Muscarinic Receptors and Alzheimer’s Disease: New Perspectives and Mechanisms

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 6820 - 6835

Published: July 2, 2024

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases on a global scale. Historically, this pathology has been linked to cholinergic transmission, and despite scarcity effective therapies, numerous alternative processes targets have proposed as potential avenues for comprehending complex illness. Nevertheless, fundamental pathophysiological mechanisms underpinning AD remain largely enigmatic, with growing body evidence advocating significance muscarinic receptors in modulating brain's capacity adapt generate new memories. This review summarizes current state art field receptors' involvement AD. A specific key factor was relationship between comorbidity emergence mechanisms.

Language: Английский

PET in neurotherapeutic discovery and development

Neurotherapeutics, Journal Year: 2024, Volume and Issue: unknown, P. e00498 - e00498

Published: Dec. 1, 2024

Language: Английский