Using nutrition to help recovery from infections DOI
Inês B. Moura, Anthony M. Buckley

Current Opinion in Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Antibiotics are a cornerstone of modern medicine, but antibiotic consumption can have depleting effects on the gut microbiota, potentially leading to gastrointestinal symptoms and other diseases, namely Clostridioides difficile infection. Because nutrition is major driver microbiota diversity function, here we explore current evidence potential diets in alleviate deleterious antibiotics consumed during infections.

Language: Английский

The Gut–Brain Axis in Schizophrenia: The Implications of the Gut Microbiome and SCFA Production DOI Open Access

Songhyun Ju,

Yoonhwa Shin,

Sunhee Han

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4391 - 4391

Published: Oct. 16, 2023

Schizophrenia, a severe mental illness affecting about 1% of the population, manifests during young adulthood, leading to abnormal function and behavior. Its multifactorial etiology involves genetic factors, experiences adversity, infection, gene-environment interactions. Emerging research indicates that maternal infection or stress pregnancy may also increase schizophrenia risk in offspring. Recent on gut-brain axis highlights gut microbiome's potential influence central nervous system (CNS) health, including schizophrenia. The microbiota, located digestive system, has significant role play human physiology, immune development, vitamin synthesis, protection against pathogenic bacteria. Disruptions caused by diet, medication use, environmental pollutants, stress, lead imbalances with far-reaching effects CNS health. Of interest are short-chain fatty acids (SCFAs), metabolic byproducts produced microbes fermentation. SCFAs can cross blood-brain barrier, influencing activity, microglia cytokine modulation. dysregulation neurotransmitters contribute disorders, This review explores relationship between SCFAs, microbiome, Our aim is deepen understanding elucidate its implications for future therapeutic approaches.

Language: Английский

Citations

33
Protective Effect of Semaglutide on Obesity-Induced Renal Disease and Obesity-Induced Kidney Renal Clear Cell Carcinoma DOI Creative Commons
Shuqi Wang, Mengmeng Zhang, Xiaoman Yang

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 805 - 818

Published: March 1, 2025

Proteomics was used to study the effect of semaglutide on expression renal protein in obese mice, and looking for proteins that could improve prognosis Kidney Renal Clear Cell Carcinoma (KIRC). Thirty-six mice were randomly divided into normal-fat diet group (NFD), high-fat (HFD), plus intervention (HS). Collected serum, urine, kidney tissue samples, detected urinary protein/creatinine, blood glucose, lipid, inflammation, oxidative stress other related indicators. Different staining methods analyze pathological changes mice's kidneys. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis total kidneys mice. Finally, bioinformatics technology significantly different expressed (DEPs). The mechanism protecting phosphorylation, PPAR signaling pathway, thiamine, butyric acid tryptophan metabolism pathways. Moreover, increase Man1a1 Ntn4 while high-expression KIRC population had a better overall survival rate. Semaglutide regulate development by up-adjusting Ntn4.

Language: Английский

Citations

1
Alleviation of fluoride-induced colitis by tea polysaccharides: Insights into the role of Limosilactobacillus vaginalis and butyric acid DOI

Chenjun Zhao,

Guijie Chen, Ying Huang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 134858 - 134858

Published: June 7, 2024

Language: Английский

Citations

8
L-arabinose exerts probiotic functions by improving gut microbiota and metabolism in vivo and in vitro DOI Creative Commons
Shasha Xiang,

Ge Yin,

Yalin Zhang

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 113, P. 106047 - 106047

Published: Feb. 1, 2024

Prior investigations have primarily focused on the impact of L-arabinose gut microbiota, with limited exploration into dual mechanisms microbiota and metabolism both in vivo vitro. Thus, this study aimed to elucidate anti-inflammatory effects 5 % under different diet mice. Additionally, a colon simulation system (CDMN) utilizing 1.72 (w/v) lumen mucus layers, provide further insights underlying mechanisms. The results revealed that significantly altered microbiome structure, particularly elevating Bifidobacterium short-chain fatty acids (SCFAs) Subsequent vitro experiments confirmed increased relative abundance SCFAs-producing bacteria, facilitated linoleic acid metabolism, enhanced downstream metabolites (12,13-DHOME, 9,10-DHOME), potentially mediated by descending colon. These findings underscore role modulating intestinal flora thereby promoting body health.

Language: Английский

Citations

7
Traditional Medicine Xianglian Pill Suppresses high-fat diet-related colorectal cancer via inactivating TLR4/MyD88 by remodeling gut microbiota composition and bile acid metabolism DOI
Chenxiao Ye,

Changhong Wu,

Yan Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118411 - 118411

Published: May 31, 2024

Language: Английский

Citations

7
Gut microbiota, a key to understanding the knowledge gaps on micro-nanoplastics-related biological effects and biodegradation DOI
Jiping Wang, Yutong Wang, Zhenyu Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 944, P. 173799 - 173799

Published: June 11, 2024

Language: Английский

Citations

6
Investigating the Impacts of Diet, Supplementation, Microbiota, Gut–Brain Axis on Schizophrenia: A Narrative Review DOI Open Access

Izabela Zajkowska,

Patrycja Niczyporuk,

Agata Urbaniak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2228 - 2228

Published: July 11, 2024

Schizophrenia is a disease with complex etiology that significantly impairs the functioning of patients. In recent years, there has been increasing focus on importance gut microbiota in context gut-brain axis. our study, we analyzed data axis relation to schizophrenia, as well impacts eating habits, use various supplements, and diets schizophrenia. Additionally, study investigated impact antipsychotics development metabolic disorders, such diabetes, dyslipidemia, obesity. There may be significant clinical benefits gained from therapies supported by supplements omega-3 fatty acids, B vitamins, probiotics. The results suggest need for holistic approach treatment incorporating both drug therapy dietary interventions.

Language: Английский

Citations

5
Lactobacillus johnsonii GLJ001 prevents DSS-induced colitis in mice by inhibiting M1 macrophage polarization via gut microbiota-SCFAs axis DOI

Yunjie Cai,

Yina Huang, Yu Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113671 - 113671

Published: Nov. 30, 2024

Language: Английский

Citations

4
Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease DOI Open Access
Naomi E. Butler Tjaden, Megan J. Liou, Sophie E. Sax

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Enterocolitis is a common and potentially deadly manifestation of Hirschsprung disease (HSCR) but mechanisms remain poorly defined. Unexpectedly, we discovered that diet can dramatically affect the lifespan HSCR mouse model ( Piebald lethal , sl/sl ) where affected animals die from HAEC complications. In model, alters gut microbes metabolites, leading to changes in colon epithelial gene expression oxygen levels known influence colitis severity. Our findings demonstrate unrecognized similarity between other types suggest dietary manipulation could be valuable therapeutic strategy for people with HSCR. birth defect enteric nervous system (ENS) absent distal bowel. Bowel lacking ENS fails relax, causing partial obstruction. Affected children often have "Hirschsprung associated enterocolitis" (HAEC), which predisposes sepsis. We survival mice, well-established HAEC, markedly altered by two distinct standard chow diets. A "Protective" increased fecal butyrate/isobutyrate enhanced production antimicrobial peptides proximal colon. contrast, "Detrimental" diet-fed had abnormal appearing epithelium mitochondria, reduced mRNA involved oxidative phosphorylation, elevated fostered growth inflammation-associated Enterobacteriaceae . Accordingly, selective depletion sodium tungstate prolonged survival. results provide first strong evidence modifies without altering length ENS. Two different diets alter disease, impacting extent aganglionosis (the region ENS). mice fed many transcriptome including decreased genes phosphorylation. Detrimental also aberrant-appearing mitochondria epithelium, drives overgrowth via aerobic respiration. Elimination antibiotics or improves "Detrimental diet".

Language: Английский

Citations

0
Microbial Butyrate Modified by Melatonin Alleviates Colon Inflammation by Inhibiting GPR109A/Caspase-1-Dependent Macrophage M1 Polarization DOI
Xinyu Shao, Xiuwei Mi, Xiaoyi Kuai

et al.

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: 24(4), P. 1871 - 1884

Published: March 5, 2025

Recurrent ulcerative colitis (UC) seriously affects the quality of life patients. Melatonin alteration gut microbiota and can effectively relieve inflammation-associated diseases. In present study, we determined that melatonin alleviated intestinal inflammation delayed weight loss in mice. Analysis ileocecal contents mice via 16S-rRNA GC-MS revealed could elevate diversity abundance short-chain fatty acids producing bacteria promote secretion butyrate. Subsequently, butyrate negatively regulates NLRP3-mediated inflammatory signaling pathway to inhibit proinflammatory mediators such as caspase-1 IL-1β restrict further development inflammation. The NLRP3 expression increased, GPR109A was reduced significantly tissues active UC patients, which also closely related clinical indicators CRP ESR closely. However, disrupting with broad-spectrum antibiotics (ABX) blocks melatonin's role reducing Collectively, indicate arrests by modulating microbiome NLRP3/caspase-1 pathways skew macrophage polarization, may have potential implications new approaches treat acute UC.

Language: Английский

Citations

0