Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 9, 2023

Abstract Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration. A variety neuromodulation techniques that regulate regional brain activities have been used to treat refractory mood disorders. However, their efficacy varies from person lack reliable indicator. This review summarizes clinical animal studies on inflammation in neural circuits related anxiety depression evidence therapies neuroinflammation treatment neurological diseases. Neuromodulation therapies, including transcranial magnetic stimulation (TMS), electrical (TES), electroconvulsive therapy (ECT), photobiomodulation (PBM), ultrasound (TUS), deep (DBS), vagus nerve (VNS), all reported attenuate reduce release pro-inflammatory factors, which may be one reasons for improvement. provides a better understanding effective mechanism indicates inflammatory biomarkers serve as reference assessment pathological conditions options depression.

Language: Английский

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Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

Theranostics, Journal Year: 2022, Volume and Issue: 12(5), P. 2205 - 2231

Published: Jan. 1, 2022

Alzheimer's disease (AD) is the most common form of dementia in elderly, causing neuronal degeneration and cognitive deficits that significantly impair independence quality life for those affected their families.Though AD a major neurodegenerative with vast avenues investigation, there no effective treatment to cure or slow progression.The present work evaluated therapeutic effect long-term photobiomodulation (PBM) continuous-wave low-level laser on its underlying mechanism.Methods: PBM was implemented 2 min, 3 times per week 16 months 2-month-old transgenic rats.A battery behavioral tests performed measure dysfunction rats.The effects therapy typical pathologies, including amyloid plaques, intracellular neurofibrillary tangles, loss, injury, apoptosis, neurodegeneration, were then assessed.The mechanisms measured using immunofluorescence staining, western blotting analysis, mass spectrometry, primary cortical hippocampal cell cultures, related assay kits.Results: improved pathologies memory tau hyperphosphorylation, degeneration, spine damage, synaptic loss.PBM had several mechanistic which may explain these beneficial effects, 1) regulation glial polarization inhibition neuroinflammation, 2) preservation mitochondrial dynamics by regulating fission fusion proteins, 3) suppression oxidative damage DNA, lipids.Furthermore, enhanced recruitment microglia surrounding plaques improving expression microglial IL-3Rα astrocytic IL-3, implies potential role Aβ clearance.Finally, our results implicate hemoglobin mediating neuroprotective PBM, as Hbα knockdown abolished treatment.Conclusion: Collectively, data supports use prevent progression provides new insights into molecular therapy.

Language: Английский

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High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization

Theranostics, Journal Year: 2023, Volume and Issue: 13(10), P. 3434 - 3450

Published: Jan. 1, 2023

Background: Alzheimer's disease (AD), one of the most common forms dementia, is a widely studied neurodegenerative characterized by Aβ accumulation and tau hyperphosphorylation. Currently, there no effective cure available for AD.The astrocyte AQP4 polarized distribution-mediated glymphatic system essential abnormal clearance potential therapeutic target AD.However, role exercise on distribution association between phenotype polarization are poorly understood.Methods: Using streptozotocin (STZ)-induced sporadic AD rat model, we investigated effects high-intensity interval training pathologies.The Branes maze task was conducted to measure spatial learning memory.Immunofluorescence staining NeuN with TUNEL, Fluoro-Jade C, relative neuronal damage markers applied apoptosis, neurodegeneration, damage.Sholl analysis carried out analyze morphology microglia.Line-scan analysis, 3D rendering, orthogonal view were colocalization.Western blot enzyme-linked immunosorbent assay (ELISA) examine Aβ, respectively.An APP/PS1 transgenic mice model used confirm key findings.Results: High-intensity (HIIT) alleviates cognitive dysfunction in STZ-induced AD-like models provides neuroprotection against damage, loss.Additionally, HIIT improved drainage from cortex hippocampus via kidney.Further mechanistic studies support that beneficial might be due, part, glial cells neurotoxic towards neuroprotective phenotype.Furthermore, an intriguing finding our study strongly correlated phenotype.We found A2 exhibited more evident than A1 phenotype. Conclusion:Our findings indicate ameliorates disease-like pathology regulating phenotype-associated polarization.These changes promote p-tau brain tissue through kidney.

Language: Английский

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Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease

GeroScience, Journal Year: 2022, Volume and Issue: 44(3), P. 1457 - 1477

Published: Feb. 28, 2022

Language: Английский

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Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges

Inflammation and Regeneration, Journal Year: 2022, Volume and Issue: 42(1)

Published: Oct. 3, 2022

Abstract Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and most common form dementia. Characterized by loss learning, memory, problem-solving, language, other thinking abilities, AD exerts a detrimental effect on both patients’ families’ quality life. Although there have been significant advances in understanding mechanism underlying pathogenesis progression AD, no cure for AD. The failure numerous molecular targeted pharmacologic clinical trials leads to an emerging research shift toward non-invasive therapies, especially multiple treatments. In this paper, we reviewed widely studied including photobiomodulation (PBM), transcranial magnetic stimulation (TMS), direct current (tDCS), exercise therapy. Firstly, pathological changes challenges studies. We then introduced these therapies discussed factors that may affect effects therapies. Additionally, review possible mechanisms effects. Finally, summarized treatments future studies applications. concluded it would be critical understand exact find optimal treatment parameters improve translational value Moreover, combined use also promising direction sheds light or prevention

Language: Английский

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Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 22, 2023

Abstract Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once brain injured in various neuropathological conditions or diseases. Photobiomodulation therapy a type noninvasive physical that gradually emerging field neuroscience. Transcranial photobiomodulation has been commonly used to regulate neural activity superficial cortex. To stimulate deeper activity, advanced techniques conjunction with photosensitive nanoparticles have developed. This review addresses mechanisms on neurons and networks discusses advantages, disadvantages potential applications alone combination nanoparticles. its associated strategies may provide new breakthrough treatments for improvement.

Language: Английский

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Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 11, 2025

Repeated closed-head injuries (rCHI) from activities like contact sports, falls, military combat, and traffic accidents pose a serious risk due to their cumulative impact on the brain. Often, rCHI is not diagnosed until symptoms of irreversible brain damage appear, highlighting need for preventive measures. This study assessed prophylactic efficacy remote photobiomodulation (PBM) targeted at lungs against rCHI-induced injury associated behavioral deficits. Utilizing "Marmarou" weight-drop model, was induced in rats days 0, 5, 10. Remote PBM, employing an 808 nm continuous wave laser, administered daily 2-min sessions per lung side over 20 days. Behavioral deficits were through three-chamber social interaction, forced swim, grip strength, open field, elevated plus maze, Barnes maze tests. Immunofluorescence staining 3D reconstruction evaluated neuronal damage, apoptosis, degeneration, morphology microglia astrocytes, as well astrocyte microglia-mediated excessive synapse elimination. Additionally, 16S rDNA amplicon sequencing analyzed changes microbiome following PBM treatment. Results demonstrated that significantly improved depressive-like behaviors, motor dysfunction, interaction impairment while enhancing strength reducing degeneration by rCHI. Analysis revealed enrichment lipopolysaccharide (LPS) biosynthesis pathways, suggesting potential link neuroprotection. Furthermore, mitigated hyperactivation cortical astrocytes reduced synaptic phagocytosis these cells, its strategy with neuroprotective effects.

Language: Английский

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Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 20, 2022

Neuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) gaining prominence because its beneficial effects found in experimental brain research. We systematically reviewed PBM on laboratory animal models, specially to investigate potential benefits an efficient anti-inflammatory therapy.We conducted systematic search bibliographic databases (PubMed ScienceDirect) with keywords based MeSH terms: photobiomodulation, low-level laser therapy, brain, inflammation, cytokine, microglia. Data was limited from 2009 June 2022. followed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guideline. The initial identified 140 articles. them, 54 articles were removed duplication 59 by screening. Therefore, 27 studies met inclusion criteria.The showed has properties several conditions, traumatic injury, edema formation hyperalgesia, ischemia, neurodegenerative aging, epilepsy, depression, spinal cord injury.Taken together, these results indicate transcranial therapy promising strategy treat pathological conditions induced neuroinflammation.

Language: Английский

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Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3

Cell & Bioscience, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 12, 2023

Temporal lobe epilepsy (TLE) remains one of the most drug-resistant focal epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss synaptic proteins neuronal death appear represent a pathogen that characterizes neurobiology TLE. Photobiomodulation (PBM) is rapidly growing therapy for attenuation degeneration harboring non-invasiveness benefits. However, detailed effects PBM on or remain unclear. We investigated whether tPBM exerts neuroprotective hippocampal neurons in mouse model by regulating synapse synapse-related genes.In an vitro study, we performed imaging analysis western blot primary from embryonic (E17) rat pups. In vivo RNA sequencing was identify gene regulatory PBM. Histological stain immunohistochemistry analyses were used assess connections, survival. Behavioral tests evaluate cognitive functions.PBM upregulated connections vitro. addition, it confirmed transcranial reduced degeneration, apoptosis, vivo. These supported results showing relation with networks functions. Specifically, Nlgn3 showed increase after silencing reversed positive effect Lastly, behavioral alterations including hypoactivity, anxiety impaired memory recovered along reduction seizure score PBM-treated mice.Our findings demonstrate attenuates epileptic excitotoxicity, neurodegeneration decline induced TLE through inhibition decrease excitotoxicity.

Language: Английский

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Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 60(4), P. 1749 - 1765

Published: Dec. 26, 2022

Language: Английский

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