Clinical and Translational Medicine,
Journal Year:
2023,
Volume and Issue:
13(10)
Published: Oct. 1, 2023
Abstract
Background
To
date,
standardizing
clinical
predictive
biomarkers
for
assessing
the
response
to
immunotherapy
remains
challenging
due
variations
in
personal
genetic
signatures,
tumour
microenvironment
complexities
and
epigenetic
onco‐mechanisms.
Main
Body
Early
monitoring
of
key
non‐coding
RNA
(ncRNA)
may
help
predicting
efficacy
cancer
come
up
with
standard
ncRNA
biomarkers.
For
instance,
reduced
miR‐125b‐5p
level
plasma
non‐small
cell
lung
patients
treated
anti‐PD‐1
predicts
a
positive
outcome.
The
miR‐153
colorectal
chimeric
antigen
receptor
T
lymphocyte
(CAR‐T)
therapy
indicate
activation
T‐cell
killing
activity.
miR‐148a‐3p
miR‐375
levels
forecast
favourable
responses
CAR‐T‐cell
B‐cell
acute
lymphoblastic
leukaemia.
In
GPC3
peptide
vaccine,
serum
miR‐1228‐5p,
miR‐193a‐5p
miR‐375‐3p
were
reported
as
good
improved
overall
survival.
Therefore,
there
is
critical
need
further
studies
elaborate
on
that
have
potential
predict
early
immunotherapy.
Conclusions
This
review
summarises
important
different
immunotherapeutic
modalities
including
monoclonal
antibodies,
small
molecule
inhibitors,
vaccines
CAR‐T
cells.
addition,
concise
discussion
forthcoming
perspectives
provided,
outlining
technical
approaches
optimal
utilisation
immune‐modulatory
tools
therapeutic
targets.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(4), P. 663 - 663
Published: March 30, 2022
Among
gynaecologic
malignancies,
ovarian
cancer
is
one
of
the
most
dangerous,
with
a
high
fatality
rate
and
relapse
due
to
occurrence
chemoresistance.
Many
researchers
demonstrated
that
oxidative
stress
involved
in
tumour
occurrence,
growth
development.
Nuclear
factor
erythroid
2-related
2
(NRF2)
an
important
transcription
factor,
playing
role
protecting
against
damage.
Increased
levels
Reactive
Oxygen
Species
(ROS)
activate
NRF2
signalling,
inducing
expression
antioxidant
enzymes,
such
as
haem
oxygenase
(HO-1),
catalase
(CAT),
glutathione
peroxidase
(GPx)
superoxide
dismutase
(SOD),
protect
cells
stress.
However,
activation
responsible
for
development
chemoresistance,
inactivating
drug-mediated
normally
leads
cells’
death.
In
this
review,
we
report
evidence
from
literature
describing
effect
on
cancer,
focus
its
function
drug
resistance,
natural
synthetic
modulators
protective
normal
preservation.
Cell Reports Medicine,
Journal Year:
2024,
Volume and Issue:
5(4), P. 101488 - 101488
Published: April 1, 2024
Most
recurrences
of
lung
cancer
(LC)
occur
within
3
years
after
surgery,
but
the
underlying
mechanism
remains
unclear.
Here,
we
collect
LC
tissues
with
shorter
(<3
years,
recurrence
group)
and
longer
(>3
non-recurrence
recurrence-free
survival.
By
using
16S
sequencing,
find
that
intratumor
microbiome
diversity
is
lower
in
group
butyrate-producing
bacteria
are
enriched
group.
The
signature
circulating
DNA
can
accurately
predict
recurrence.
We
prove
injection
Roseburia
promote
subcutaneous
tumor
growth.
Mechanistically,
bacteria-derived
butyrate
promotes
metastasis
by
increasing
expression
H19
cells
through
inhibiting
HDAC2
H3K27
acetylation
at
promoter
inducing
M2
macrophage
polarization.
Depletion
macrophages
partially
abolishes
metastasis-promoting
effect
butyrate.
Our
results
provide
evidence
for
cross-talk
between
suggest
potential
prognostic
therapeutic
value
microbiome.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 13, 2023
Abstract
Cancer
is
a
complex
disease
with
many
contributing
factors,
and
researchers
have
gained
extensive
knowledge
that
has
helped
them
understand
the
diverse
varied
nature
of
cancer.
The
altered
patterns
DNA
methylation
found
in
numerous
types
cancer
imply
they
may
play
part
disease’s
progression.
human
condition
involves
dysregulation
methyltransferase
3
beta
(DNMT3B)
gene,
prominent
de
novo
methyltransferase,
its
abnormal
behavior
serves
as
an
indicator
for
tumor
prognosis
staging.
expression
non-coding
RNAs
(ncRNAs),
which
include
microRNAs
(miRNA),
long
(lncRNAs),
circular
(circRNAs),
critical
controlling
targeted
gene
protein
translation
their
correlates
onset
tumors.
NcRNAs
factor
influences
modulation
several
cellular
characteristics
cancerous
cells.
These
but
are
not
limited
to,
drug
responsiveness,
angiogenesis,
metastasis,
apoptosis,
proliferation,
properties
stem
cell.
reciprocal
regulation
ncRNAs
DNMT3B
can
act
synergy
to
influence
destiny
Thus,
avenue
advancing
prevention
treatment
inquiry
into
interplay
between
ncRNAs.
In
this
review,
we
present
comprehensive
overview
ncRNAs/DNMT3B
axis
pathogenesis.
This
brings
about
valuable
insights
intricate
mechanisms
tumorigenesis
provides
foundation
developing
effective
therapeutic
interventions.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Feb. 14, 2024
Long
noncoding
RNAs
(lncRNAs)
are
a
group
of
with
transcript
lengths
>200
nucleotides.
Mounting
evidence
suggests
that
lncRNAs
closely
associated
tumorigenesis.
LncRNA
H19
(H19)
was
the
first
lncRNA
to
function
as
an
oncogene
in
many
malignant
tumors.
Apart
from
established
role
promoting
cell
growth,
proliferation,
invasion,
migration,
epithelial-mesenchymal
transition
(EMT),
and
metastasis,
it
has
been
recently
discovered
also
inhibits
programmed
death
(PCD)
cancer
cells.
In
this
review,
we
summarize
mechanisms
by
which
regulates
PCD
cells
through
various
signaling
pathways,
molecular
mechanisms,
epigenetic
modifications.
Wnt/β-catenin
pathway
PI3K-Akt-mTOR
pathway.
It
acts
competitive
endogenous
RNA
(ceRNA)
regulation.
The
interaction
between
RNA-binding
proteins
(RBP)
apoptosis
cancer.
Moreover,
modifications,
including
DNA
methylation
histone
involved
H19-associated
conclusion,
via
chemoresistance,
highlighting
promising
research
significance
therapeutic
target.
We
hope
our
study
will
contribute
broader
understanding
development
treatment.
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(2)
Published: Jan. 10, 2024
Abstract
Recently,
extracellular
vesicles
(EVs)
have
been
emphasized
in
regulating
the
hypoxic
tumor
microenvironment
of
breast
cancer
(BC),
where
tumor‐associated
fibroblasts
(TAFs)
play
a
significant
role.
In
this
study,
we
describe
possible
molecular
mechanisms
behind
pro‐tumoral
effects
EVs,
secreted
by
hypoxia
(HP)‐induced
TAFs,
on
BC
cell
growth,
metastasis,
and
chemoresistance.
These
are
based
long
noncoding
RNA
H19
(H19)
identified
microarray
analysis.
We
employed
an
silico
approach
to
identify
differentially
expressed
lncRNAs
that
were
associated
with
BC.
Subsequently,
explored
downstream
regulatory
mechanisms.
isolated
EVs
from
TAFs
exposed
HP,
these
denoted
as
HP‐TAF‐EVs
henceforth.
MTT,
transwell,
flow
cytometry,
TUNEL
assays
performed
assess
malignant
phenotypes
cells.
A
paclitaxel
(TAX)‐resistant
line
was
constructed,
xenograft
lung
metastasis
models
established
nude
mice
for
vivo
verification.
Our
observation
revealed
lncRNA
significantly
overexpressed,
whereas
miR‐497
notably
downregulated
HP
induced
activation
stimulated
secretion
EVs.
Coculture
cells
led
increase
TAX
resistance
latter.
upregulated
methylation
delivering
H19,
which
recruited
DNMT1,
thus
lowering
expression
miR‐497.
addition,
H19‐containing
hindered
expression,
enhancing
tumorigenesis
vivo.
study
presents
evidence
contribution
reduction
through
recruitment
turn
promotes
chemoresistance
BMC Cancer,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 2, 2024
Long
non-coding
RNA
(lncRNA)
H19
has
gained
significant
recognition
as
a
pivotal
contributor
to
the
initiation
and
advancement
of
gynecologic
cancers,
encompassing
ovarian,
endometrial,
cervical,
breast
cancers.
exhibits
complex
array
mechanisms,
demonstrating
dualistic
effects
on
tumorigenesis
it
can
function
both
an
oncogene
tumor
suppressor,
contingent
upon
specific
context
type
cancer
being
investigated.
In
ovarian
cancer,
promotes
growth,
metastasis,
chemoresistance
through
modulation
key
signaling
pathways
interaction
with
microRNAs.
Conversely,
in
endometrial
acts
suppressor
by
inhibiting
proliferation,
inducing
apoptosis,
regulating
epithelial-mesenchymal
transition.
Additionally,
been
implicated
cervical
where
influences
cell
invasion,
immune
evasion.
Moreover,
potential
diagnostic
prognostic
biomarker
for
its
expression
levels
correlating
clinical
parameters
patient
outcomes.
Understanding
functional
roles
cancers
is
crucial
development
targeted
therapeutic
strategies
personalized
treatment
approaches.
Further
investigation
into
intricate
molecular
mechanisms
underlying
H19's
involvement
malignancies
warranted
fully
unravel
implications.
This
review
aims
elucidate
various
malignancies.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Nov. 5, 2021
Extracellular
vesicles
(EVs)
exert
their
biological
functions
by
delivering
proteins,
metabolites,
and
nucleic
acids
to
recipient
cells.
EVs
play
important
roles
in
cancer
development.
The
anti-tumor
effect
of
is
cargos
carrying
affect
cell-to-cell
communication.
characteristics
communication
can
potentially
be
applied
for
the
therapy
cancers,
such
as
gastric
cancer.
In
addition,
used
an
effective
deliver
ncRNAs,
peptides,
drugs,
target
tumor
tissues.
have
ability
regulate
cell
apoptosis,
autophagy,
proliferation,
migration
ncRNA
peptides
that
were
engaged
with
associated
signaling
pathways
This
review
focuses
on
composition,
cargo,
function,
mechanism,
application
cancers.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2411 - 2411
Published: Aug. 28, 2023
This
comprehensive
review
elucidates
the
intricate
roles
of
long
non-coding
RNAs
(lncRNAs)
within
colorectal
cancer
(CRC)
microenvironment,
intersecting
domains
immunity,
intercellular
communication,
and
therapeutic
potential.
lncRNAs,
which
are
significantly
involved
in
pathogenesis
CRC,
immune
evasion,
treatment
response
to
have
crucial
implications
inflammation
serve
as
promising
candidates
for
novel
strategies
biomarkers.
scrutinizes
interaction
lncRNAs
with
Consensus
Molecular
Subtypes
(CMSs)
their
complex
interplay
tumor
stroma
affecting
immunity
inflammation,
conveyance
via
extracellular
vesicles,
particularly
exosomes.
Furthermore,
we
delve
into
relationship
between
other
RNAs,
including
microRNAs
circular
mediating
cell-to-cell
communication
CRC
microenvironment.
Lastly,
propose
potential
manipulate
enhance
anti-tumor
thereby
underlining
significance
devising
innovative
interventions
CRC.
