Low temperature photothermal therapy: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214330 - 214330

Published: Dec. 2, 2021

Language: Английский

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Unveiling the potential effects of resveratrol in lung cancer treatment: Mechanisms and nanoparticle-based drug delivery strategies

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 172, P. 116207 - 116207

Published: Jan. 31, 2024

Lung cancer ranks among the most prevalent forms of and remains a significant factor in cancer-related mortality across world. It poses challenges to healthcare systems society as whole due its high incidence, rates, late-stage diagnosis. Resveratrol (RV), natural compound found various plants, has shown potential nanomedicine for lung treatment. RV varied effects on cells, including promoting apoptosis by increasing pro-apoptotic proteins (Bax Bak) decreasing anti-apoptotic (Bcl-2). also hinders cell proliferation influencing important signaling pathways (MAPK, mTOR, PI3K/Akt, Wnt/β-catenin) that govern progression. In addition, acts potent antioxidant, diminishing oxidative stress safeguarding cells against DNA damage. However, using alone treatment drawbacks, such low bioavailability, lack targeting ability, susceptibility degradation. contrast, nanoparticle-based delivery address these limitations hold promise improving outcomes cancer; nanoparticle formulations offer advantages improved drug delivery, increased stability, controlled release, targeted cells. This article will provide an overview cancer, explore therapeutic agent, discuss benefits highlight nanoparticles treatment, cancer. By optimizing clinical application, future studies aim enhance overall improve prognosis patients.

Language: Английский

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Molecular Chaperonin HSP60: Current Understanding and Future Prospects

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5483 - 5483

Published: May 17, 2024

Molecular chaperones are highly conserved across evolution and play a crucial role in preserving protein homeostasis. The 60 kDa heat shock (HSP60), also referred to as chaperonin (Cpn60), resides within mitochondria is involved maintaining the organelle’s proteome integrity HSP60 family, encompassing Cpn60, plays diverse roles cellular processes, including folding, cell signaling, managing high-temperature stress. In prokaryotes, well understood GroEL/GroES complex, which forms double-ring cavity aids folding. eukaryotes, implicated numerous biological functions, like facilitating folding of native proteins influencing disease development processes. Notably, research highlights its critical involvement sustaining oxidative stress mitochondrial integrity. perturbation results loss activates apoptosis. Currently, clinical investigations progress explore targeting both vivo vitro various models. These studies aim enhance our comprehension mechanisms potentially harness therapeutic target for conditions, cancer, inflammatory disorders, neurodegenerative diseases. This review delves into functions regulating proteo-homeostasis, stress, ROS, apoptosis, implications diseases cancer neurodegeneration.

Language: Английский

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Harnessing tomato-derived small extracellular vesicles as drug delivery system for cancer therapy

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 7, 2025

Aim This study aims to explore a sustainable and scalable approach using tomato fruit-derived sEVs (TsEVs) deliver calcitriol for enhanced anticancer effects, addressing challenges of low yield high costs associated with mammalian cell-derived sEVs.

Language: Английский

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Translational Advances in the Field of Pulmonary Hypertension.From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2016, Volume and Issue: 195(4), P. 425 - 437

Published: Sept. 14, 2016

Language: Английский

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MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis

Molecular Cancer, Journal Year: 2017, Volume and Issue: 16(1)

Published: Jan. 17, 2017

Cancer metastasis is determined by the formation of metastatic niche and ability cancer cells to adapt microenvironmental stresses. Anoikis resistance a fundamental feature cell survival during progression. However, mechanisms underlying anoikis in ovarian are still unclear.Expressions miRNA-141 its downstream targets were evaluated qPCR, Western blotting, Immunohistochemical (IHC) situ hybridization (ISH) assays. The luciferase assays used prove KLF12 as target miR-141. cDNA microarray apoptotic protein arrays identify miR-141 KLF12. competition Sp1 on survivin promoter was examined ChIP assay. IHC analysis tissue array evaluate expressions show clinical relevance. functional studies performed vitro vivo tumorigenic assays.Enforced expression promotes, while knockdown inhibits, proliferation, anchorage-independent capacity, resistance, tumor growth peritoneal metastases cells. Bioinformatics identified that Kruppel-related zinc finger AP-2rep (KLF12) directly targeted Consistent with this finding, phenocopied effects overexpression In contrast, restoration miR-141-expressing significantly attenuated via interfering Sp1-mediated transcription, which inhibits intrinsic pathway crucial for survival, metastases. confirmed inversely correlated associated advanced cancers accompanied distal metastases, underscoring relevance our findings.Our data novel signaling axis miR-141/KLF12/Sp1/survivin enhancing likely serves potential therapeutic cancer.

Language: Английский

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Microtubules in 3D cell motility

Journal of Cell Science, Journal Year: 2017, Volume and Issue: 130(1), P. 39 - 50

Published: Jan. 1, 2017

ABSTRACT Three-dimensional (3D) cell motility underlies essential processes, such as embryonic development, tissue repair and immune surveillance, is involved in cancer progression. Although the cytoskeleton a well-studied regulator of migration, most what we know about its functions originates from studies conducted two-dimensional (2D) cultures. This research established that microtubule network mediates polarized trafficking signaling are crucial for shape movement 2D. In parallel, developments light microscopy 3D culture systems progressively allowed to investigate cytoskeletal more physiologically relevant settings. Interestingly, several have demonstrated involvement morphogenesis can differ 2D environments. this Commentary, discuss these differences their relevance understanding role microtubules migration vivo. We also provide an overview were shown control matrices how they be investigated further by using models.

Language: Английский

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Markers of Oral Lichen Planus Malignant Transformation

Disease Markers, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 13

Published: Jan. 1, 2018

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients’ quality life. Malignant transformation into oral squamous cell carcinoma (OSCC) considered as one the most serious complications disease; nevertheless, controversy still persists. Various factors seem to be involved in progression malignant transformation; however, mechanism this process not fully understood yet. Molecular alterations detected OLP samples might represent useful biomarkers for predicting and monitoring progression. In review, we discuss various studies which highlight different molecules ominous predictors transformation.

Language: Английский

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Toward early cancer detection: Focus on biosensing systems and biosensors for an anti-apoptotic protein survivin and survivin mRNA

Biosensors and Bioelectronics, Journal Year: 2019, Volume and Issue: 137, P. 58 - 71

Published: May 8, 2019

Language: Английский

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Significance of Tumor Mutation Burden in Immune Infiltration and Prognosis in Cutaneous Melanoma

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: Sept. 18, 2020

Background: Melanoma is highly immunogenic and therefore suitable for immunotherapy, but the efficacy limited by response rate. In several types of tumor, tumor mutation burden (TMB) immune infiltration have been reported to predict although each has its limitations. current study, we aimed explore association TMB with prognosis in melanoma. Methods: The data melanoma used analyses was downloaded from Cancer Genome Atlas (TCGA) database. sorted using "maftools" R package. estimated then patients were divided into two groups based on TMB. clinical characteristics explored. Differential analysis between performed "DESeq2" package identify differentially expressed genes (DEGs). function enrichment DEGs conducted screen critical pathways. Besides, further filtered hub genes, which a risk score model nomogram predicting conducted, validation three datasets Gene Expression Omnibus (GEO) Finally, CIBERSORT algorithm TIMER database assess effect infiltration. Results: most common C > T, top frequently mutated TTN, MUC16, BRAF. Higher indicated better survival outcomes lower pathological stages. 735 identified mainly involved immune-related adhesion-related validated receiver operating characteristic (ROC) curves calibration curves, exhibited relatively high predictive capability. Decision curve (DCA) benefit. As infiltration, proportion higher macrophages M1 M2 high-TMB group, while memory B cells regulatory T cells. Conclusions: cutaneous melanoma, positively correlated prognosis. can be conveniently help improve methods immunotherapy.

Language: Английский

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