Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105822 - 105822
Published: Dec. 1, 2024
Language: Английский
Food Research International, Journal Year: 2025, Volume and Issue: 203, P. 115766 - 115766
Published: Jan. 23, 2025
Language: Английский
Citations
2
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Oct. 1, 2024
The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, be converted by microorganisms via indole pathway such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic (IPA), Indole Acetic (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that play key roles progression, they used adjuvant regimens for immunotherapy or chemotherapy. Here, we summarize recent findings on common microbial provide review mechanisms different microenvironment. We further discuss limitations current metabolite research future possibilities. It is expected will new strategies clinical therapy.
Language: Английский
Citations
9
Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)
Published: Jan. 1, 2025
ABSTRACT The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which primarily attributed interaction with iron in mitochondria, leading lipid peroxidation and myocardial ferroptosis. This study aimed investigate the role gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, ferroptosis were assessed vivo. cardioprotective effects mechanisms ILA explored using multi‐omics approaches, including single‐nucleus RNA sequencing (snRNA‐seq) bulk RNA‐seq, further validated Nrf2 knockout mice. findings revealed that DOX treatment disrupted microbiota, significantly reducing levels tryptophan metabolite ILA. In DIC models, supplementation markedly improved cardiac reduced collagen deposition, mitigated atrophy. snRNA‐seq analyses indicated played a crucial Experimental data demonstrated decreased both mice DOX‐treated H9C2 cells, evidenced by restoration GPX4 SLC7A11 reduction ACSL4. Mechanistically, functions as ligand for aryl hydrocarbon receptor (AhR), upregulation expression. protective against abolished silencing AhR. Moreover, beneficial on eliminated Nrf2‐deficient conclusion, exerts therapeutic inhibiting through activation AhR/Nrf2 signalling pathway. Identifying microbial could offer viable strategies DIC.
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
This study investigates the protective effects of lactic acid, a metabolite Bifidobacterium, on non-alcoholic fatty liver disease (NAFLD) induced by high-sugar, high-fat diet (HFD) in mice, context gut-liver axis. A NAFLD mouse model was established using HFD, and different intervention groups were set up to Bifidobacterium its acid. The included control group, treatment Glyceraldehyde-3-P (G-3P) co-treatment NOD-like receptor family pyrin domain containing 3 (NLRP3) overexpression group. evaluation function lipid metabolism conducted liver-to-body weight ratio, histological staining, biochemical assays. Enzyme-linked immunosorbent assay (ELISA) performed measure inflammatory cytokines, western blotting used analyze expression NLRP3 inflammasome autophagy-related molecules. In vitro, an cell oleic with cells treated acid assess droplet accumulation inflammation. vivo findings indicated that, comparison CBX group (Control without antibiotic treatment), NAFLD/CBX (NAFLD administration) NAFLD/ABX exhibited increased higher accumulation, aggravated histopathological damage, elevated levels AST (Aspartate Aminotransferase), ALT (Alanine TC (Total Cholesterol), TG (Triglycerides), LDL-C (Low-Density Lipoprotein IL-6 (Interleukin-6), TNF-α (Tumor Necrosis Factor-alpha), IL-1β (Interleukin-1 beta), NLRP3-related molecules, while HDL-C (High-Density Cholesterol) significantly decreased. Intervention reversed these adverse changes. Further addition G-3P led more pronounced improvement symptoms, weakened Bifidobacterium. vitro results that Ole heightened inflammasome-related molecules relative Treatment effectively changes; however, effect overexpression. Lactic can alleviate disorders through inhibition inflammation mediated regulation autophagy process.
Language: Английский
Citations
0
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Feb. 13, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101601 - 101601
Published: Feb. 20, 2025
Over the last two decades, molecular biology advances have revealed gut microbiota's active and crucial role in colorectal cancer (CRC) pathogenesis its dysregulation during tumorigenesis. This understanding has underscored urgency of exploring novel therapeutic approaches to address challenges posed by CRC. Among these approaches, nanosynergistic therapies, with their potential modulate microbiota, increase drug bioavailability stability, reduce side effects, emerged as a promising avenue. Furthermore, efficacy nanotechnology-based can be enhanced combining them different methods, including chemotherapy, radiotherapy, immunotherapy, photothermal therapy, sonodynamic therapy. Herein, recent progress nano synergistic therapy been reviewed, focusing on synergy between microbiota nanotechnology CRC treatment. Additionally, diverse applications nanoparticles analyzed provide innovative ideas effective solutions for developing highly treatment strategies.
Language: Английский
Citations
0
mSystems, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
ABSTRACT Colon cancer (CC) is one of the most common cancers globally, which associated with gut microbiota intimately. In current research, exploring complex interaction between microbiomes and CC a hotspot. However, information on in previous studies based fecal, does not fully display microbial environment CC. Herein, we collected mucosal tissue samples from both tumor normal regions 19 patients clarified composition by 16S rRNA metagenomic sequencing. Additionally, RNA-Seq was also conducted to identify different expression genes samples. We revealed significantly community structures profiles Depending correlation analysis, demonstrated that 1,472 were correlated microbiota. Our study reveals significant enrichment Campylobacter jejuni mucosa CC, correlates bile secretion. observe negative C. immune cells CD4+ Tem mast cells. Finally, discovered metabolic bacterial endosymbiont Bathymodiolus sp., Bacillus wiedmannii , Mycobacterium tuberculosis had survival value for ignored research. Overall, our expands understanding interplay provides new targets treatment IMPORTANCE This contributes colon (CC). By examining rather than solely relying fecal samples, have uncovered previously unknown aspects CC-associated findings reveal distinct gene progression. Notably, mucosa, linked secretion, underscores potential mechanisms pathogenesis. observed correlations taxa cell populations offer avenues immunotherapy research Importantly, this introduces implications expanding therapeutic beyond conventional strategies. elucidating these correlations, only uncovering role but establishes foundation mechanistic cancer, emphasizing broader impact biology.
Language: Английский
Citations
0
Annals of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Background The Bifidobacterium genus is a prominent bacterial population in the gastrointestinal tract. Previous findings suggest that linked to tumor suppression mouse models of melanoma. Additionally, when combined with programmed death-ligand 1 (PD-L1) antibody, it can enhance anti-tumor treatment by increasing tumor-specific T-cell responses and promoting infiltration antigen-specific T cells into tumors. However, there lack studies on esophageal squamous cell carcinoma (ESCC). This study aimed investigate potential impact this cancer type. Methods We examined 213 samples from ESCC patients who underwent resection. presence was confirmed using quantitative polymerase chain reaction fluorescent situ hybridization (FISH). Patient overall survival (OS) analyzed positivity. Tumor-infiltrating lymphocytes (TILs) were evaluated via hematoxylin eosin stains, immunohistochemistry used assess death-1 (PD-1), PD-L1, cluster differentiation 8 (CD8), forkhead box P3 (FOXP3) expression. Nutritional status computed tomography scans. Results positivity showed no correlation patient OS or TIL levels; however, normal tissue associated lower FOXP3 levels, suggesting role upregulating immune responses. Patients present peritumor exhibited better skeletal muscle area volume. Conversely, poorer prognostic nutrition index values, likely due decreased albumin levels. Conclusion induce upregulated response more prevalent cases good nutritional status.
Language: Английский
Citations
0
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123557 - 123557
Published: March 1, 2025
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 757 - 757
Published: March 27, 2025
The normal development and growth of bones are critical for poultry health. With the rapid increase in rates achieved over last few decades, juvenile meat-type exhibit a high incidence leg weakness lameness. These issues significant contributors to poor animal welfare substantial economic losses. Understanding potential etiology bone problems will aid developing treatments diseases. gut microbiota represents largest micro-ecosystem animals is closely related many metabolic disorders, including disease. It achieves this by secreting secondary metabolites coordinating with various tissues organs through circulatory system, which leads concept gut–X axis. Given its importance, modulating influence axis presents new opportunities understanding innovative therapeutic approaches In light extensive literature on topic, review focuses effects density strength poultry, both directly indirectly, regulation Our aim provide scientific insights into health faced poultry.
Language: Английский
Citations
0