An inulin-type fructan CP-A from Codonopsis pilosula combined with 5-Fluorouracil alleviates colitis-associated tumorigenesis via inhibition of EGFR/AKT/ERK signaling pathway and regulation of intestinal flora

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142655 - 142655

Published: March 1, 2025

Language: Английский

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Fusobacterium nucleatum Derived 3-Indolepropionic acid Promotes Colorectal Cancer Progression via Aryl Hydrocarbon Receptor Activation in Macrophages

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111495 - 111495

Published: March 1, 2025

Language: Английский

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Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(4), P. e011155 - e011155

Published: April 1, 2025

Background Gut microbiota can significantly alter the risk or progression of cancer by maintaining gut immune system homeostasis. However, exact mechanism which and its metabolites influence colorectal tumorigenesis is unclear. Methods The roles tryptophan metabolite indole-3-acetic acid (IAA) in inflammation tumor development were investigated dextran sodium sulfate (DSS) azoxymethane (AOM)-DSS mouse models with without IAA supplementation Lactobacillus reuteri -produced IAA. Pregnane X receptor (PXR) knockout (KO) mice aryl hydrocarbon KO used to explore regulates interleukin (IL)-35 expression. IL-35 + cells stimulated vitro analyzed flow cytometry. Additionally, liquid chromatography-mass spectrometry. Results We found that IAA, a produced L. , inhibit colitis inducing expression immunosuppressant cells. HuREG3α IECtg had high levels intestinal microbiota-derived these resistant AOM-DSS-induced cancer. Patients also low peripheral blood Further studies revealed IAA-producing alleviated symptoms inhibited colon tumors macrophages, T cells, B produce IL-35. Finally, PXR completely abolished effects on Conclusion demonstrate improve precancerous inflammatory environment through IL-35, thereby inhibiting tumorigenesis, suggesting may be preventive factor for colitis-related cancers.

Language: Английский

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Buqi-Huoxue-Tongnao decoction drives gut microbiota-derived indole lactic acid to attenuate ischemic stroke via the gut-brain axis

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 15, 2024

Language: Английский

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Mesoporous polydopamine (MPDA)-based drug delivery system for oral chemo-photothermal combinational therapy of orthotopic colon cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136618 - 136618

Published: Oct. 16, 2024

Language: Английский

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Indole Lactic Acid in Plasma and Urine: A Potential Biomarker for Chronic Kidney Disease and Inflammatory

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4105 - 4116

Published: June 1, 2024

Purpose: We aimed to explore changes in plasma and urine indole lactic acid (ILA) levels the relationship between inflammation ILA chronic kidney disease (CKD) patients healthy people. Patients Methods: Forty-seven CKD 30 individuals were included this study. One-way ANOVA was used for variables with normal distribution homogeneous variance. A rank-sum test performed non-normally distributed variables. Correlation analyses using Pearson's or Spearman correlation analyses. Independent analyzed ordinal binary logistic regressions. Receiver operating characteristic (ROC) curve used. Results: Plasma positively correlated (r = 0.51, P < 0.01). BMI, age, creatinine, BUN, triglycerides, uric negatively hemoglobin levels. Urine albumin Ordered regression analysis showed that significantly (OR=4.49, 0.01), urinary (OR=2.14, urea (OR=1.43, 0.01) (OR=0.95, related. ROC curves indicated reliable predictors of CKD. plasma, (OR=5.92, 0.01; OR=2.79, Hs-CRP (OR=2.45, Conclusion: can potentially be as biomarkers inflammatory status. Keywords: predictor, metabolomics, tryptophan metabolism,

Language: Английский

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Characterization of Eurotium cristatum Fermented Thinned Young Apple and Mechanisms Underlying Its Alleviating Impacts on Experimental Colitis

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(29), P. 16221 - 16236

Published: July 12, 2024

A hundred million tons of young apples are thinned and discarded in the orchard per year, aiming to increase yield quality apples. We fermented using a potential probiotic fungus,

Language: Английский

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Succession of the multi-site microbiome along pancreatic ductal adenocarcinoma tumorigenesis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

Background To investigate microbial characteristics across multibody sites from chronic pancreatitis (CP), through pancreatic benign tumors, to ductal adenocarcinoma (PDAC) at different stages. Methods 16S ribosomal RNA (rRNA) amplicon sequencing was conducted on saliva, duodenal fluid, and tissue obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of patients with CP, PDAC in stage I/II, III, IV. The neutral community model (NCM) assessed the assembly contribution MaAslin2 identified differential microbes. Results From CP IV patients, there a marked surge influence salivary microbiota constitution communities. Our observations revealed successive alteration species various bodily during tumorigenesis. Notably, Porphyromonas gingivalis , Treponema denticola Peptoanaerobacter stomatis Propionibacterium acidifaciens endodontalis Filifactor alocis etc., sequentially increased along progression tissue, whereas bacteria commonly used as probiotics Bifidobacterium breve Lactiplantibacillus plantarum declined. Furthermore, escalating trends tumorigenesis were mirrored fluid saliva. which intensified also found be enriched saliva short-term survival (STS) compared those long-term (LTS). Conclusions Salivary microorganisms prominent factors shaping landscape context. Further exploration these entities is imperative unravel their specific roles pathogenesis, potentially yielding insights for future therapeutic strategies.

Language: Английский

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Gut microbiota in cancer initiation, development and therapy

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Language: Английский

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From Biofilm to Breath: The Role of Lacticaseibacillus paracasei ET-22 Postbiotics in Combating Oral Malodor

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Previous studies demonstrated that sufferers with halitosis can be significantly improved

Language: Английский

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