Copper and Photocatalytic Synergistic Strategies for Radical Cyclization Reactions DOI Open Access
Yunpeng Lu,

Nan‐Nan Dai,

M. Li

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(19), P. 4000 - 4016

Published: July 30, 2024

Abstract The rapid development of photo‐synergistic transition metal catalytic systems has provided a green paradigm to complement thermal methods. However, the most commonly used iridium or ruthenium complexes involve expensive in nature, contrast abundant copper elements earth's crust, which are highly valued for their unique electronic structure and light‐absorbing properties. Recently, application photocatalytic synergistic strategies radical cyclization reactions progressed considerably, leading renaissance synthesis functional natural products, drugs analogues, but summary work addressing this aspect not been reported. In review, we briefly analyze effect ligand choice on some inorganic salts even light sources. We then summarize classify them into three categories, C, N O radicals, according class central atom each work, category will be elaborated turn from coordination via Cu catalysts, direct other mode. For individual more complex reactions, mechanisms explored discussed.

Language: Английский

Recent advances in radical-mediated intermolecular (4 + 2) cycloaddition DOI

Xue‐Er Cai,

Ziying Wang,

Wen‐Chan Tian

et al.

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(30), P. 6068 - 6082

Published: Jan. 1, 2023

On the basis of types radicals that initiate different intermolecular (4 + 2) cycloaddition processes, we classify them into five types, and this review places special emphasis on reaction design mechanisms.

Language: Английский

Citations

9
Transition-Metal-Catalyzed Dehydrogenative (3 + 2) Annulation of Aromatic Compounds: Synthesis of Indenes and Indanes via Dual Functionalization of Benzylic and ortho C–H Bonds DOI

Wen‐Qiang Wu,

Hang Shi

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(20), P. 14264 - 14273

Published: Oct. 9, 2023

Intermolecular (3 + 2) annulation emerges as a potent approach for constructing 5-membered carbocycles through the fusion of two distinct components. This synopsis encapsulates recent strides in realm transition-metal-catalyzed dehydrogenative aromatic hydrocarbons, achieved dual functionalization benzylic and ortho C–H bonds. Encompassing three pivotal strategies, namely, (i) bond activation, (ii) oxidation, (iii) π-coordination this review offers an overview field's developments.

Language: Английский

Citations

7
Radical Difunctionalization of Unsaturated Hydrocarbons Employing the Same Functional Reagent DOI

Wen‐Chan Tian,

Nan‐Nan Dai,

Yunpeng Lu

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(17), P. 3524 - 3541

Published: July 3, 2024

Abstract The radical difunctionalization of unsaturated hydrocarbons serves as an efficient means to rapidly construct molecular skeletons and synthesize‐highly valuable compounds. In this transformational process, diverse positions within are sequentially functionalized by a single precursor reagent, thereby achieving highly selective transformations that promote atom economy. Furthermore, approach minimizes the generation numerous byproducts stemming from cross‐coupling reactions between reactants, owing reduction number participating components. Therefore, review provides in‐depth analysis utilizing functional reagent in recent decades. discussion is based on eight different classes (carbon‐, nitrogen‐, phosphine‐, oxygen‐, sulfur‐, selenium‐, tellurium‐, chlorine‐centered radicals), emphasizing mechanism specific difunctionalization. It also analyzes detail regulation key factors such regional selectivity, unique insights into reaction transformations.

Language: Английский

Citations

1
Vinyl radicals in transition metal-catalyzed organic transformations DOI

Mu-Han Li,

Xiao-Rong Shu,

Yue-Jiao Lu

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5202 - 5231

Published: Jan. 1, 2024

We summarize the advancements in transition metal-catalyzed organic transformations involving vinyl radicals and provide a categorical overview based on reaction types.

Language: Английский

Citations

0
Copper and Photocatalytic Synergistic Strategies for Radical Cyclization Reactions DOI Open Access
Yunpeng Lu,

Nan‐Nan Dai,

M. Li

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(19), P. 4000 - 4016

Published: July 30, 2024

Abstract The rapid development of photo‐synergistic transition metal catalytic systems has provided a green paradigm to complement thermal methods. However, the most commonly used iridium or ruthenium complexes involve expensive in nature, contrast abundant copper elements earth's crust, which are highly valued for their unique electronic structure and light‐absorbing properties. Recently, application photocatalytic synergistic strategies radical cyclization reactions progressed considerably, leading renaissance synthesis functional natural products, drugs analogues, but summary work addressing this aspect not been reported. In review, we briefly analyze effect ligand choice on some inorganic salts even light sources. We then summarize classify them into three categories, C, N O radicals, according class central atom each work, category will be elaborated turn from coordination via Cu catalysts, direct other mode. For individual more complex reactions, mechanisms explored discussed.

Language: Английский

Citations

0