Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression

International Journal of Biological Sciences, Journal Year: 2019, Volume and Issue: 15(11), P. 2320 - 2329

Published: Jan. 1, 2019

Solid tumors consist of various types stromal cells in addition to cancer cells.Cancer-associated fibroblasts (CAFs) are a major component the tumor stroma and play an essential role progression metastasis variety malignancies, including gastric cancer.However, effects CAFs on cells' not well studied.Here we show that matrix metalloproteinase 11 (MMP11) exosomes secreted from can be delivered into cells.Gastric promote cell migration partially through exosomal MMP11.Moreover, MMP11 is overexpressed purified plasma patients tissues associated with overall survival patients.We also find negatively regulated by miR-139 cancer.Exosomal inhibits growth decreasing expression vitro vivo.Thus, propose derived could inhibit microenvironment.

Language: Английский

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Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases

Cells, Journal Year: 2020, Volume and Issue: 9(5), P. 1212 - 1212

Published: May 13, 2020

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix (ECM) resulting in scar tissue formation, are a growing health problem causing increasing morbidity and mortality worldwide. Currently, therapeutic options for fibrosis severely limited, organ transplantation is the only treatment end-stage diseases. During damage, injured hepatocytes release proinflammatory factors recruitment activation immune cells that activate quiescent hepatic stellate (HSCs). Upon activation, HSCs transdifferentiate into highly proliferative, migratory, contractile ECM-producing myofibroblasts. The disrupted balance between ECM deposition degradation leads to formation referred as fibrosis. This can be restored either reducing (by inhibition proliferation) or enhancing increased expression metalloproteinases (MMPs)). MMPs play important role remodeling represent interesting target drug discovery. In this review, we present current knowledge about different MMP patterns stages diseases have also been reviewed determine their biomarkers. Finally, highlight promising targets resolution

Language: Английский

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The paradoxical role of matrix metalloproteinase-11 in cancer

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111899 - 111899

Published: July 30, 2021

The microenvironment surrounding the tumor affects biological processes, such as cell proliferation, angiogenesis, apoptosis, and invasion. Therefore, ability to change these environments is an important attribute for cells obtain specific functions necessary growth metastasis. Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic metalloenzymes that facilitate protease-dependent progression by degrading extracellular matrix (ECM) proteins, releasing cytokines, factors, other surface molecules. As one of most widely studied MMPs, MMP-11 protease expressed in cancer cells, stromal adjacent microenvironment. has a dual effect on tumors. On hand, promotes development inhibiting apoptosis promoting migration invasion early stage. animal models, protective metastasis at advanced Based current findings regarding importance altering microenvironment, there need further understand how ECM regulate progression, which may result re-examination MMPs drug targets diseases. In this review, we summarize role its potential clinical significance.

Language: Английский

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Single Nucleotide Polymorphism

Published: Jan. 1, 2024

Primary hepatic cancer (PHC) is a common malignant tumor and the third most frequent cause of cancer-related death worldwide. However, molecular mechanisms underlying remain unknown.

Language: Английский

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Exploring the Impact of Different Inflammatory Cytokines on Hepatitis C Virus Infection

Journal of Interferon & Cytokine Research, Journal Year: 2024, Volume and Issue: 44(6), P. 233 - 243

Published: April 2, 2024

Hepatitis C virus (HCV) infection is a global health concern affecting millions worldwide. Chronic HCV often leads to liver inflammation and can progress cirrhosis hepatocellular carcinoma. Inflammatory cytokines are crucial in modulating the immune response during infection. This review aims investigate impact of different inflammatory on associated responses.

Language: Английский

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Gene Therapy for Liver Cancers: Current Status from Basic to Clinics

Cancers, Journal Year: 2019, Volume and Issue: 11(12), P. 1865 - 1865

Published: Nov. 25, 2019

The liver is a key organ for metabolism, protein synthesis, detoxification, and endocrine function, among diseases, including hepatitis, cirrhosis, malignant tumors, congenital disease, cancer one of the leading causes cancer-related deaths worldwide. Conventional therapeutic options such as embolization chemotherapy are not effective against advanced-stage cancer; therefore, continuous efforts focus on development novel options, molecular targeted agents gene therapy. In this review, we will summarize progress toward therapies cancer, with an emphasis recent clinical trials preclinical studies.

Language: Английский

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Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(14), P. 4906 - 4906

Published: July 11, 2020

Liver fibrosis is one of the risk factors for hepatocellular carcinoma (HCC) development. The staging liver can be evaluated only via a biopsy, which an invasive procedure. Noninvasive methods diagnosis divided into morphological tests such as elastography and serum biochemical tests. Transient reported to have excellent performance in has been accepted useful tool prediction HCC development other clinical outcomes. Two-dimensional shear wave new technique provides real-time stiffness image. Serum markers studied based on mechanism fibrogenesis fibrolysis. In healthy liver, homeostasis extracellular matrix maintained directly by enzymes called metalloproteinases (MMPs) their specific inhibitors, tissue inhibitors (TIMPs). MMPs TIMPs could biomarkers promising candidates treatment fibrosis. Further studies are required establish fibrosis-specific further molecular research. this review, we summarize noninvasive current daily practice.

Language: Английский

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LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 9, 2021

Abstract Background Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying mechanisms LINC00221 in HCC. Methods results Human HCC samples had increased expression LINC00221. Effects on cellular functions were analyzed using gain- loss-function approaches. knockdown repressed cell growth, migration, invasion enhanced their apoptosis. This anti-tumor effect validated vivo. Online prediction showed potential binding relationship between let-7a-5p, as well let-7a-5p matrix metalloproteinase 11 (MMP11). The luciferase, immunoprecipitation, pull-down assays interacted with increase MMP11. Furthermore, demonstrated silencing inhibited MMP11 expression, thereby delaying progression vitro. Conclusions Silencing could prevent via upregulating downregulating As such, inhibition presents a promising antitumor strategy for treatment

Language: Английский

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Impact of WNT1-inducible signaling pathway protein-1 (WISP-1) genetic polymorphisms and clinical aspects of breast cancer

Medicine, Journal Year: 2019, Volume and Issue: 98(44), P. e17854 - e17854

Published: Nov. 1, 2019

Abstract Breast cancer is the most common diagnosed malignancy in women. This study genotyped blood samples from 236 Han Chinese women with breast and 128 healthy controls for single nucleotide polymorphisms (SNPs) rs2977537, rs2929970, rs2929973, rs2977530, rs62514004, to determine whether these WNT1-inducible signaling pathway protein 1 ( WISP-1 ) genetic increase risk of developing cancer. Compared wild-type (AA) carriers, those carrying WISP1 rs62514004 AG or + GG variants had a greater In an evaluation association between clinicopathological aspects SNP cohort, patients genotype were less likely than AA develop stage III/IV disease. Patients rs2929973 TT variant almost twice as GT have estrogen receptor (ER)- progesterone (PR)-positive tumors, while around HER2-positive tumors. details associations SNPs susceptibility ethnicity.

Language: Английский

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Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(22), P. 8603 - 8603

Published: Nov. 19, 2020

Prostate cancer is among the most common malignant tumors worldwide. Matrix metalloproteinase (MMP)-11 involved in extracellular matrix degradation and remodeling plays an essential role development metastasis. This study investigated association of MMP-11 polymorphisms with clinicopathological characteristics biochemical recurrence prostate cancer. Five single-nucleotide (SNPs) were analyzed 578 patients through real-time polymerase chain reaction analysis. A prostate-specific antigen level >10 ng/mL, Gleason grade groups 4 + 5, advanced tumor stage, lymph node metastasis, invasion, high-risk D’Amico classification significantly associated (p < 0.001). rs131451 “TC CC” polymorphic variants clinical stage (T stage; p = 0.007) 0.015) recurrence. These findings demonstrate that not susceptibility; however, variant was late-stage Thus, SNP may contribute to

Language: Английский

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