A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 26, 2021

Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of

Language: Английский

---

Commensal bacteria and essential amino acids control food choice behavior and reproduction

PLoS Biology, Journal Year: 2017, Volume and Issue: 15(4), P. e2000862 - e2000862

Published: April 25, 2017

Choosing the right nutrients to consume is essential health and wellbeing across species. However, factors that influence these decisions are poorly understood. This particularly true for dietary proteins, which important determinants of lifespan reproduction. We show in Drosophila melanogaster, amino acids (eAAs) concerted action commensal bacteria Acetobacter pomorum Lactobacilli critical modulators food choice. Using a chemically defined diet, we absence any single eAA from diet sufficient elicit specific appetites acid (AA)-rich food. Furthermore, buffer animal lack eAAs: both increased yeast appetite decreased reproduction induced by deprivation rescued presence commensals. Surprisingly, effects do not seem be due changes AA titers, suggesting gut act through different mechanism change behavior Thus, eAAs potent feeding reproductive output. demonstrates how interaction with microbiome can shape behavioral life history traits.

Language: Английский

---

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(3), P. 610 - 621

Published: March 1, 2017

Language: Английский

---

Ethology as a physical science

Nature Physics, Journal Year: 2018, Volume and Issue: 14(7), P. 653 - 657

Published: April 9, 2018

Language: Английский

---

Wearable full-body motion tracking of activities of daily living predicts disease trajectory in Duchenne muscular dystrophy

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(1), P. 95 - 103

Published: Jan. 1, 2023

Artificial intelligence has the potential to revolutionize healthcare, yet clinical trials in neurological diseases continue rely on subjective, semiquantitative and motivation-dependent endpoints for drug development. To overcome this limitation, we collected a digital readout of whole-body movement behavior patients with Duchenne muscular dystrophy (DMD) (n = 21) age-matched controls 17). Movement was assessed while participant engaged everyday activities using 17-sensor bodysuit during three visits over course 12 months. We first defined new behavioral fingerprints capable distinguishing DMD from controls. Then, used machine learning algorithms that combined make cross-sectional longitudinal disease predictions, which outperformed predictions derived currently assessments. Finally, Bayesian optimization, constructed biomarker, termed KineDMD ethomic is daily-life data whose value progresses age an S-shaped sigmoid curve form. The biomarker developed study, readouts behavior, can predict progression potentially track response therapy.

Language: Английский

---

Idiothetic Path Integration in the Fruit Fly Drosophila melanogaster

Current Biology, Journal Year: 2017, Volume and Issue: 27(15), P. 2227 - 2238.e3

Published: July 20, 2017

Language: Английский

---

A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

Neuron, Journal Year: 2019, Volume and Issue: 104(3), P. 544 - 558.e6

Published: Aug. 27, 2019

In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion fear. How need motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that flies persistently track food odor increase their effort over repeated trials in absence reward suggesting dominates negative experience. We further tracking regulated by two mushroom body output neurons (MBONs) connecting MB lateral horn. These MBONs, together with dopaminergic Dop1R2 signaling, behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one acts as brake on feeding olfaction. Together, our data suggest function for internal state-dependent expression can be suppressed external inputs conveying competing drive.

Language: Английский

---

Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger

Science, Journal Year: 2017, Volume and Issue: 356(6337), P. 534 - 539

Published: May 4, 2017

The drive to eat protein is mediated by plastic changes in a dedicated neuronal circuit Drosophila .

Language: Английский

---

Neural basis of hunger-driven behaviour in Drosophila

Open Biology, Journal Year: 2019, Volume and Issue: 9(3)

Published: March 1, 2019

Hunger is a motivational state that drives eating and food-seeking behaviour. In psychological sense, hunger sets the goal guides an animal in pursuit of food. The biological basis underlying this purposive, goal-directed nature has been under intense investigation. With its rich behavioural repertoire genetically tractable nervous system, fruit fly Drosophila melanogaster emerged as excellent model system for studying neural hunger-driven Here, we review our current understanding how sensed, encoded translated into foraging feeding behaviours fly.

Language: Английский

---

A post-ingestive amino acid sensor promotes food consumption in Drosophila

Cell Research, Journal Year: 2018, Volume and Issue: 28(10), P. 1013 - 1025

Published: Sept. 12, 2018

Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective sources ensure dietary amino acid plays a critical role in homeostasis. By using quantitative feeding assay, we show that three acids, L-glutamate (L-Glu), L-alanine (L-Ala) L-aspartate (L-Asp), but not their D-enantiomers or other 17 natural L-amino acids combined, rapidly promote food consumption fruit fly Drosophila melanogaster. This feeding-promoting effect independent mating experience internal nutritional status. In vivo ex calcium imagings six brain neurons expressing diuretic hormone 44 (DH44) can be directly activated by these suggesting are an sensor. Genetic inactivation DH44+ abolishes increase induced whereas genetic activation sufficient to feeding, mediate consumption. Single-cell transcriptome analysis immunostaining reveal putative transporter, CG13248, enriched neurons. Knocking down CG13248 expression blocks eliminates responses acids. Therefore, data identify neuron as key sensor detect enhance via transporter CG13248. These results shed light on regulation homeostasis at organismal levels nervous system.

Language: Английский

---