Vigor King mitigates spermatogenic disorders caused by environmental estrogen zearalenone exposure DOI Creative Commons
Ning Zuo, Rui Wang,

Wen Meng Bian

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116757 - 116757

Published: July 23, 2024

Zearalenone (ZEN) has been shown to cause reproductive damage by inducing oxidative stress. Astaxanthin and L-carnitine are widely used alleviate stress promote sperm maturation. However, it remains uncertain whether they effective in mitigating spermatogenesis disorders induced ZEN. This study aimed investigate the therapeutic efficacy potential mechanisms of Vigor King (Vig), a compound preparation primarily consisting astaxanthin L-carnitine, alleviating ZEN-induced disorders. In experiment, mice received continuous oral gavage ZEN (80 μg/kg) for 35 days, accompanied rescue strategy with Vig (200 mg/kg). The results showed that effectively reduced negative impact on semen quality improved structural functional abnormalities seminiferous epithelium caused Additionally, accumulation reactive oxygen species (ROS), DNA double-strand breaks, apoptosis, autophagy were all significantly ameliorated. Intriguingly, GSK3β-dependent BTRC-NRF2 signaling pathway was found play an important role this process. Furthermore, testing offspring indicated could extend its protective effects next generation, combating transgenerational toxic summary, our research suggests supplementation holds considerable promise zearalenone.

Language: Английский

Lactylation in cancer: metabolic mechanism and therapeutic strategies DOI Creative Commons
Ying Sui, Ziyang Shen, Zhenling Wang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 20, 2025

Recent progress in cancer metabolism research has identified lactylation as a critical post-translational modification influencing tumor development and progression. The process relies on lactate accumulation the activation of lactate-sensitive acyltransferases. Beyond its role epigenetic regulation, emerged significant factor evolution, offering fresh opportunities for developing targeted therapies that transcend traditional approaches. This review explores growing importance biology highlights potential advancing diagnostic tools therapeutic strategies.

Language: Английский

Citations

1
Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells DOI Creative Commons
Xudong Zhang, Jian‐Jun Sun,

Xinmei Zheng

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103312 - 103312

Published: Aug. 17, 2024

Strong evidence indicates that environmental stressors are the risk factors for male testosterone deficiency (TD). However, mechanisms of stress-induced TD remain unclear. Based on our all-cause reproductive cohort, we found serum ferrous iron (Fe

Language: Английский

Citations

7
Ferroptosis: a novel mechanism of cell death in ophthalmic conditions DOI Creative Commons
Yaqi Yang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

Citations

5
Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and experimentation in vivo DOI Creative Commons

Yanggang Hong,

Qichao Yuan,

Yi Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117878 - 117878

Published: Feb. 1, 2025

Environmental pollutants, including chemical contaminants, heavy metals, and pesticides, have been linked to adverse effects on male reproductive health, particularly sperm quality. Non-obstructive azoospermia (NOA) is a severe form of infertility caused by intrinsic testicular dysfunction, leading complete absence in the ejaculate. Busulfan, an alkylating chemotherapeutic agent widely used treat chronic myelogenous leukemia, known induce NOA through its toxic spermatogonial stem cells (SSCs). This study aimed identify key molecular targets pathways disrupted busulfan environment. By integrating docking, single-cell RNA sequencing, vivo experimentation, identified POLE LRAT as critical proteins. These proteins were shown interact strongly with busulfan, genomic instability increased germ cell apoptosis during spermatogenesis. Additionally, immune landscape NOA-affected testes revealed significant changes infiltration, potentially worsening condition. findings offer new insights into mechanisms busulfan-induced suggest potential therapeutic for preserving fertility chemotherapy patients. research advances understanding chemotherapy-induced toxicity emphasizes need strategies reduce negative fertility.

Language: Английский

Citations

0
TF and TFRC regulate ferroptosis in swine testicular cells through the JNK signaling pathway DOI

Yuanjie Zhao,

Ge Qin,

Weimin Fan

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142369 - 142369

Published: March 1, 2025

Language: Английский

Citations

0
Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications DOI
Ayodeji Folorunsho Ajayi, Mega O. Oyovwi,

Goodness Olusayo Olatinwo

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Aug. 1, 2024

Language: Английский

Citations

2
Fluorene-9-bisphenol impaired male fertility through disrupting the testicular function and local microenvironment DOI Creative Commons
Danni Jiang, Yang Yang,

Xiaojuan Han

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116880 - 116880

Published: Aug. 13, 2024

Past studies have observed that BHPF induces multi-organ toxicity, however, whether it damage to male reproductive system and the specific mechanism remains unclear. In present study, mice were given 0, 2, 10 or 50 mg/kg/day of by gavage for 35 days observe its effect on organ sperm quality. The results indicated decreased count motility in a dose-dependent manner. Besides, our demonstrated triggered proliferation inhibition cell death germ cells vivo vitro. Also, reduced expression function markers cells, Sertoli Leydig indicating testis cells. Simultaneously, testicular microenvironment was found be altered BHPF, as presented with declined testosterone level local regulators. Overall, findings detrimental effects mice, suggesting disturbance underlying damage.

Language: Английский

Citations

1
Vigor King mitigates spermatogenic disorders caused by environmental estrogen zearalenone exposure DOI Creative Commons
Ning Zuo, Rui Wang,

Wen Meng Bian

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116757 - 116757

Published: July 23, 2024

Zearalenone (ZEN) has been shown to cause reproductive damage by inducing oxidative stress. Astaxanthin and L-carnitine are widely used alleviate stress promote sperm maturation. However, it remains uncertain whether they effective in mitigating spermatogenesis disorders induced ZEN. This study aimed investigate the therapeutic efficacy potential mechanisms of Vigor King (Vig), a compound preparation primarily consisting astaxanthin L-carnitine, alleviating ZEN-induced disorders. In experiment, mice received continuous oral gavage ZEN (80 μg/kg) for 35 days, accompanied rescue strategy with Vig (200 mg/kg). The results showed that effectively reduced negative impact on semen quality improved structural functional abnormalities seminiferous epithelium caused Additionally, accumulation reactive oxygen species (ROS), DNA double-strand breaks, apoptosis, autophagy were all significantly ameliorated. Intriguingly, GSK3β-dependent BTRC-NRF2 signaling pathway was found play an important role this process. Furthermore, testing offspring indicated could extend its protective effects next generation, combating transgenerational toxic summary, our research suggests supplementation holds considerable promise zearalenone.

Language: Английский

Citations

0