Zinc sulphate alleviates olanzapine-induced testicular oxidative stress and alters trace elements in male rats DOI Creative Commons
Hossam Ebaid, Samir A. E. Bashandy, Iftekhar Hassan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 7, 2024

Abstract Male infertility is a complex and multifactorial clinical condition affecting large population attributed to various factors, including perturbation in oxidative stress the level of essential trace elements. Oxidative insults exert multiple issues related reproductive health, male infertility, decreased sperm motility, DNA damage, an increased susceptibility genetic disorders. Besides chemical toxins food allergens junk items, many drugs can also lead fertility. Olanzapine, general antipsychotic drug, has been reported induce A great deal literature entails that zinc alleviate stress-related complications This study investigates potential protective effects sulphate on olanzapine-induced infertility. In present study, there were four treatment groups (n = 6) Group 1 as control (without any treatment); 2 treated with olanzapine (10 mg/kg) orally daily for six weeks; 3 4 50mg/kg 100 mg/kg respectively pre-exposed (10mg/kg) weeks. After completion treatment, biochemical analysis serum tissue samples demonstrated group had compromised levels antioxidant parameters (SOD, CAT GSH) well elevated (GSSG, MDA NO). However, ZnSO4 corrected all these dose-dependent way 4. Other health indicators, like taurine, enzyme Q10, phosphatidylcholine, ascorbic acid, vitamin E, observed improve supplementation ZnSO4. Intriguingly, fertility (sperm count testosterone) found significantly enhanced abnormalities both combination groups. The histological evaluation testis section agreed analysis. Therefore, strongly advocates Zn ameliorate significant extent.

Language: Английский

Extracellular vesicles in reproductive medicines DOI
Karima Mokhtari, Mohsen Sheykhhasan, Mina Shahnazari

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 243 - 281

Published: Jan. 1, 2025

Citations

0
Cytotoxic Properties of Cyclophosphamide: A Focus on Its Mechanistic Impacts on Male Gonadal Functions DOI Open Access
Temitope Gideon Olowe, Mega Obukohwo Oyovwi, Eze Kingsley Nwangwa

et al.

Journal of Exploratory Research in Pharmacology, Journal Year: 2024, Volume and Issue: 9(2), P. 106 - 115

Published: May 11, 2024

Cyclophosphamide (CP) is a potent chemotherapeutic agent utilized in the treatment of various types cancer. However, addition to its efficacy combating cancer, CP also has severe side effects, including damage male gonadal functions. This paper aims explore cytotoxic properties and mechanistic impacts on The search strategy was conducted using several reviewed articles indexed PubMed, Science Direct, EBSCO, Scopus, Cochrane Library, Sage Journals, Google Scholar. an alkylating that damages cancer cell DNA, inhibiting growth division. It affects healthy cells, leading cytotoxicity. In tissues, germ Leydig Sertoli causing decreased sperm count, testosterone levels, disruption blood-testis barrier. metabolism liver generates reactive oxygen species, oxidative death. Moreover, hypothalamic-pituitary-gonadal axis, regulating disrupts production secretion gonadotropin-releasing hormone, follicle-stimulating luteinizing resulting decrease levels impaired spermatogenesis. Additionally, exerts effects by proliferation differentiation production. which are responsible for testosterone, thus decreasing levels. conclusion, exhibits not only affect cells but severely mechanisms involved CP-induced toxicity include stress axis. Therefore, it crucial consider potential when prescribing closely monitor functions patients receiving therapy.

Language: Английский

Citations

2
The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats DOI Creative Commons
Hossam Ebaid, Samir A. E. Bashandy, Iftekhar Hassan

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Male infertility is a complex and multifactorial clinical condition affecting large population attributed to several factors, including perturbation in oxidative stress the level of essential trace elements. Oxidative exerts multiple issues related reproductive health, male infertility, decreased sperm motility, DNA damage, an increased susceptibility genetic disorders. Besides chemical toxins food allergens junk items, many drugs can also lead infertility. Olanzapine (OLZ), general antipsychotic drug, has been reported induce fertility. A great deal literature entails that supplementation zinc alleviate stress–related complications, This study investigates potential protective effects sulfate (ZnSO4) on OLZ-induced In present study, there were four treatment groups ( n = 6): group 1 as control (without any treatment); 2 treated with OLZ (10 mg/kg) orally daily for 6 weeks; 3 4 50 mg/kg 100 ZnSO4 respectively pre-exposed weeks. After completion treatment, biochemical analysis serum tissue samples demonstrated had compromised levels antioxidant parameters (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH)) well elevated (oxidized (GSSG), malondialdehyde (MDA), nitric oxide (NO)) compared by significant extent p ≤ 0.05). However, significantly corrected all these dose-dependent way Other health indicators, like taurine, enzyme Q10, phosphatidylcholine, ascorbic acid, vitamin E, observed improve prominently ZnSO4. Intriguingly, fertility (sperm count testosterone) found be enhanced abnormalities both combination groups. The histological evaluation testis section agreed this investigation. Therefore, strongly advocates Zn ameliorate extent. Graphical Putative mechanism was involved preventive effect against vivo. generates free radicals stress-mediated toxicity target organs testes evidenced alteration markers histology. ions from act agent blunting most OLZ-perturbed redox histology consequently improving parameters.

Language: Английский

Citations

2
Effect of Triclisia subcordata Oliv. (Menispermaceae) leaves on hormonal imbalance and genes expression in the ovaries of letrozole-induced polycystic rats via in vivo and computational approaches DOI
Akingbolabo Daniel Ogunlakin, Oluwafemi Adeleke Ojo, Gideon Ampoma Gyebi

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139275 - 139275

Published: July 11, 2024

Language: Английский

Citations

1
Zinc sulphate alleviates olanzapine-induced testicular oxidative stress and alters trace elements in male rats DOI Creative Commons
Hossam Ebaid, Samir A. E. Bashandy, Iftekhar Hassan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 7, 2024

Abstract Male infertility is a complex and multifactorial clinical condition affecting large population attributed to various factors, including perturbation in oxidative stress the level of essential trace elements. Oxidative insults exert multiple issues related reproductive health, male infertility, decreased sperm motility, DNA damage, an increased susceptibility genetic disorders. Besides chemical toxins food allergens junk items, many drugs can also lead fertility. Olanzapine, general antipsychotic drug, has been reported induce A great deal literature entails that zinc alleviate stress-related complications This study investigates potential protective effects sulphate on olanzapine-induced infertility. In present study, there were four treatment groups (n = 6) Group 1 as control (without any treatment); 2 treated with olanzapine (10 mg/kg) orally daily for six weeks; 3 4 50mg/kg 100 mg/kg respectively pre-exposed (10mg/kg) weeks. After completion treatment, biochemical analysis serum tissue samples demonstrated group had compromised levels antioxidant parameters (SOD, CAT GSH) well elevated (GSSG, MDA NO). However, ZnSO4 corrected all these dose-dependent way 4. Other health indicators, like taurine, enzyme Q10, phosphatidylcholine, ascorbic acid, vitamin E, observed improve supplementation ZnSO4. Intriguingly, fertility (sperm count testosterone) found significantly enhanced abnormalities both combination groups. The histological evaluation testis section agreed analysis. Therefore, strongly advocates Zn ameliorate significant extent.

Language: Английский

Citations

0