Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research DOI Creative Commons
Thijs J. Walbeek, E. Harrison, Michael R. Gorman

et al.

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 1, 2021

In this review, we discuss the remarkable potency and potential applications of a form light that is often overlooked in circadian context: naturalistic levels dim at night (nLAN), equivalent to intensities produced by moon stars. It assumed such low do not produce responses typically associated with brighter levels. A solid understanding impacts very complicated further broad use somewhat ambiguous term “dim light,” which has been used describe ranging seven orders magnitude. Here, lay out argument nLAN exerts potent effects on numerous mammalian species, given conservation anatomy function, efficacy range humans warrants investigation. We also provide recommendations for field chronobiological research, including minimum requirements measurement reporting light, standardization terminology (specifically as it pertains “dim” light), ideas reconsidering old data designing new studies.

Language: Английский

Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice DOI Creative Commons
Raniki Kumari, Raluca Paşcalău, Hui Wang

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(2), P. 113674 - 113674

Published: Jan. 21, 2024

Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and anxiolytic agent reducing energy expenditure. NPY also co-expressed with norepinephrine (NE) sympathetic neurons. Although generally considered to modulate noradrenergic responses, specific roles autonomic physiology remain under-appreciated. Here, we show that sympathetic-derived essential metabolic cardiovascular regulation mice. NE are 90% of prevertebral neurons only 43% paravertebral NPY-expressing primarily innervate blood vessels peripheral organs. Sympathetic-specific deletion elicits pronounced defects mice, including reductions insulin secretion, glucose tolerance, cold pupil size elevated heart rate, while notably, however, basal pressure was unchanged. These findings provide insight into target tissue-specific functions derived from imply potential involvement diseases.

Language: Английский

Citations

5
Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells DOI Creative Commons
Cheng Qian, Ying Xin, Cheng Qi

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 11, 2024

Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how intercellular communication contributes to retinal ganglion cell (RGC) following optic nerve crush based single-cell RNA-seq analysis. We observed transcriptomic changes in cells response injury, with astrocytes and Müller glia having most interactions RGCs. By comparing RGC subclasses characterized by distinct resilience death, we found that high-survival RGCs tend more ligand-receptor neighboring cells. identified 47 stronger RGCs, likely mediating neuroprotective effects. validated one target, μ-opioid receptor (Oprm1), be three injury models. Although endogenous Oprm1 is preferentially expressed intrinsically photosensitive its effect can transferred other pan-RGC overexpression Oprm1. Lastly, manipulating activity improved visual functions mice.

Language: Английский

Citations

5
M1 Intrinsically Photosensitive Retinal Ganglion Cells Integrate Rod and Melanopsin Inputs to Signal in Low Light DOI Creative Commons

Seul Ki Lee,

Takuma Sonoda, Tiffany M. Schmidt

et al.

Cell Reports, Journal Year: 2019, Volume and Issue: 29(11), P. 3349 - 3355.e2

Published: Dec. 1, 2019

Light influences various behaviors and physiological processes that occur outside of our conscious perception, including circadian photoentrainment, sleep, even learning mood. The M1, melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) relay a combination rod/cone melanopsin signals to drive these functions. However, little is known about how M1 ipRGCs integrate in low light. We measure the dim light response find they exhibit wide spectrum responses dim, scotopic stimulation are driven by rod pathway input phototransduction. presence correlates with larger more complex dendritic arbors. Collectively, results show variability surprising contribution at very

Language: Английский

Citations

42
A head mounted device stimulator for optogenetic retinal prosthesis DOI Creative Commons
Ahmed Soltan, John M. Barrett,

Pleun Maaskant

et al.

Journal of Neural Engineering, Journal Year: 2018, Volume and Issue: 15(6), P. 065002 - 065002

Published: Aug. 29, 2018

Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics stimulate an optogenetic retina. Hence, we aim introduce a non-invasive approach restore vision for people conditions such as retinitis pigmentosa where there remaining viable communication link between the retina and visual cortex. Approach. We design implement headset using high-density µLED matrix, Raspberry Pi, microcontroller from NXP lens. Then, test platform developed evaluate performance of optical system. Furthermore, image simplification algorithms are simplify scene sent Moreover, in vivo evaluation genetically modified response at different light intensity discussed prove reliability proposed Main results. keeping regulatory guidance, need limit their luminance 90 kcd m−2. system 5.75% efficiency which allows 0.16 mW mm−2 irradiance on within but capable average peak 1.35 mm−2. As this lower than commonly accepted threshold channelrhodopsin-2, efficacy through model eye onto biological Significance. fully functional 8100-pixel including software/hardware operate standard consumer battery periods exceeding 24 h recharge cycle. The delivering enough cells also amount below regulation safety.

Language: Английский

Citations

40
Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research DOI Creative Commons
Thijs J. Walbeek, E. Harrison, Michael R. Gorman

et al.

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: Feb. 1, 2021

In this review, we discuss the remarkable potency and potential applications of a form light that is often overlooked in circadian context: naturalistic levels dim at night (nLAN), equivalent to intensities produced by moon stars. It assumed such low do not produce responses typically associated with brighter levels. A solid understanding impacts very complicated further broad use somewhat ambiguous term “dim light,” which has been used describe ranging seven orders magnitude. Here, lay out argument nLAN exerts potent effects on numerous mammalian species, given conservation anatomy function, efficacy range humans warrants investigation. We also provide recommendations for field chronobiological research, including minimum requirements measurement reporting light, standardization terminology (specifically as it pertains “dim” light), ideas reconsidering old data designing new studies.

Language: Английский

Citations

28