Thoracic Cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 17, 2024
Protein tyrosine kinase 7 (PTK7) has been found to be highly expressed in non-small cell lung cancer (NSCLC), but its specific molecular mechanism needs further explored.
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 14, 2025
Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression. Although more experimental evidence clinical data indicate that macrophages onset progression of oral squamous cell carcinoma (OSCC), exact pathogenesis OSCC associated with has not been fully elucidated. Enhanced knowledge molecular mechanisms involving will aid creation treatments targeted specifically at macrophages. This review outlines pro-tumoral anti-tumoral effects OSCC, emphasizing interaction between It can provide theoretical basis for establishment complex regulatory network centered on explore novel therapeutic strategies OSCC.
Language: Английский
Citations
1
Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101607 - 101607
Published: March 1, 2025
Language: Английский
Citations
0
Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates quality life. Lymph node (LN) metastasis lead contributor to poor prognosis associated with OSCC. SOAT1 plays critical role cholesterol metabolism has been implicated various cancers, although its specific mechanisms OSCC are poorly understood. Additionally, NLRP3 inflammasome identified as factor that promotes progression by influencing processes involved tumor development, activation linked metastasis. Lymphangiogenesis enhancing OSCC, while molecule networks regulating it remains unclear. In our study, we found overexpressed proliferation, migration, invasion cells. Knockdown expression impaired both vitro vivo, reduced rate LN RNA sequencing analysis revealed downstream regulated SOAT1, reactivation having recovered malignancy inhibited knockdown. Furthermore, IL-1β, released activation, could directly bind IL-1R-1 lymphatic endothelial cells (LECs), enhance tube formation capacity LECs, indicating potential promoting lymphangiogenesis conclusion, promote regulate increase via IL-1β/IL-1R-1 axis
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2477 - 2477
Published: Oct. 28, 2024
Objectives: Head and neck squamous cell carcinoma (HNSCC) ranks sixth globally, with a 50% five-year survival rate. SAR1A exhibits high expression levels in various tumor types, yet its specific role HNSCC remains to be clarified. Methods: In vitro assays, such as CCK8, EdU, colony formation, wound-healing, transwell, Western blotting analyses, well vivo xenografts lung metastasis models, were conducted evaluate the impacts of on proliferation, migration, invasion. Transcriptome sequencing KEGG enrichment pathway analysis revealed evident alterations PI3K/AKT/mTOR(PAM) pathways. LY294002 (a PI3K/AKT inhibitor) was used investigate PAM invasion HNSCC. Results: Univariate multivariate Cox regression screen gene prognostic biomarker HNSCC, it validated Cancer Genome Atlas (TCGA) database. Functional assays demonstrated that depletion leads suppressed cells. This is accompanied by decrease epithelial–mesenchymal transition (EMT)-related markers lines. addition, diminished capacities observed knockdown cells reversed upon overexpression SAR1A. Furthermore, RNA-seq significant alteration following knockdown. effectively mitigated increased induced overexpression. Conclusions: facilitates proliferation EMT via PI3K/AKT/mTOR pathway.
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 9, 2024
Language: Английский
Citations
0
Thoracic Cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 17, 2024
Protein tyrosine kinase 7 (PTK7) has been found to be highly expressed in non-small cell lung cancer (NSCLC), but its specific molecular mechanism needs further explored.
Language: Английский
Citations
0