A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 26, 2021

Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of

Language: Английский

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The insect central complex and the neural basis of navigational strategies

Journal of Experimental Biology, Journal Year: 2019, Volume and Issue: 222(Suppl_1)

Published: Feb. 6, 2019

ABSTRACT Oriented behaviour is present in almost all animals, indicating that it an ancient feature has emerged from animal brains hundreds of millions years ago. Although many complex navigation strategies have been described, each strategy can be broken down into a series elementary navigational decisions. In moment time, to compare its current heading with desired direction and compensate for any mismatch by producing steering response either the right or left. Different reflex-driven movements, target-directed not only initiated sensory input, but also takes account previous experience motivational state. Once decisions are chained together form one coherent strategies, pursue target, e.g. food source, nest entrance constant flight during migrations. Insects show great variety behaviours and, owing their small brains, pursuit neural circuits controlling made substantial progress over last years. A brain region as insects themselves, called central complex, likely centre brain. Research across species shown contains circuitry might comprise substrate this involved wide range other functions, we hypothesize Review role mediating animal's next move ancestral function, around which functions layered course evolution.

Language: Английский

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Principles of Insect Path Integration

Current Biology, Journal Year: 2018, Volume and Issue: 28(17), P. R1043 - R1058

Published: Sept. 1, 2018

Language: Английский

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Transforming representations of movement from body- to world-centric space

Nature, Journal Year: 2021, Volume and Issue: 601(7891), P. 98 - 104

Published: Dec. 15, 2021

Language: Английский

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Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Aug. 21, 2018

Odor attraction in walking Drosophila melanogaster is commonly used to relate neural function behavior, but the algorithms underlying are unclear. Here, we develop a high-throughput assay measure olfactory behavior response well-controlled sensory stimuli. We show that odor evokes two behaviors: an upwind run during (ON response), and local search at offset (OFF response). Wind orientation requires antennal mechanoreceptors, driven solely by odor. Using dynamic stimuli, dependence of these behaviors on intensity history. Based data, navigation model recapitulates flies our apparatus, generates realistic trajectories when turbulent boundary layer plume. The ability parse into quantifiable elementary sensori-motor transformations provides foundation for dissecting circuits govern behavior.

Language: Английский

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Unraveling the neural basis of insect navigation

Current Opinion in Insect Science, Journal Year: 2017, Volume and Issue: 24, P. 58 - 67

Published: Sept. 20, 2017

Language: Английский

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Neural basis of hunger-driven behaviour in Drosophila

Open Biology, Journal Year: 2019, Volume and Issue: 9(3)

Published: March 1, 2019

Hunger is a motivational state that drives eating and food-seeking behaviour. In psychological sense, hunger sets the goal guides an animal in pursuit of food. The biological basis underlying this purposive, goal-directed nature has been under intense investigation. With its rich behavioural repertoire genetically tractable nervous system, fruit fly Drosophila melanogaster emerged as excellent model system for studying neural hunger-driven Here, we review our current understanding how sensed, encoded translated into foraging feeding behaviours fly.

Language: Английский

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Mechanisms Underlying the Neural Computation of Head Direction

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 43(1), P. 31 - 54

Published: Dec. 24, 2019

Many animals use an internal sense of direction to guide their movements through the world. Neurons selective head are thought support this directional and have been found in a diverse range species, from insects primates, highlighting evolutionary importance. Across most head-direction networks share four key properties: unique representation at all times, persistent activity absence movement, integration angular velocity update representation, cues correct drift. The dynamics theorized network structures called ring attractors elegantly account for these properties, but relationship brain circuits is unclear. Here, we review experiments rodents flies that offer insights into potential neural implementations attractor networks. We suggest theory-guided search across model systems biological mechanisms enable such would uncover general principles underlying circuit function.

Language: Английский

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Multimodal interactions in insect navigation

Animal Cognition, Journal Year: 2020, Volume and Issue: 23(6), P. 1129 - 1141

Published: April 22, 2020

Abstract Animals travelling through the world receive input from multiple sensory modalities that could be important for guidance of their journeys. Given availability a rich array cues, idiothetic information to sky compasses and visual olfactory other cues (e.g. gustatory, magnetic, anemotactic or thermal) it is no surprise see multimodality in most aspects navigation. In this review, we present current knowledge multimodal cue use during orientation navigation insects. Multimodal adapted species’ ecology shapes behaviour both learning environmental when performing complex foraging The simultaneous beneficial because provides redundant navigational information, general, increases robustness, accuracy overall success. We examples sensorimotor behaviours mosquitoes flies as well large scale ants, bees insects migrate seasonally over distances, asking at each stage how are combined behaviourally what gain using different modalities.

Language: Английский

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Distinct activity-gated pathways mediate attraction and aversion to CO2 in Drosophila

Nature, Journal Year: 2018, Volume and Issue: 564(7736), P. 420 - 424

Published: Nov. 20, 2018

Language: Английский

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