Pharmacological Research, Journal Year: 2019, Volume and Issue: 152, P. 104616 - 104616
Published: Dec. 26, 2019
Language: Английский
Frontiers in Pharmacology, Journal Year: 2016, Volume and Issue: 7
Published: June 29, 2016
Epimedium (family Berberidaceae), commonly known as Horny Goat Weed or Yin Yang Huo, is used a tonic, aphrodisiac, anti-rheumatic and anti-cancer agent in traditional herbal formulations Asian countries such China, Japan Korea. The major bioactive compounds present within this plant include icariin, icaritin icariside II. Although it best for its aphrodisiac properties, scientific pharmacological studies suggest possesses broad therapeutic capabilities, especially enhancing reproductive function osteoprotective, neuroprotective, cardioprotective, anti-inflammatory immunoprotective effects. In recent years, there has been great interest investigation of the purported properties icariin derivatives. Data from vitro vivo suggests these demonstrate activity against wide range cancer cells which occurs through various mechanisms apoptosis, cell cycle modulation, anti-angiogenesis, anti-metastasis immunomodulation. Of note, they are efficient at targeting stem drug-resistant cells. These highly desirable to be emulated development novel drugs combatting emergence drug resistance overcoming limited efficacy current standard treatment. This review aims summarize derivatives with reference published literature. currently utilized applications treatment explored existing patents. Based on data compiled, shown tremendous potential new drugs.
Language: Английский
Citations
133
Journal of Cellular and Molecular Medicine, Journal Year: 2015, Volume and Issue: 20(3), P. 389 - 402
Published: Dec. 9, 2015
Abstract Cancer is a multi‐faceted disease comprised of combination genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis cell growth death. Rational developments highly selective drugs specifically block only one pathways have been associated with limited therapeutic success. Multi‐targeted prevention cancer has emerged as new paradigm for effective anti‐cancer treatment. Platycodin D, triterpenoid saponin, major active components roots Platycodon grandiflorum possesses multiple biological pharmacological properties including, anti‐nociceptive, anti‐atherosclerosis, antiviral, anti‐inflammatory, anti‐obesity, immunoregulatory, hepatoprotective anti‐tumour activities. Recently, activity platycodin D extensively studied. The purpose this review was to give our perspectives on current status discuss its molecular mechanisms may help further design conduct pre‐clinical clinical trials develop it successfully into potential lead drug oncological therapy. shown fight by inducing apoptosis, cycle arrest, autophagy inhibiting angiogenesis, invasion metastasis targeting are frequently deregulated in cancers suggesting that multi‐target rather than single effect play an important role developing drug.
Language: Английский
Citations
124
Bioscience Reports, Journal Year: 2019, Volume and Issue: 39(8)
Published: July 31, 2019
Abstract Cancer cells have the unique ability to overcome natural defense mechanisms, undergo unchecked proliferation and evade apoptosis. While chemotherapeutic drugs address this, they are plagued by a long list of side effects poor success rate. This has spurred researchers identify safer bioactive compounds that possess chemopreventive therapeutic properties. A wide range experimental as well epidemiological data encourage use dietary agents impede or delay different stages cancer. In present study, we examined anti-ancer property ubiquitous phytochemical quercetin using cell viability assay, flow cytometry, nuclear morphology, colony formation, scratch wound DNA fragmentation comet assay. Further, qPCR analysis various genes involved in apoptosis, cycle regulation, metastasis signal transduction pathways was performed. Proteome profiler used quantitate expression several these proteins. We find decreases viability, reduces promotes G2-M arrest, induces damage encourages Quercetin apoptosis via activating both apoptotic with stronger effect extrinsic pathway relying on combined power TRAIL, FASL TNF up-regulation caspases pro-apoptotic genes. could inhibit anti-apoptotic proteins docking studies. blocks PI3K, MAPK WNT pathways. Anticancer observed cell-based assays were corroborated molecular biology studies yielded valuable mechanistic information. appears be promising candidate potential warrants further research.
Language: Английский
Citations
121
Oncotarget, Journal Year: 2017, Volume and Issue: 8(34), P. 57870 - 57881
Published: June 27, 2017
Zhi-Hua Ouyang1,2, Wen-Jun Wang2, Yi-Guo Yan2, Bing Wang1 and Guo-Hua Lv1 1Department of Spine Surgery, The 2nd Xiangya Hospital Central South University, Changsha, China 2Department First Affiliated Hospital, University China, Hengyang, Correspondence to: Lv, email: [email protected] Keywords: IDD, PI3K, Akt, PTEN, mTOR Received: November 07, 2016 Accepted: May 10, 2017 Published: June 27, ABSTRACT Intervertebral disc degeneration (IDD) is thought to be the primary cause low back pain, a severe public health problem worldwide. Current therapy for IDD aims alleviate symptoms does not target underlying pathological alternations within disc. Activation phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against which attributed increase ECM content, prevention cell apoptosis, facilitation proliferation, induction or autophagy, alleviation oxidative damage, adaptation hypoxic microenvironment. In current review, we summarize recent progression on activation negative regulation PI3K/Akt signaling pathway, highlight its impact IDD. Targeting this could become an attractive therapeutic strategy in near future.
Language: Английский
Citations
120
Pharmacological Research, Journal Year: 2018, Volume and Issue: 130, P. 273 - 291
Published: Jan. 4, 2018
Language: Английский
Citations
106
International Journal of Biological Sciences, Journal Year: 2019, Volume and Issue: 15(8), P. 1600 - 1609
Published: Jan. 1, 2019
Natural products, an infinite treasure of bioactive scaffolds, have provided excellent reservoir for the discovery drugs since millennium.These naturally occurring, biologically active and therapeutically effective chemical entities emerged as novel paradigm prevention various diseases.This review aims to give update on sources well pharmacological profile curcumol, a pharmacologically sesquiterpenoid, which is imperative constituent several plants mainly from genus Curcuma.Curcumol has potential fight against cancer, oxidative stress, neurodegeneration, microbial infections, inflammation.Curcumol been documented potent inducer apoptosis in numerous cancer cells via targeting key signaling pathways MAPK/ERK, PI3K/Akt NF-κB are generally deregulated cancers.The reported data reveals multitarget activity curcumol treatment suggesting its importance anticancer drug future.It speculated that may provide opportunity cure but further investigations mechanism action preclinical trials still mandatory validate this natural killer therapies.
Language: Английский
Citations
104
Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)
Published: July 18, 2017
Alantolactone (ALT), a sesquiterpene lactone component of Inula helenium, has been reported to exert anticancer activity in various cancers. However, the cellular targets and underlying mechanism ALT cancers including lung cancer not fully defined. In present study, we found that effectively inhibits proliferation triggers oxidative stress mediated-apoptosis A549 adenocarcinoma cells by inducing ER mitochondrial dysfunction. This ALT-mediated apoptosis was inhibited NAC while diamide potentiated it. Moreover, suppressed both constitutive inducible STAT3 activation, its translocation into nucleus decreased DNA binding activity. Further mechanistic study revealed abrogated activation promoting glutathionylation. ROS scavenger reverted glutathionylation inhibition phosphorylation. Finally, enhanced chemosensitivity doxorubicin reversed resistance A549/DR inhibiting P-glycoprotein expression increasing intracellular accumulation doxorubicin. Suppression targeting metabolism with thus discloses previously unrecognized biological ALT. Taken together; induces stress-dependent apoptosis, augments toxicity cells. These findings provide an in-depth insight molecular treatment cancer.
Language: Английский
Citations
91
Cancers, Journal Year: 2021, Volume and Issue: 13(14), P. 3427 - 3427
Published: July 8, 2021
Breast cancer is the most frequently diagnosed and leading cause of death among women worldwide. Despite overall successes in breast therapy, hormone-independent HER2 negative cancer, also known as triple (TNBC), lacking estrogens progesterone receptors with an excessive expression human epidermal growth factor receptor 2 (HER2), along positive subtype, still remain major challenges treatment. Due to their poor prognoses, aggressive phenotype, highly metastasis features, new alternative therapies have become urgent clinical need. One noteworthy phytochemicals, curcumin, has attracted enormous attention a promising drug candidate prevention treatment due its multi-targeting effect. Curcumin interrupts stages tumorigenesis including cell proliferation, survival, angiogenesis, through modulation multiple signaling pathways. The current review highlighted anticancer activity curcumin via focusing on impact key pathways PI3K/Akt/mTOR pathway, JAK/STAT MAPK NF-ĸB p53 Wnt/β-catenin, well apoptotic cycle Besides, therapeutic implications trials are here presented.
Language: Английский
Citations
91
Oncogenesis, Journal Year: 2017, Volume and Issue: 6(2), P. e298 - e298
Published: Feb. 20, 2017
Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number oncogenic signaling pathways various malignancies. However, little is known about its role gastric cancer prognosis genotoxic resistance. Here we found that AURKA was highly overexpressed inversely correlated with disease prognosis. Overexpression exacerbated drug resistance through upregulating expression anti-apoptotic protein Survivin. Conversely, demonstrated depletion caused decrease Survivin levels by increasing ubiquitylation degradation. Mass spectrometric analysis revealed upon depletion, bound to FBXL7 E3 ubiquitin ligase, which induced ubiquitin-proteasome degradation In addition, showed regulated both at transcription translation. Moreover, proteomic nuclear AURKA-interacting proteins identified Forkhead box P1 (FOXP1). We next required for negatively FOXP1-mediated expression. The physiological relevance FOXP1-FBXL7 axis further underscored significant positive correlations between patient samples. or inhibition-induced apoptotic death could be reversed ectopic overexpression, supporting enhance agreement, inhibition synergistically enhanced cytotoxic effect DNA-damaging agents cells suppressing Taken together, our data suggest restricts promote hence AURKA-Survivin can targeted efficacy cancer.
Language: Английский
Citations
90
Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10
Published: July 12, 2019
Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis process programmed cell death it plays vital role in human development tissue homeostasis. Mounting evidence indicates that apoptosis closely related to the survival cancer has emerged as key target for discovery novel anticancer drugs. Various studies indicate targeting apoptotic signaling pathway by drugs an important mechanism therapy. Therefore, numerous agents have been discovered developed from traditional Chinese medicines (TCMs) cellular cells shown clinically beneficial effects This review aims provide comprehensive discussion role, pharmacology, biology possible mechanism(s) number TCMs their derivatives mainly pathway. It may clinical implication
Language: Английский
Citations
79