Molecular Evolution of the Major Arthropod Chemoreceptor Gene Families

Annual Review of Entomology, Journal Year: 2018, Volume and Issue: 64(1), P. 227 - 242

Published: Oct. 12, 2018

The evolutionary origins of the three major families chemoreceptors in arthropods-the odorant receptor (OR), gustatory (GR), and ionotropic (IR) families-occurred at base Insecta, Animalia, Protostomia, respectively. Comparison family sizes across arthropods reveals a generally positive correlation with their widely disparate complexity chemical ecology. Closely related species reveal ongoing processes gene evolution, including duplication, divergence, pseudogenization, loss, that mediate these larger patterns. Sets paralogous receptors within selection on amino acids regions likely to contribute ligand binding specificity. Ligands many ORs some GRs IRs have been identified; however, identification for more is needed, as are structures OR/GR superfamily, improve our understanding molecular evolution ecologically important arthropods.

Language: Английский

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Aedes aegypti Mosquitoes Detect Acidic Volatiles Found in Human Odor Using the IR8a Pathway

Current Biology, Journal Year: 2019, Volume and Issue: 29(8), P. 1253 - 1262.e7

Published: March 28, 2019

Language: Английский

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Information flow, cell types and stereotypy in a full olfactory connectome

eLife, Journal Year: 2021, Volume and Issue: 10

Published: May 25, 2021

The

Language: Английский

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Functional properties of insect olfactory receptors: ionotropic receptors and odorant receptors

Cell and Tissue Research, Journal Year: 2021, Volume and Issue: 383(1), P. 7 - 19

Published: Jan. 1, 2021

Abstract The majority of insect olfactory receptors belong to two distinct protein families, the ionotropic (IRs), which are related glutamate receptor family, and odorant (ORs), evolved from gustatory family. Both types assemble heteromeric ligand-gated cation channels composed odor-specific proteins co-receptor proteins. We here present in short current view on evolution, function, regulation IRs ORs. Special attention is given how their functional properties can meet environmental ecological challenges an has face.

Language: Английский

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Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons

eLife, Journal Year: 2022, Volume and Issue: 11

Published: April 20, 2022

olfactory neurons have long been thought to express only one chemosensory receptor gene family. There are two main families in

Language: Английский

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Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites

Neuron, Journal Year: 2023, Volume and Issue: 111(6), P. 874 - 887.e8

Published: Jan. 13, 2023

Language: Английский

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Cross-modal sensory compensation increases mosquito attraction to humans

Science Advances, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

Sensory compensation occurs when loss of one sense leads to enhanced perception by another sense. We have identified a previously undescribed mechanism sensory in female Aedes aegypti mosquitoes. Odorant receptor co-receptor ( Orco ) mutants show attraction human skin temperature and increased heat-evoked neuronal activity foreleg neurons. Ir140 , foreleg-enriched member the ionotropic (IR) superfamily receptors, is up-regulated mutant legs. double do not heat seeking seen single mutants, suggesting that up-regulation key underlying mutants. Because expression sparse legs, this requires an indirect, long-range mechanism. Our findings highlight how mosquitoes, despite suffering olfactory loss, maintain overall effectiveness their host-seeking behavior up-regulating temperature, further enhancing status as most dangerous predator humans.

Language: Английский

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Multiple blood feeding bouts in mosquitoes allow for prolonged survival and are predicted to increase viral transmission during dry periods

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111760 - 111760

Published: Jan. 9, 2025

Dry conditions increase blood feeding in mosquitoes, but it is unknown if dehydration-induced bloodmeals are increased beyond what necessary for reproduction. In this study, we investigated the role of dehydration secondary behaviors mosquitoes. Following an initial bloodmeal, prolonged exposure to dry mosquitoes by nearly two-fold, and chronic allowed survive up 20 days without access water. Exposure desiccating following a bloodmeal resulted activity, decreased sleep levels, prompted return CO2 sensing before egg deposition. Increased higher survival during periods predicted pathogen transmission, allowing rapid rebound mosquito populations when favorable return. Overall, these results solidify our understanding how impact that contributes transmission dynamics.

Language: Английский

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Genome sequences of four Ixodes species expands understanding of tick evolution

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Language: Английский

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An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Oct. 8, 2018

Abstract Through analysis of the Drosophila ionotropic receptors (IRs), a family variant glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations diverse gustatory organs larvae and adults. We characterise IR56d, which defines two anatomically-distinct classes proboscis: one responds to carbonated solutions fatty acids while other represents subset sugar- acid-sensing cells. Mutational indicates together with broadly-expressed co-receptors IR25a IR76b, is essential for physiological responses carbonation acids, but not sugars. further demonstrate both promote IR56d-dependent attraction flies, through different behavioural outputs. Our work provides toolkit investigating taste functions IRs, these required sensing, illustrates how system uses combinatorial expression sensory molecules distinct neurons coordinate behaviour.

Language: Английский

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