ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders

Clinica Chimica Acta, Journal Year: 2023, Volume and Issue: 548, P. 117487 - 117487

Published: July 11, 2023

Language: Английский

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Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114993 - 114993

Published: June 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Language: Английский

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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 101(5), P. 501 - 526

Published: April 4, 2023

Language: Английский

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"When," "Where," and "How" of SARS-CoV-2 Infection Affects the Human Cardiovascular System: A Narrative Review

Balkan Medical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 7 - 22

Published: Jan. 3, 2024

Heartfailure, ischemic myocardial injuries, microvascular disease, Kounis syndrome, prolonged COVID, fibrosis, myocarditis, new-onset hypertension, pericarditis, postural orthostatic tachycardia pulmonary stroke, Takotsubo venous thromboembolism, and thrombocytopenia.In this narrative review, we describe elucidate when, where, how COVID-19 affects the human cardiovascular system in various parts of body that are vulnerable every patient category, including children athletes.

Language: Английский

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Bronchoalveolar lavage single-cell transcriptomics reveals immune dysregulations driving COVID-19 severity

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0309880 - e0309880

Published: Feb. 10, 2025

The continuous threats posed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, including emergence of potentially more infectious and deadly variants, necessitate ongoing studies to uncover novel detailed mechanisms driving disease severity. Using single-cell transcriptomics, we conducted a secondary data analysis bronchoalveolar lavage fluid (BALF) from COVID-19 patients varying severities healthy controls comprehensively examine immune responses. We observed significant cell alterations correlating with In severe cases, macrophages showed upregulation pro-inflammatory genes TNFα IL1β, contributing inflammation tissue damage. Neutrophils exhibited increased activation, marked S100A8, CXCL8, IL1β expression, extended viability reduced phagocytosis. Genes such as MCL1 HIF1α supported viability, while MSR1 MRC1 indicated Enhanced formation neutrophil extracellular traps (NETs) clearance, NET-associated markers, were linked thrombo-inflammation organ Both neutrophils in cases impaired efferocytosis, decreased expression TREM2 downregulation FCGR3B neutrophils, leading accumulation apoptotic cells exacerbating inflammation. characterized M1 high milder had M2 elevated PPARγ. Dendritic (DCs) proportions attenuated MHC class I (HLA-A, HLA-B, HLA-C) co-stimulatory molecules (CD80, CD86), alongside cytochrome c indicating antigen presentation enhanced apoptosis. NK T demonstrated altered receptor gene activation markers IFNγ ISG15, suggesting paradoxical state exhaustion. This highlights critical role dysregulated neutrophil, macrophage, dendritic cell, NK, responses identifying potential therapeutic targets providing insights into disease.

Language: Английский

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α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4188 - 4188

Published: Feb. 20, 2023

α1-Adrenergic receptors (ARs) are members of the G-Protein Coupled Receptor superfamily and with other related (β α2), they involved in regulating sympathetic nervous system through binding activation by norepinephrine epinephrine. Traditionally, α1-AR antagonists were first used as anti-hypertensives, increases vasoconstriction, but not a first-line use at present. The current usage urinary flow benign prostatic hyperplasia. agonists septic shock, increased blood pressure response limits for conditions. However, advent genetic-based animal models subtypes, drug design highly selective ligands, scientists have discovered potentially newer uses both α1-AR. In this review, we highlight treatment potential α1A-AR (heart failure, ischemia, Alzheimer’s disease) non-selective (COVID-19/SARS, Parkinson’s disease, posttraumatic stress disorder). While studies reviewed here still preclinical cell lines rodent disease or undergone initial clinical trials, therapeutics discussed should be non-approved

Language: Английский

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A narrative review on lung injury: mechanisms, biomarkers, and monitoring

Critical Care, Journal Year: 2024, Volume and Issue: 28(1)

Published: Oct. 31, 2024

Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of various respiratory diseases. Effective monitoring lung crucial for optimal management improved outcomes patients This review describes acute chronic diseases characterized by significant current clinical tools assessing health. Furthermore, we summarized mechanisms cell death observed in these highlighted recently identified biomarkers plasma indicative to specific types scaffold structure lung. Last, propose an artificial intelligence-driven model assess disease predict mortality prognosis, aiming achieve precision personalized medicine.

Language: Английский

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The Immunomodulatory Role of Cell-Free Approaches in SARS-CoV-2-Induced Cytokine Storm—A Powerful Therapeutic Tool for COVID-19 Patients

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1736 - 1736

Published: June 16, 2023

Currently, there is still no effective and definitive cure for the coronavirus disease 2019 (COVID-19) caused by infection of novel highly contagious severe acute respiratory syndrome virus (SARS-CoV-2), whose sudden outbreak was recorded first time in China late December 2019. Soon after, COVID-19 affected not only vast majority China’s population but whole world a global health public crisis as new pandemic. It well known that viral can cause distress (ARDS) and, cases, even be lethal. Behind inflammatory process lies so-called cytokine storm (CS), which activates various cytokines damage numerous organ tissues. Since SARS-CoV-2, research groups have been intensively trying to investigate best treatment options; however, limited outcomes achieved. One most promising strategies represents using either stem cells, such mesenchymal cells (MSCs)/induced pluripotent (iPSCs), or, more recently, cell-free approaches involving conditioned media (CMs) their content, extracellular vesicles (EVs) (e.g., exosomes or miRNAs) derived from cells. As key mediators intracellular communication, carry cocktail different molecules with anti-inflammatory effects immunomodulatory capacity. Our comprehensive review outlines complex responsible CS, summarizes present results cell-free-based pre-clinical clinical studies treatment, discusses future perspectives therapeutic applications.

Language: Английский

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COVID-19 beyond the lungs: Unraveling its vascular impact and cardiovascular complications—mechanisms and therapeutic implications

Science Progress, Journal Year: 2025, Volume and Issue: 108(1)

Published: Jan. 1, 2025

COVID-19, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is primarily a illness but significantly affects the cardiovascular system as well. After entering body through tract, directly and indirectly disrupts vascular system. Vascular endothelial cells (ECs), which express ACE2 TMPRSS2, are targets for viral invasion. However, predominant cause of widespread damage “cytokine storm” induced immune response. This leads to EC activation, inflammation, neutrophil neutrophil–platelet aggregation, causing injury. Additionally, increased expression plasminogen activator inhibitor-1 balance between prothrombotic fibrinolytic processes, while activation renin–angiotensin–aldosterone adds oxidative stress endothelium. In heart, SARS-CoV-2 invades ECs, leading apoptosis pyroptosis, exacerbated inflammation elevated catecholamines. These factors contribute arrhythmias, strokes, myocardial infarction in cases COVID-19. narrative review aims explore mechanisms highlight resulting complications. It also identifies research gaps discusses potential therapeutic strategies mitigate impacts

Language: Английский

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Immunity and Coagulation in COVID-19

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11267 - 11267

Published: Oct. 19, 2024

Discovered in late 2019, the SARS-CoV-2 coronavirus has caused largest pandemic of 21st century, claiming more than seven million lives. In most cases, COVID-19 disease by virus is relatively mild and affects only upper respiratory tract; it often manifests itself with fever, chills, cough, sore throat, but also less-common symptoms. patients do not require hospitalization, fully recover. However, some infection leads to development a severe form COVID-19, which characterized life-threatening complications affecting lungs, other organs systems. particular, various forms thrombotic are common among COVID-19. The mechanisms for remain unclear. Accumulated data indicate that pathogenesis based on disruptions functioning innate immune key role primary response viral assigned two These pattern recognition receptors, primarily members toll-like receptor (TLR) family, complement system. Both systems first engage fight against launch whole range aimed at its rapid elimination. Normally, their joint activity destruction pathogen recovery. these can cause an excessive inflammatory dangerous body. turn, inflammation entails activation damage vascular endothelium, as well hypercoagulable state observed seriously ill Activation endothelium hypercoagulation lead thrombosis and, result, tissues. Immune-mediated termed "immunothrombosis". this review, we discuss detail features immunothrombosis associated potential underlying mechanisms.

Language: Английский

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