Senescence-associated secretory phenotype (SASP) and uterine fibroids: Association with PD-L1 activation and collagen deposition

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102314 - 102314

Published: April 24, 2024

Language: Английский

---

Intersecting Pathways: The Role of Hybrid E/M Cells and Circulating Tumor Cells in Cancer Metastasis and Drug Resistance

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 76, P. 101119 - 101119

Published: July 14, 2024

Language: Английский

---

Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: June 16, 2023

Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% all cases. Multiple distant metastases are major cause mortality in cancer. In this study, single-cell sequencing datasets LUAD were utilized to depict transcriptome characteristic based on bioinformatic method. Firstly, landscape heterogeneous types was analyzed memory T cells, NK helper cells revealed be immune tumor, normal, metastasis tissue, respectively. Then, marker genes calculated 709 identified play a vital role microenvironment LUAD. While macrophages reported act as one LUAD, enrichment analysis macrophage important activation neutrophils. Next, results cell-cell communication suggested that pericytes interact with broad via MDK-NCL pathways samples, MIF-(CD74+CXCR4) MIF-(CD74+CC44) interaction especially occurred between different tumor normal samples. Finally, bulk RNA-seq integrated validate prognosis effect gene maker M2 macrophage, CCL20, showed related prognosis. Besides, ZNF90 (Helper cells), FKBP4 (memory T, Cytotoxic B CD79A (B TPI1 (pericyte), HOPX (epithelial pericytes) also pivotal pathology helping researchers understand molecular insight

Language: Английский

---

SFXN1-mediated immune cell infiltration and tumorigenesis in lung adenocarcinoma: A potential therapeutic target

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111918 - 111918

Published: March 26, 2024

Language: Английский

---

Plasma Olink Proteomics Identifies CCL20 as a Novel Predictive and Diagnostic Inflammatory Marker for Preeclampsia

Journal of Proteome Research, Journal Year: 2022, Volume and Issue: 21(12), P. 2998 - 3006

Published: Oct. 27, 2022

Inflammation is generally thought to be involved in the occurrence and development of preeclampsia (PE), but its specific effect on PE remains unclear. In present study, expression levels 92 inflammation-related proteins were measured late pregnancy maternal plasma from patients with (n = 15) normal pregnant controls using Olink inflammation panel based highly sensitive proximity extension assay technology. A total 28 markers differed between control groups. Among them, fibroblast growth factor 21 (FGF-21) cysteine-cysteine motif chemokine ligand 20 (CCL20) had largest fold changes. We further validated CCL20 (43 44 controls) early (37 37 enzyme-linked immunosorbent (ELISA). To best our knowledge, for first time, was found upregulated an area under curve (AUC) 0.753 0.668, respectively. conclusion, increased most inflammatory markers, might a novel potential predictive diagnostic biomarker PE.

Language: Английский

---

CCL20 in the tumor microenvironment: implications for cancer progression and therapeutic approaches

Clinical & Translational Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Increasing knowledge of the immunosuppressive tumor microenvironment in cancer-related processes has led to developing novel immune-based therapies that have changed cancer treatment paradigm. In microenvironment, plethora soluble factors secreted by cells interacts with immune and non-immune components deliver signals necessary for progression. Accordingly, targeting tumor-derived inducing this become an appealing therapeutic potential advancing treatment. CCL20, a chemokine best known induce leucocyte migration response pathological inflammatory conditions, been implicated proliferation, angiogenesis, metastasis, immunosuppression, resistance. Notably, CCL20 its receptor CCR6 are important interactions. This review discusses interaction between CCL20–CCR6 axis how these interactions promote Also, outline studies utilizing combination other standard treatments shed.

Language: Английский

---

Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2275 - 2275

Published: March 4, 2025

Food intake is an essential contributor to both health and disease. Nutrients contribute a beneficial metabolic equilibrium at the cellular level, preventing or delaying disease onset. Dietary contributes obesity, obesity supports further cancer metastasis. Metastasis, multifactorial multistep process, supported by systemic inflammation of obesity. Spreading cells requires presence plethora recruiter regulator molecules. Molecules such as chemokines are provided high levels obesity-associated fat depots. Chemokine up-regulation in adipose tissue obese individuals has been associated with different types cancers breast, prostate, colon, liver, stomach. Chemokines support all metastasis steps from invasion/migration intravasation, circulation, extravasation, ending colonization. The pool supporting these processes includes CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL18, CCL19, CCL20, CXCL1, CXCL5, CXCL 8, CXCL10, CXCL12. Keeping under control can be reducing pro-inflammatory risk poor outcome. help, support, boost treatment effects jeopardize treatment. Constituents anti-inflammatory anti-obesity properties polyphenols, organosulfur components, fatty acids, curcumin, vitamin E have proven effect lowering its contribution

Language: Английский

---

Development and Validation of a Basement Membrane Inflammatory Response Gene Signature in Lung Adenocarcinoma

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Inflammatory cell infiltration within the tumor microenvironment compromises basement membrane’ integrity, contributing to chemotherapy resistance and distant metastasis. This study investigates interplay between inflammatory responses membrane-related genes (BMIRGs) in lung adenocarcinoma (LUAD). With datasets from TCGA GEO databases, BMIRG risk-score model was developed based on univariate Cox regression a LASSO-Cox model. Nine were identified as comprising signature. Using this signature, we predictive models, including risk scores nomogram models. Stratifying patients into high-and low-risk groups revealed more favorable prognosis latter group. Additionally, signature exhibited correlations with drug sensitivity, immunotherapy response, of multiple immune cells factors microenvironment. The role one CCL20, further validated using intro experiments tissue samples Chinese LUAD. Functional that inhibiting CCL20 attenuated migration both A549 H1299 cells. Immunohistochemistry (IHC) Western blot (WB) analyses demonstrated protein levels significantly elevated LUAD tissues compared adjacent non-tumor also associated TNM stage. High expression linked shorter overall survival. In conclusion, is robust predictor survival offers valuable clinical tool for management. Moreover, emerges potential diagnostic therapeutic target, given its high association poorer prognosis.

Language: Английский

---

CCL20-CCR6 signaling in tumor microenvironment: Functional roles, mechanisms, and immunotherapy targeting

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189341 - 189341

Published: May 1, 2025

Language: Английский

---

Tertiary lymphoid structure patterns aid in identification of tumor microenvironment infiltration and selection of therapeutic agents in bladder cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 7, 2022

Background Tertiary lymphoid structures (TLSs) are emerging as a potential predictor of prognosis and response to immunotherapy in some solid tumors. However, the comprehensive role TLSs bladder cancer remains unclear. Methods Eighteen (BCa) datasets were downloaded from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), ArratyExpress IMvigor210. Based on 39 validated TLS signature genes (TSGs), we evaluated patterns all patients, correlated with tumor microenvironment (TME) cell-infiltrating characteristics. cox regression model principal component analysis (PCA) algorithms used construct score, which helps quantify pattern individuals. Results landscape TSGs BCa was assessed first. Five distinct four gene clusters determined. cluster C2 A thought be characterized by mature showed better higher immune cells infiltration than other clusters. score discovered tightly level cells, could predict maturation status extent. We found an excellent for patients independent mutation burden (TMB), low related high score. Besides, checkpoint blockade (ICB) commonly chemotherapy drugs. Conclusions Our work demonstrated characteristics BCa. By using evaluate Better understanding usage help instruct clinical strategy precision medicine

Language: Английский

---