care, education, research, public policy, respect health. One main functions WPATH highest standards health care TGD through Standards Care (SOC). SOC was initially developed 1979 version (SOC-7) published 2012. view increasing evidence, commissioned new Care, SOC-8.

Language: Английский

---

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(5), P. 2639 - 2639

Published: March 5, 2021

Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce adipokines, myokines, hepatokines. These biomarkers can be harmful or beneficial to an organism still perform crosstalk, acting through endocrine, paracrine, autocrine pathways. This study aims review crosstalk between Far beyond understanding actions of each biomarker alone, it is important underline these cytokines act together in body, resulting a complex network different tissues, which may have non-beneficial effects on genesis various physiological disorders their respective outcomes, such as type 2 diabetes mellitus (DM2), obesity, metabolic syndrome, cardiovascular diseases (CVD). Overweight individuals secrete more pro-inflammatory adipokines than those healthy weight, leading impaired immune response greater susceptibility inflammatory infectious diseases. Myostatin elevated environments, sharing space with organokines, tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), resistin, chemerin. Fibroblast growth factor FGF21 acts beta-oxidation regulator decreases lipogenesis liver. The mentioned above interfere homeostatic play role potential therapeutic target assist methods diagnosing syndrome CVD.

Language: Английский

---

Dietary antioxidant intake decreases carotid intima media thickness in women but not in men: A cross-sectional assessment in the Kardiovize study

Free Radical Biology and Medicine, Journal Year: 2018, Volume and Issue: 131, P. 274 - 281

Published: Dec. 19, 2018

Language: Английский

---

Hypertriglyceridemia-Associated Pancreatitis: New Concepts and Potential Mechanisms

Clinical Chemistry, Journal Year: 2023, Volume and Issue: 69(10), P. 1132 - 1144

Published: June 15, 2023

Triglycerides are a major source of energy, while high plasma triglycerides risk factor for various diseases and premature death. Severely elevated well-established cause acute pancreatitis with mortality, likely due to the presence levels chylomicrons large very low-density lipoproteins in plasma. As markedly these not generally found mild moderate hypertriglyceridemia, this was previously regarded as or marker increased pancreatitis. However, hypertriglyceridemia may identify individuals who at later timepoint develop severe pancreatitis.We describe measurement studies on Further, we summarize current European American guidelines prevention and, finally, potential future through lowering triglycerides.Recent observational genetic indicate that is causally related pancreatitis, most hypertriglyceridemia. Current do mention even though newer evidence suggests an unmet medical need. Treatment could include triglyceride-lowering therapy targeting pathway lipoprotein lipase main triglyceride degrading enzyme Angiopoietin-like 3 apolipoproteinC-III inhibitors lipase, blocking 2 showing promising results relation marked perhaps be used prevent future.

Language: Английский

---

I Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology

Brazilian Journal of Nephrology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 24, 2025

Abstract Hypertension in dialysis patients (HTND) has a high prevalence, affecting at least 80% or more of patients, and its management the nephrology practice is heterogeneous often empirical. Knowing how to define, understand pathophysiology, diagnose, monitor treat with lifestyle changes, adjust antihypertensive drugs achieve recommended blood pressure (BP) target - reduce morbidity mortality requires specific knowledge approaches within contexts hemodialysis (HD) peritoneal (PD). This document first guideline Brazilian Society Nephrology, developed by departments Dialysis. It aims guide physicians who provide care centers on manage HTND, comprehensive individualized manner, based critical appraisal best available scientific evidence. When such evidence scarce unavailable, opinion specialists should be recommended. The different topics covered include HTND definition (pre-HD BP ≥ 140/90 mmHg post-HD 130/80 mmHg), epidemiology, pathophysiology; diagnosis preferably measurements outside setting (BP mmHg); complementary assessment; targets; non-pharmacological treatment; use most appropriate medications; special situations; complications predominantly cardiovascular ones.

Language: Английский

---

Considerações Especiais na Prevenção de Doenças Cardiovasculares nas Mulheres

Arquivos Brasileiros de Cardiologia, Journal Year: 2022, Volume and Issue: 118(2), P. 374 - 377

Published: Feb. 1, 2022

As doenças cardiovasculares (DCV) são a principal causa de morte e incapacidade no Brasil, em mulheres homens. De acordo com as estimativas do Estudo GBD 2019, entre DCV, doença isquêmica coração (DIC) foi primeira seguida pelo acidente vascular cerebral (AVC). A DIC responsável por 12,03% (II95 10,66%-12,88%) 12,2% 11,5%-12,77%) dos óbitos 4,78% 4,08%-5,47%) 6,48% 5,92%-7,05 %) anos vida ajustados [...]

---

Tackling Atherosclerosis via Selected Nutrition

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8233 - 8233

Published: July 26, 2022

The development and pathogenesis of atherosclerosis are significantly influenced by lifestyle, particularly nutrition. modern level science technology promote personalized nutrition as an efficient preventive measure against atherosclerosis. In this survey, the factors were revealed that contribute to formation individual approach nutrition: genetic characteristics, state microbiota gastrointestinal tract (GIT) environmental (diets, bioactive components, cardioprotectors, etc.). course work, it was found in order analyze predisposition associated with nutrition, features affecting metabolism nutrients significant. include presence single nucleotide polymorphisms (SNP) genes epigenetic factors. influence telomere length on circadian rhythms also considered. Relatively new is study relationship between chrono-nutrition metabolic diseases. That is, obtain atherosclerosis, a large number markers should be relation, question arises: "How many need analyzed form diet for consumer?" Basically, companies engaged nutrigenetic research choosing prevention diseases use SNP analysis accounts lipid metabolism, vitamins, body's antioxidant defense system, taste etc. There no set markers. main diets effective considered, most popular ketogenic, Mediterranean, DASH-diets. advantage these content foods low amount carbohydrates, high vegetables, fruits berries, well rich antioxidants. However, due restrictions climatic, geographical, material features, not available consumers. way out functional products, dietary supplements. approach, promising biologically active substances (BAS) exhibit anti-atherosclerotic potential are: baicalin, resveratrol, curcumin, quercetin other plant metabolites. Among substances, those animal origin popular: squalene, coenzyme Q10, omega-3. For through necessary characteristics nutrients, assess GIT. Based data obtained food preferences, capabilities consumer, optimal can selected. It topical exclude which their excess consumption stimulates occurrence enrich (FF), BAS containing anti-atherosclerotic, stimulating GIT nutrients. Personalized there problems hindering among key weak evidence cost difficulties interpretation results. Eliminating deficiencies will maintenance healthy population

Language: Английский

---

Quality appraisal and descriptive analysis of clinical practice guidelines for self-managed non-pharmacological interventions of cardiovascular diseases: a systematic review

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 29, 2024

Cardiovascular diseases (CVDs) are the leading cause of death around world. Most CVDs-related can be prevented by optimal management risk factors such as unhealthy diet and physical inactivity. Clinical practice guidelines (CPGs) for CVDs, provide some evidence-based recommendations which help healthcare professionals to achieve best care patients with CVDs. This systematic review aims appraise methodological quality CPGs systematically summarize self-managed non-pharmacological interventions prevention CVDs provided selected guidelines.

Language: Английский

---

Urbanization and cardiovascular health among Indigenous groups in Brazil

Communications Medicine, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 2, 2023

Abstract Background We described the prevalence of cardiovascular risk factors in groups Brazilian Indigenous people at different degrees urbanization. Methods The Project Atherosclerosis among populations (Projeto de Aterosclerose em Indígenas; PAI) is a cross-sectional study conducted Northeast Brazil between August 2016–June 2017. It included three populations: Fulni-ô (lowest degree urbanization), Truká (greater and highly urbanized non-Indigenous local cohort (control group). Participants were assessed to register sociodemographic, anthropometric, as well clinical laboratory-derived (CV) parameters. Age-adjusted hypertension was also computed. Nonparametric tests used for group comparisons. Results Here we 999 participants, with predominance females all (68.3% Control group, 65.0% indigenous 60.1% Obesity present 45.6% urban population, 37.7% 27.6% participants. 29.1% ( n = 297) lower less (Fulni-ô – 18.2%; 33.9%; 33.8%; p < 0.001). In elderly male 18.7% Fulni-ô, 45.8% Truká, 54.5% control group. Of 342 participants that self-reported hypertension, 37.5% 68) showed uncontrolled blood pressure (BP). Uncontrolled BP more prevalent when compared (45.4%, 22.9%, 40.7%, respectively; Conclusions found higher communities urbanization, suggesting living towns cities may have negative impact on these aspects health.

Language: Английский

---

Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and Liver Damage in Hypercholesterolemic Rats

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 426 - 426

Published: Jan. 18, 2022

Metabolic syndrome, especially its component related to dyslipidemia, is the development of nonalcoholic fatty liver disease (NAFLD), which a with significant global prevalence. Supplementation omega-3 polyunsaturated acids emerged as complementary therapeutic possibility for but benefits are questioned. This paper aims at evaluating effects fish oil supplementation in rats hypercholesterolemia induced by hypercholesterolemic diet (HD). The study design based on an experimental model animals were randomly divided into 3 groups: G1 (standard commercial feed + saline solution); G2 (hypercholesterolemic solution) and G3 oil) over period 16 weeks. control parameters oxidative stress biomarkers evaluated according standardized methodologies. group showed significantly lower values plasma concentrations TG, hepatic myeloperoxidase well higher erythrocyte superoxide dismutase activity (p < 0.05). Regarding histopathological analysis, there was lipid accumulation from G2; meanwhile, hepatocytes reorganization expressive reduction vacuoles TG content observed G3. demonstrated how reduced concentration triglycerides, tissue damage analysis.

Language: Английский

---