Change in the Clinical Picture of Hospitalized Patients with COVID-19 between the Early and Late Period of Dominance of the Omicron SARS-CoV-2 Variant

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(17), P. 5572 - 5572

Published: Aug. 26, 2023

This study aimed to compare the clinical picture of COVID-19 in initial and later period Omicron dominance identify populations still at risk. A retrospective comparison data 965 patients hospitalized during early Omicron's (EO, January-June 2022) with 897 from a (LO, July 2022-April 2023) SARSTer database was performed. Patients LO, compared EO, were older, had better condition on admission, lower need for oxygen mechanical ventilation, less frequent lung involvement imaging, showed much faster improvement. Moreover, overall mortality EO 14%, higher than that LO-9%. Despite milder course disease, exceeding 15% similar both groups among involvement. The accumulation risk factors such as an age 60+, comorbidities, involvement, saturation <90% resulted constant 98% patients, 8% 30% rate LO period. Multiple logistic regression revealed odds death phase. infections caused by currently dominant subvariants, prophylaxis is necessary people over 60 years age, especially those case pneumonia respiratory failure.

Language: Английский

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Inflammatory Response in COVID-19 Depending on the Severity of the Disease and the Vaccination Status

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8550 - 8550

Published: May 10, 2023

The aim of this study was to analyze the serum concentration interleukin-6 (IL-6), C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), ferritin, and procalcitonin in COVID-19 patients with different forms disease. We performed a prospective cohort on 137 consecutive patients, divided into four groups according severity disease as follows: 30 mild form group, 49 moderate 28 severe critical group. tested parameters were correlated severity. Significant differences registered between depending vaccination status, LDH concentrations virus variant, IL-6, CRP, ferritin status gender. ROC analysis revealed that D-dimer best predicted variant. Our findings confirmed interdependence relationships observed inflammation markers relation clinical COVID-19, all biomarkers increasing COVID-19. LDH, increased forms. These inflammatory lower Omicron-infected patients. unvaccinated developed more compared vaccinated ones, higher proportion them needed hospitalization. could predict while

Language: Английский

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The Course of COVID-19 and Long COVID: Identifying Risk Factors among Patients Suffering from the Disease before and during the Omicron-Dominant Period

Pathogens, Journal Year: 2024, Volume and Issue: 13(3), P. 267 - 267

Published: March 20, 2024

SARS-CoV-2 has acquired many mutations that influence the severity of COVID-19's course or risk developing long COVID. In 2022, dominant variant was Omicron. This study aimed to compare COVID-19 in periods before and during dominance Omicron variant. Risk factors for COVID were also assessed. based on stationary visits patients after follow-up assessments 3 months. Clinical symptoms, comorbidities, vaccination status evaluated 1967 patients. Of analyzed group, 1308 (66.5%) affected by period dominance. The prevalence significantly lower among group (47.7% vs. 66.9%,

Language: Английский

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Lessons we learned during the past four challenging years in the COVID-19 era: pharmacotherapy, long COVID complications, and vaccine development

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 26, 2024

About four years have passed since the detection of first cases COVID-19 in China. During this lethal pandemic, millions people lost their lives around world. Since waves infection, various pharmacotherapeutic agents been examined management COVID-19. Despite all these efforts pharmacotherapy, drug repurposing, and design development new drugs, multiple organ involvement complications occurred during Some became chronic long-lasting which led to "long COVID" syndrome appearance. Therefore, best way eradicate pandemic is prophylaxis through mass vaccination. In regard, vaccine platforms including inactivated vaccines, nucleic acid-based vaccines (mRNA DNA vaccines), adenovirus-vectored protein-based subunit designed developed prevent or reduce hospitalization, mortality rates. focused review, at first, most commonly reported clinical presentations summarized. addition, different therapeutic regimens latest status listed. Furthermore, related signs, symptoms, mentioned. At end, effectiveness available with against early SARS-CoV-2 variants currently circulating interest (VOI) necessity booster shots summarized discussed more detail.

Language: Английский

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Clinical characteristics of the severe acute respiratory syndrome coronavirus 2 omicron variant compared with the delta variant: a retrospective case-control study of 318 outpatients from a single sight institute in Japan

PeerJ, Journal Year: 2022, Volume and Issue: 10, P. e13762 - e13762

Published: Aug. 2, 2022

Background Clinical characteristics, including laboratory parameters, of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant have been limited. Methods This retrospective case-control study was conducted in a single hospital. Patients with disease 2019 (COVID-19) who visited Asahikawa City Hospital outpatient department as new patients and underwent blood tests were included this study. We analyzed data from January 2022 to April during phase 2021 October Delta phase. treated at other hospitals after visiting our hospital excluded. All performed before treatment for COVID-19 initiated. Demographic information, data, clinical courses extracted electronic medical records. matched two groups by age comorbidities compared their characteristics. also factors associated pneumonia Results A total 151 167 delta The mean age, rate comorbidities, vaccination significantly higher group. number or those requiring oxygen, admissions, both lower Lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, aspartate aminotransferase (AST), neutrophil-to-lymphocyte ratio (NLR) levels Compared mild symptom group, older body mass index (BMI), non-vaccination, LDH, CRP Conclusion is reduction hospitalization risk real-life setting. In variant, related high-risk factors, such LDH levels, no vaccination.

Language: Английский

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