
Neuron, Journal Year: 2019, Volume and Issue: 104(5), P. 987 - 999.e4
Published: Oct. 15, 2019
Language: Английский
Neuron, Journal Year: 2019, Volume and Issue: 104(5), P. 987 - 999.e4
Published: Oct. 15, 2019
Language: Английский
Annual Review of Neuroscience, Journal Year: 2017, Volume and Issue: 40(1), P. 373 - 394
Published: April 25, 2017
Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine make this calculation. Here we review studies that tackle problem from a diverse set approaches, anatomy to electrophysiology computational modeling behavior. Several patterns emerge synthesis: themselves calculate rather than inherit passively upstream regions; they combine multiple separate redundant inputs, which are interconnected in dense recurrent network; despite complexity output is remarkably homogeneous robust. The more study simple arithmetic computation, knottier appears be, suggesting daunting (but stimulating) path ahead for neuroscience generally.
Language: Английский
Citations
408Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(10), P. 1421 - 1430
Published: Aug. 21, 2018
Language: Английский
Citations
346eLife, Journal Year: 2017, Volume and Issue: 6
Published: March 21, 2017
Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role to promote flexible adaptation changes the causal structure of environment, through behavioral inhibition enhanced plasticity. We used long-term photometric recordings mice study population dorsal raphe serotonin neurons, whose activity we could link normal reversal learning using pharmacogenetics. found these neurons are activated by both positive negative prediction errors, thus report signals similar those proposed conditions uncertainty. Furthermore, comparing cue responses dopamine differences rates explain importance inhibiting perseverative responding. Our findings show how patterns support cognitive flexibility, suggest revised model dopamine-serotonin opponency with potential clinical implications.
Language: Английский
Citations
226Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(11), P. 703 - 714
Published: Sept. 30, 2019
Language: Английский
Citations
205eLife, Journal Year: 2017, Volume and Issue: 6
Published: May 19, 2017
The computational principles by which the brain creates a painful experience from nociception are still unknown. Classic theories suggest that cortical regions either reflect stimulus intensity or additive effects of and expectations, respectively. By contrast, predictive coding provide unified framework explaining how perception is shaped integration beliefs about world with mismatches resulting comparison these against sensory input. Using functional magnetic resonance imaging during probabilistic heat pain paradigm, we investigated computations underlie perception. Skin conductance, pupil dilation, anterior insula responses to cued stimuli strictly followed response patterns hypothesized model, whereas posterior encoded intensity. This novel dissociation processing within together previously observed alterations in chronic offer interpretation aberrant as disturbed weighting predictions prediction errors.
Language: Английский
Citations
175eLife, Journal Year: 2018, Volume and Issue: 7
Published: Nov. 13, 2018
Extinction of fear responses is critical for adaptive behavior and deficits in this form safety learning are hallmark anxiety disorders. However, the neuronal mechanisms that initiate extinction largely unknown. Here we show, using single-unit electrophysiology cell-type specific fiber photometry, dopamine neurons ventral tegmental area (VTA) activated by omission aversive unconditioned stimulus (US) during extinction. This signal occurred specifically beginning when US unexpected, correlated strongly with learning. Furthermore, temporally-specific optogenetic inhibition or excitation at time revealed both necessary for, sufficient to accelerate, normal These results identify a prediction error-like reveal crucial role DA
Language: Английский
Citations
174Frontiers in Psychology, Journal Year: 2019, Volume and Issue: 10
Published: April 24, 2019
Emotion plays a crucial role, both in general human experience and psychiatric illnesses. Despite the importance of emotion, relative lack objective methodologies to scientifically studying emotional phenomena limits our current understanding thereby calls for development novel methodologies, such us study illustrative animal models. Analysis Drosophila other insects has unlocked new opportunities elucidate behavioral phenotypes fundamentally phenomena. Here we propose an integrative model basic emotions based on observations this model. The are internal states that modulated by neuromodulators, these externally expressed as certain stereotypical behaviors, instinct, which is proposed ancient mechanisms survival. There four kinds emotions: happiness, sadness, fear anger, differentially associated with three core affects: reward (happiness), punishment (sadness), stress (fear anger). These affects analogous primary colors (red, yellow, blue) they combined various proportions result more complex "higher order" emotions, love aesthetic emotion. We refer called "Three Primary Color Model Basic Emotions".
Language: Английский
Citations
172Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(11), P. 1820 - 1833
Published: Oct. 14, 2019
Language: Английский
Citations
159Nature Neuroscience, Journal Year: 2021, Volume and Issue: 25(1), P. 86 - 97
Published: Dec. 2, 2021
Language: Английский
Citations
115Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(8), P. 1574 - 1586
Published: July 3, 2024
Language: Английский
Citations
34