Conditioned medium derived from human dental pulp stem cells and photobiomodulation improves lipopolysaccharide-induced neuroinflammation, oxidative stress and cognitive impairment in rats DOI Creative Commons
Mohammad Rezaei, Alireza Ebrahimzadeh‐Bideskan, Mahmoud Hosseini

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 20, 2023

Abstract Neuroinflammation has been introduced as a main player in the development of neurodegenerative disorders. Recent studies showed promising anti-inflammatory role for conditioned medium (CM) nervous system. However, order to improve effects CM this study, we investigated effect and photobiomodulation (PBM) on neuroinflammation cognitive disorders caused by it. model was induced lipopolysaccharide (LPS) injection male Wistar rats. Morris water maze (MWM), Passive Avoidance (PA), probe tests were performed assess memory learning function. Levels malondialdehyde (MDA), thiol, superoxide dismutase (SOD) well acetylcholinesterase (AchE) enzyme activity interleukin-6 (IL-6) measured hippocampus tissue stress oxidative inflammation status, respectively. LPS aggrevated status. Employment PBM led significant increase time traveled distance MWM test, duration remaining dark space PA presence test. treatment also improved LPS-induced markers status attenuated IL-6 level AchE activity. Our results propose potential PBM, alone or combination with CM, impairment. The therapeutic capacity application should be further neuroinflammation-induced major

Language: Английский

Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics DOI Creative Commons
Shaoyi Fang,

Zhibin Wu,

Yali Guo

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 10, 2023

Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells in the dentate gyrus (DG) to complement and repair circuits, thus benefiting treatment of depression. Increasing evidence has shown that aberrant microglial activity can disrupt appropriate formation development properties neurogenesis, which will play a crucial role occurrence However, mechanisms crosstalk between microglia adult depression are not yet fully understood. Therefore, this review, we first introduce recent discoveries regarding roles etiology Then, systematically discuss possible how regulate according studies, involve toll-like receptors, polarization, fractalkine-C-X3-C motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, microbiota-gut-brain etc. In addition, summarize promising drugs could improve by regulating microglia. These findings help us understand complicated pathological shed light on new strategies for disease.

Language: Английский

Citations

35
Traumatic Brain Injury Recovery with Photobiomodulation: Cellular Mechanisms, Clinical Evidence, and Future Potential DOI Creative Commons
Lew Lim

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 385 - 385

Published: Feb. 23, 2024

Traumatic Brain Injury (TBI) remains a significant global health challenge, lacking effective pharmacological treatments. This shortcoming is attributed to TBI’s heterogeneous and complex pathophysiology, which includes axonal damage, mitochondrial dysfunction, oxidative stress, persistent neuroinflammation. The objective of this study analyze transcranial photobiomodulation (PBM), employs specific red near-infrared light wavelengths modulate brain functions, as promising therapy address pathophysiology in single intervention. reviews the feasibility therapy, firstly by synthesizing PBM’s cellular mechanisms with each identified pathophysiological aspect. outcomes human clinical studies are then reviewed. findings support potential for treating TBI, notwithstanding variations parameters such wavelength, power density, dose, source positioning, pulse frequencies. Emerging data indicate that these plays role outcomes. Additionally, new research into effects on electrical properties polymerization dynamics neuronal microstructures, like microtubules tubulins, provides insights future parameter optimization. In summary, PBM represents multifaceted therapeutic intervention TBI vast may be fulfilled optimizing parameters. Future should investigate parameters, possible incorporating artificial intelligence.

Language: Английский

Citations

17
Epilepsy: Mitochondrial connections to the ‘Sacred’ disease DOI Creative Commons
Walter H. Moos, Douglas V. Faller,

Ioannis P. Glavas

et al.

Mitochondrion, Journal Year: 2023, Volume and Issue: 72, P. 84 - 101

Published: Aug. 13, 2023

Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated biomarkers specific for myriad forms epilepsy makes diagnosis challenging. Diagnosis and monitoring childhood add to the need non-invasive biomarkers, especially when evaluating antiseizure medications. Although underlying mechanisms epileptogenesis are not fully understood, evidence mitochondrial involvement is substantial. Seizures affect 35%-60% patients diagnosed with diseases. Mitochondrial dysfunction pathophysiological in various epilepsies, including those non-mitochondrial origin. Decreased ATP production caused by malfunctioning brain cell mitochondria leads altered neuronal bioenergetics, metabolism neurological complications, Iron-dependent lipid peroxidation initiates ferroptosis, a death pathway that aligns morphology found neurodegenerative diseases (NDDs). Studies mouse genetic models seizure phenotypes where function an essential selenoprotein (GPX4) targeted suggest roles ferroptosis epilepsy. GPX4 pivotal NDDs, selenium protects interneurons ferroptosis. Selenium central nervous system micronutrient trace element. Low serum concentrations other elements minerals, iron, noted diagnosing supplements alleviate intractable seizures children reduced GPX activity. Copper cuproptosis, like iron link NDDs. Connecting these mechanistic pathways selenoproteins provides new insights into treating seizures, pointing using medicines prodrugs lipoic acid treat potential alternative therapeutic approaches transcranial magnetic stimulation (transcranial), photobiomodulation vagus nerve stimulation.

Language: Английский

Citations

17
Brain–gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation DOI Creative Commons
Anna Sancho‐Balsells,

Sara Borràs‐Pernas,

Francesca Flotta

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 354, P. 574 - 588

Published: March 14, 2024

Chronic stress is an important risk factor for the development of major depressive disorder (MDD). Recent studies have shown microbiome dysbiosis as one pathogenic mechanisms associated with MDD. Thus, it to find novel non-pharmacological therapeutic strategies that can modulate gut microbiota and brain activity. One such strategy photobiomodulation (PBM), which involves non-invasive use light.

Language: Английский

Citations

5
Photobiomodulation of Neurogenesis through the Enhancement of Stem Cell and Neural Progenitor Differentiation in the Central and Peripheral Nervous Systems DOI Open Access
So‐Young Chang, Min Young Lee

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15427 - 15427

Published: Oct. 21, 2023

Photobiomodulation (PBM) is the regulation of biological processes using light energy from sources such as lasers or light-emitting diodes. Components nervous system, brain and peripheral nerves, are important candidate PBM targets due to lack therapeutic modalities for complete cure neurological diseases. can be applied either regenerate damaged organs prevent reduce damage caused by disease. Although recent findings have suggested that neural cells regenerated, which contradicts our previous understanding, structures still thought weaker regenerative capacity than other systems. Therefore, enhancing system would aid future development therapeutics degeneration. has been shown enhance cell differentiation stem progenitor near-target target cells. In this review, we reviewed research on effects neurogenesis in central (e.g., animal brains) sensory structures) sought its potential a tool intractable degenerative disorders.

Language: Английский

Citations

10
Photobiomodulation using an 830-nm laser alleviates hippocampal reactive gliosis and cognitive dysfunction in a mouse model of adolescent chronic alcohol exposure DOI
Namgue Hong,

Sung-Ryeong Yoon,

Jin‐Chul Ahn

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 248, P. 173956 - 173956

Published: Jan. 9, 2025

Language: Английский

Citations

0
Expression pattern of Arc in the hippocampus of a rat model of epilepsy and depression comorbidity DOI Creative Commons
Shiqian Yu, Hu Tuo, Baozhen Yao

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 223, P. 111267 - 111267

Published: Feb. 27, 2025

Language: Английский

Citations

0
Development of NIR photocleavable nanoparticles with BDNF for vestibular neuron regeneration DOI Creative Commons
Celine Abueva,

Sung Ryeong Yoon,

Nathaniel T. Carpena

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 13, 2025

Among nanoparticle platforms, light or photoresponsive nanoparticles have emerged as a promising drug delivery strategy with spatiotemporal control while minimizing off-target effects. The characteristic absorption spectrum of the moiety dictates wavelength needed to activate bond cleavage. However, low tissue penetration depth limit and short-wavelength ultraviolet (UV) cellular toxicity are considered disadvantageous. This study developed vestibular ganglion neuron organoid model for vestibulopathy. UV near-infrared (NIR) radiation targeted inner ear neural cells, followed by evaluation. A significantly smaller NIR was confirmed. photocleavage release brain-derived neurotrophic factor (BDNF) used applying wavelength. results indicate that polyethylene glycol octamethylene diamine derivative conjugated leucomethylene blue an ethanolamine linker can be effectively disassembled BDNF when using 808 nm laser trigger. findings cytotoxicity assay suggest photocleavable (PCNs) irradiation safe biocompatible human-derived progenitor types cells. Phototriggered supported growth differentiation human cells in culture. In addition, vestibulopathy exhibited significant regenerative effect. harnesses full potential PCNs treat neuropathies.

Language: Английский

Citations

0
Neuroprotection in pentylenetetrazol kindling rat model: A synergistic approach with eugenol and photobiomodulation DOI
Haitham S. Mohammed, Dalia Ahmed, Yasser A. Khadrawy

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149645 - 149645

Published: April 1, 2025

Language: Английский

Citations

0
Photobiomodulation effects on cognitive function — a systematic review and meta-analysis of randomized controlled trials DOI
Ziman Zhu, Rong Zhang,

Yijia Chi

et al.

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: May 21, 2025

Language: Английский

Citations

0