Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives DOI
Añil Sharma, Deeksha Pal,

Anita Rani Gill

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 24, 2024

Language: Английский

The protective role of baicalin regulation of autophagy in cancers DOI Creative Commons
Qí Zhāng,

Shiyun Guo,

Han Ge

et al.

Cytotechnology, Journal Year: 2025, Volume and Issue: 77(1)

Published: Jan. 3, 2025

Language: Английский

Citations

1
Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment DOI Creative Commons
Qinan Yin,

Si-Yuan Song,

Yuan Bian

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 14, 2024

Background The interaction between pyroptosis—a form of programmed cell death—and tumor immunity represents a burgeoning field interest. Pyroptosis exhibits dual role in cancer: it can both promote development and counteract by activating immune responses that inhibit evasion encourage death. Current immunotherapy strategies, notably CAR-T therapy checkpoint inhibitors (ICIs), alongside the potential certain traditional Chinese medicinal compounds, highlight intricate relationship pyroptosis cancer immunity. As research delves deeper into mechanisms within therapy, its application enhancing emerges as novel avenue. Purpose This review aims to elucidate underlying pyroptosis, impact on biology, advancements research. Methods A comprehensive literature was conducted across PubMed, Embase, CNKI, Wanfang Database from inception study until August 22, 2023. search employed keywords such “pyroptosis”, “cancer”, “tumor”, “mechanism”, “immunity”, “gasdermin”, “ICB”, “CAR-T”, “PD-1”, “PD-L1”, “herbal medicine”, “botanical “Chinese “traditional “immunotherapy”, linked AND/OR, capture latest findings immunotherapy. Results is governed complex mechanism, with Gasdermin family playing pivotal role. While promising for application, pyroptosis’s effect still evolving. Notably, medicine ingredients have been identified inducers, meriting further exploration. Conclusion consolidates current knowledge It reveals beneficial factor immunotherapeutic landscape, suggesting leveraging developing treatment including those involving medicine, forward-looking approach oncology.

Language: Английский

Citations

4
Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease DOI Creative Commons

Lujia Si,

Yu Lai

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 9, 2024

Baicalin is a flavonoid glycoside obtained from the dried root of

Language: Английский

Citations

4
Analysis of prognostic biomarker models of TXNIP/NLRP3/IL1B inflammasome pathway in patients with acute myeloid leukemia DOI Creative Commons
Junjie Chen,

Qi Hou,

Tao Chang

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(8), P. 1438 - 1446

Published: Jan. 1, 2024

Exploring potential biomarkers for predicting clinical outcomes and developing targeted therapies acute myeloid leukemia (AML) is of utmost importance. This study aimed to investigate the expression pattern thioredoxin-interacting protein (TXNIP)/nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3) pathway its role in prognosis AML patients.

Language: Английский

Citations

3
The efficacy and safety of pH‐responsive and photothermal‐sensitive multifunctional nanoparticles loaded with cryptotanshinone for the treatment of gastric cancer DOI
Dan Wu,

M Chen,

Nan Zheng

et al.

Molecular Carcinogenesis, Journal Year: 2024, Volume and Issue: 63(12), P. 2346 - 2362

Published: Aug. 26, 2024

Abstract A multifunctional polydopamine/mesoporous silica nanoparticles loaded cryptotanshinone (PDA/MSN@CTS) was synthesized and subjected to investigating its physicochemical properties anti‐gastric cancer (GC) effects. Utilizing network pharmacology molecular docking techniques, CTS identified as our final research target. The structural morphology of PDA/MSN@CTS were examined. Near‐infrared (NIR) laser employed evaluate the photothermal PDA/MSN@CTS, along with pH‐responsive NIR‐triggered release assessments. In vitro experiments evaluated impact on malignant behavior AGS gastric cells. subcutaneous tumor model further established in vivo safety PDA/MSN@CTS. Furthermore, efficacy addition combined effect therapy (PTT), investigated. Uniform stable had been successfully demonstrated efficient under environment NIR irradiation. Upon increasing conditions, cytotoxicity, apoptosis rate, reactive oxygen species scavenging ability, suppression migration invasion cells by significantly enhanced. assessments revealed excellent blood compatibility biosafety alongside robust tissue targeting. Combining PTT facilitated anti‐GC effects Compared free drugs, exhibits higher selectivity towards cells, demonstrating effective anticancer activity biocompatibility both vivo. nanomaterial possesses properties, synergistic therapeutic

Language: Английский

Citations

3
Research progress on molecular mechanism of liver metastasis of gastric cancer and treatment with traditional Chinese medicine DOI Creative Commons
Caiyue Liu, Zheng Li,

F Cheng

et al.

Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(6), P. 1944 - 1957

Published: March 3, 2025

Gastric cancer liver metastasis (GCLM) refers to the process of cells from stomach spreading liver, which is an important sign deterioration gastric (GC) and has a profound influence on treatment prognosis patients. Once GC metastasis, becomes more complex challenging, seriously affects survival rate patients with GC. Therefore, studying mechanism GCLM extremely necessary. At present, continuous research revealed that its occurrence development involves comprehensive effect multiple targets links. Traditional Chinese medicine (TCM) advantages wide sources, excellent efficacy, small toxicity side effects, have become focus current antitumor research. TCM, monomers, or TCM compounds can inhibit growth In recent years, made substantial achievements in experimental intervention GCLM. This article reviews progress mechanism.

Language: Английский

Citations

0
NLRP3 inflammasome-based therapies by natural products: a new development in the context of cancer therapy DOI
Hamza Abu Owida, Ahmed Abed, Farag M. A. Altalbawy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis DOI

Shaocong Wang,

Xinzhe Chen, Kun Wang

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors DOI Creative Commons
Kangning Zhao, Jinlong Zhang, Lin Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Scutellaria baicalensis has been used for the treatment of digestive system disorders thousands years in China and other regions. Modern research have revealed its therapeutic efforts tumors. Thus, to review updated progress S. main flavonoids tumors past 10 years, this article summarized effect molecular mechanisms 5 on oral cavity, esophagus, stomach, colon, liver, pancreas by inhibiting tumor cell proliferation, inducing autophagy, stimulating immune response, increasing drug sensitivity. In conclusion, could be applied treat with different type methods.

Language: Английский

Citations

2
Unraveling the NLRP Family: Structure, Function, Activation, Critical Influence on Tumor Progression, and Potential as Targets for Cancer Therapy DOI
Xueqing Zhou, Yongguang Tao, Yongyong Shi

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217283 - 217283

Published: Oct. 1, 2024

Language: Английский

Citations

1