Nutraceuticals and Cancer: Potential for Natural Polyphenols

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3834 - 3834

Published: Oct. 27, 2021

Cancer is one of the leading causes death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake toxins have been found contribute development and progression cancer disease states. Early detection proper treatment enhance chances survival healing, but side effects anticancer drugs still produce detrimental responses that counteract benefits in terms hospitalization survival. Recently, several natural bioactive compounds were possess properties, capable killing transformed cancerous cells without being toxic their normal counterparts. This effect occurs when products are conventional treatments, thereby suggesting nutraceutical supplementation may successful therapy. review aims discuss current literature on four extracts mostly characterized by a specific polyphenolic profile. activities reported support treatment: (1) inhibition cell proliferation, (2) antioxidant activity, (3) anti-inflammatory activity. On other hand, owing attenuation therapies, antioxidants improving compliance patients undergoing treatment. Thus, supplementation, along drug treatment, be considered for better cancer. It should noted, however, data from studies plant preparations discussed, it appropriate ensure experiments conducted accordance accepted pharmacological research practices so as not disclose information only partially correct.

Language: Английский

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Curcumin as an Enhancer of Therapeutic Efficiency of Chemotherapy Drugs in Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2144 - 2144

Published: Feb. 15, 2022

Female breast cancer is the world’s most prevalent in 2020. Chemotherapy still remains a backbone therapy and crucial advanced metastatic treatment. The clinical efficiency of chemotherapy regimens limited due to tumor heterogeneity, chemoresistance, side effects. Chemotherapeutic drug combinations with natural products hold great promise for enhancing their anticancer efficacy. Curcumin an ideal chemopreventive agent owning its multitargeting function on various regulatory molecules, key signaling pathways, pharmacological safety. This review aimed elucidate potential role curcumin efficacy doxorubicin, paclitaxel, 5-fluorouracil, cisplatin via combinational therapy. Additionally, molecular mechanisms underlying chemosensitizing activity these have been addressed. Overall, based promising therapeutic combination conventional drugs, considerable value develop as adjunct current drugs treat cancer. Furthermore, this topic may provide frameworks future research direction curcumin–chemotherapy studies benefit development novel strategy maximize while minimizing effects

Language: Английский

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Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 672 - 672

Published: April 12, 2024

Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite favorable characteristics, curcumin encounters various formulation challenges stability issues can be effectively addressed through application nanotechnology. Nano-based techniques specifically focused on enhancing solubility, bioavailability, therapeutic efficacy while mitigating toxicity, have been explored curcumin. This review systematically presents information improvement curcumin’s beneficial properties when incorporated, either individually or conjunction with other drugs, into nanosystems such as liposomes, nanoemulsions, polymeric micelles, dendrimers, nanoparticles, solid-lipid nanostructured lipid carriers. Additionally, examines ongoing clinical trials recently granted patents, offering a thorough overview dynamic landscape delivery. Researchers are currently exploring nanocarriers crucial features surface modification, substantial loading capacity, biodegradability, compatibility, autonomous targeting specificity selectivity. Nevertheless, utilization delivery still initial phases, regulatory approval pending persistent safety concerns surrounding their use.

Language: Английский

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Development and Evaluation of SA/PVP/γ-Al₂O₃ Nanocarriers for Targeted Delivery of Curcumin in Colon Cancer Therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106632 - 106632

Published: Jan. 1, 2025

Language: Английский

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Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 15, 2021

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role cancer progression suitable therapeutic target. The use small molecule inhibitors however, has been crippled by the emergence resistance, highlighting need for pleiotropic anti-cancer agent can replace or be used combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive mainly due potent effects, extensive range targets minimal toxicity. Out numerous documented curcumin, RTKs appear one main nodes curcumin-mediated inhibition. Many studies have found curcumin influences activation their downstream signaling pathways resulting increased decreased proliferation migration both vitro vivo. This review focused on how exhibits effects through inhibition MAPK, PI3K/Akt, JAK/STAT, NF-κB pathways. Combination were also analysed emphasis common molecular targets.

Language: Английский

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Curcumin and Plumbagin Synergistically Target the PI3K/Akt/mTOR Pathway: A Prospective Role in Cancer Treatment

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6651 - 6651

Published: April 2, 2023

Cancer development is associated with the deregulation of various cell signaling pathways brought on by certain genetic and epigenetic alterations. Therefore, novel therapeutic strategies have been developed to target those pathways. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian rapamycin (mTOR) (PI3K/Akt/mTOR) pathway one major deregulated in types cancer. Several anticancer drug candidates are currently being investigated preclinical and/or clinical studies this pathway. Natural bioactive compounds provide an excellent source for development. Curcumin plumbagin two potential that shown PI3K/Akt/mTOR individually. However, their combinatorial effect cancer cells still unknown. This study aims investigate synergistic these employing a sequential molecular docking dynamics (MD) analysis. An increase binding affinity decrease inhibition constant observed when curcumin were subjected against key proteins PI3K, Akt, mTOR. MD simulations mechanics combined generalized Born surface area (MM-GBSA) analyses validated proteins' more stable conformation interacting combination. indicates role possible dose advantage used findings pave way further investigation vitro vivo models.

Language: Английский

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Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 30 - 30

Published: Jan. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Language: Английский

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Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications

Cancer Pathogenesis and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects

Pharmaceuticals, Journal Year: 2021, Volume and Issue: 14(11), P. 1068 - 1068

Published: Oct. 22, 2021

Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules molecular mechanisms involved against Her-2/neu-positive breast salivary cancer cell lines. We found that both curcumin were efficient in reducing survival they differently affected autophagy, ROS activation PI3K/AKT/mTOR pathway. Moreover, combination exerted a stronger effect correlation with induction ER stress upregulation pro-death UPR molecule CHOP. This also correlated pro-survival autophagy by its inhibition resveratrol. conclusion, study unveils new underlying resveratrol, their combination, which can help to design therapeutic strategies based on use polyphenols.

Language: Английский

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Antitumor Properties of Curcumin in Breast Cancer Based on Preclinical Studies: A Systematic Review

Cancers, Journal Year: 2022, Volume and Issue: 14(9), P. 2165 - 2165

Published: April 26, 2022

Breast cancer is one of the most common neoplasms among women. Anticancer strategies using natural formulations and phytotherapies are promising antitumor treatment alternatives. This review assesses effects curcumin on breast reported in preclinical vitro vivo animal models. We used five databases to search for studies published up May 2021. The assessments included proliferation, viability, apoptosis cell lineages tumor volume. In total, 60 articles met inclusion criteria. Curcumin administered at different concentrations via routes administration inhibited decreased induced human cells. Nanoparticle orally, implant, intraperitoneally reduced volume murine mammary cells vivo. Moreover, nanoformulations exert positive growth inhibition models cancer. Further randomized clinical trials warranted assess efficacy safety use.

Language: Английский

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