Bioactive Formulation and Bulk Allopurinol and Lycopene Estimation by UV Spectroscopy DOI
Soumya Mishra, Ranjit K. Harwansh, Rupa Mazumder

et al.

Drug Metabolism and Bioanalysis Letters, Journal Year: 2024, Volume and Issue: 17(2), P. 56 - 66

Published: Oct. 8, 2024

Background: This study developed a UV spectrophotometric method for quantifying allopurinol and lycopene in both bulk dosage forms, aiming simplicity practicality. Materials Methods: The was validated using methanol lyco-pene phosphate buffer saline at various pH levels (7.4, 6.8, 1.2, 5.5). Validation parameters included linearity, accuracy, precision, limit of quantification (LOQ), detection (LOD) according to ICH standards. Results: demonstrated high sensitivity linearity over concentration range 4-20 μg/ml, adhering Beer's law. LOQ LOD were 2-18 μg/ml 2-6 respectively. Optimal absorbance wavelengths 251 nm 471 allopurinol. Calibration curves showed correlation coefficient (0.9994), indicating strong linear relationship. Conclusion: is effective, interference-free, suitable routine quality control, providing reliable measurements lyco-pene.

Language: Английский

Synthesis, in vivo evaluation, and in silico molecular docking of benzo[h]quinoline derivatives as potential Culex pipiens L. larvicides DOI
Sayed K. Ramadan,

Wael S. I. Abou‐Elmagd,

Eslam M. Hosni

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108090 - 108090

Published: Dec. 27, 2024

Language: Английский

Citations

6

Harnessing nanomaterials for copper-induced cell death DOI

Su-Ran Li,

Shi-Yue Tao,

Qian Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122805 - 122805

Published: Sept. 3, 2024

Language: Английский

Citations

5

The potential of flavonoids in hepatic fibrosis: A comprehensive review DOI
Wenbo Zhu, Jianwei Han,

Liu Hua

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155932 - 155932

Published: Aug. 8, 2024

Language: Английский

Citations

4

Evaluation and identification of Nutritional factors, cytotoxic condition, and protodioscin in Dioscorea alata tuber DOI
Suvathika Gnanaselvan, Sowmya Priya Manoharan,

S. Baskar

et al.

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 178, P. 131 - 138

Published: Jan. 22, 2025

Language: Английский

Citations

0

Capilliposide A relieved dry age-related macular degeneration through ROS/SIRT1/P53 signaling pathway DOI

Fanwei Xia,

Luping Wang,

Ying Ji

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177412 - 177412

Published: Feb. 1, 2025

Language: Английский

Citations

0

Pathological and molecular insights into intravenous leiomyomatosis: an integrative multi-omics study DOI Creative Commons
Sheng Yin,

Peipei Shi,

Jing Han

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 26, 2025

Intravenous leiomyomatosis (IVL) is a histologically well differentiated smooth muscle tumor with aggressive behavior, capable of extending throughout the venous system. Understanding how IVL occurs and develops really important for diagnosing treating it. Unfortunately, because quite rare, there aren't many comprehensive studies available. In our research, we carried out an extensive multi-omics study, gathering tissue samples from cases, uterine fibroid, normal myometrium. The single-cell RNA sequencing analysis revealed notable difference in cell composition between fibroid. Additionally, H&E staining demonstrated more frequent hydropic changes hyalinization tissues, along reduced vascular density compared to both myometrium proteomics eight paired fresh frozen tissue, identified proteins that were differentially expressed, mainly related focal adhesions regulation actin cytoskeleton. most frequently involved chromosomes included deletions 10q22.2, 10q24.32, 13q14, 13q21-31. Correlation analyses highlighted chromosome 10q as cytoband, corresponding regulating Integrated pathological clinical characteristics indicated deletion morphology could serve markers predicting behavior. Our study sheds light on molecular linked IVL, which pave way new treatment approaches.

Language: Английский

Citations

0

Lyotropic liquid crystalline nanoparticles of morin: An approach to improve pharmacokinetics and brain disposition in rats via nose-to-brain pathway DOI
Dhrumi Patel, Sarika Wairkar

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102823 - 102823

Published: April 1, 2025

Language: Английский

Citations

0

Therapeutic Potential of Enzymes, Neurosteroids, and Synthetic Steroids in Neurodegenerative Disorders: A Critical Review DOI
Refik Servi, Ramazan Fazıl Akkoç, Feyza Aksu

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: 251, P. 106766 - 106766

Published: April 25, 2025

Language: Английский

Citations

0

Dual roles of LncRNA RNA143598: a biomarker for rheumatoid arthritis and its implications in cancer DOI
Qiuhua Wu, Xiaoxia Zhang,

Mingfang Qin

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0

18β-Glycyrrhetinic Acid from Glycyrrhiza Uralensis Protects Colonic Epithelium in Ulcerative Colitis by activating Wnt/β-catenin pathway to restore Tight Junction DOI
Xi Peng,

Rao Zhong,

Shi Dong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 143, P. 156830 - 156830

Published: May 4, 2025

Language: Английский

Citations

0