Astrocyte and neuron cooperation in long-term depression DOI Creative Commons

Caitlin A. Durkee,

Paulo Kofuji, Marta Navarrete

et al.

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(10), P. 837 - 848

Published: July 30, 2021

Language: Английский

Versatile control of synaptic circuits by astrocytes: where, when and how? DOI
Glenn Dallérac, Jonathan Zapata, Nathalie Rouach

et al.

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(12), P. 729 - 743

Published: Nov. 6, 2018

Language: Английский

Citations

159

Astrocyte–Neuron Networks: A Multilane Highway of Signaling for Homeostatic Brain Function DOI Creative Commons
Sara Mederos, Candela González-Arias, Gertrudis Perea

et al.

Frontiers in Synaptic Neuroscience, Journal Year: 2018, Volume and Issue: 10

Published: Nov. 27, 2018

Research on glial cells over the past 30 years has confirmed critical role of astrocytes in pathophysiological brain states. However, most our knowledge about astrocyte physiology and interactions between neurons is based premises that constitute a homogeneous cell type, without considering particular properties circuits or nuclei which are located. Therefore, we argue more-sophisticated experiments required to elucidate specific features different regions, even within layers circuit. Thus, addition diverse mechanisms used by communicate with synaptic partners, it necessary take into account cellular heterogeneity likely contributes outcomes astrocyte-neuron signaling. In this review article, briefly summarize current data regarding anatomical, molecular functional communication, as well communication.

Language: Английский

Citations

136

Astrocytes modulate sensory-evoked neuronal network activity DOI Creative Commons
Justin Lines, E. Martin, Paulo Kofuji

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: July 23, 2020

While neurons principally mediate brain function, astrocytes are emerging as cells with important neuromodulatory actions in physiology. In addition to homeostatic roles, respond neurotransmitters calcium transients stimulating the release of gliotransmitters that regulate synaptic and neuronal functions. We investigated astrocyte-neuronal network interactions vivo by combining two-photon microscopy monitor astrocyte electrocorticogram record activity somatosensory cortex during sensory stimulation. found stimuli a stimulus-dependent manner. Sensory elicit surge gamma range (30-50 Hz) followed delayed dampens steady-state activity. This sensory-evoked increase is enhanced transgenic mice impaired signaling decreased pharmacogenetic stimulation astrocytes. Therefore, cortical inputs maximizing its dynamic range.

Language: Английский

Citations

135

GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors DOI
Sara Mederos, Cristina Sánchez‐Puelles, Julio Esparza

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 24(1), P. 82 - 92

Published: Dec. 7, 2020

Language: Английский

Citations

128

Glia as sculptors of synaptic plasticity DOI
Laura Sancho, Minerva Contreras, Nicola J. Allen

et al.

Neuroscience Research, Journal Year: 2020, Volume and Issue: 167, P. 17 - 29

Published: Dec. 11, 2020

Language: Английский

Citations

125

Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability DOI
Balázs Pál

Cellular and Molecular Life Sciences, Journal Year: 2018, Volume and Issue: 75(16), P. 2917 - 2949

Published: May 15, 2018

Language: Английский

Citations

114

GABAergic‐astrocyte signaling: A refinement of inhibitory brain networks DOI Creative Commons
Sara Mederos, Gertrudis Perea

Glia, Journal Year: 2019, Volume and Issue: 67(10), P. 1842 - 1851

Published: May 30, 2019

Abstract Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes integral elements synaptic transmission. However, interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based particular interneuron cell type, GABAergic‐astrocyte interplay would be involved diverse outcomes function. In this review, we will highlight current data supporting existence dynamic communication its impact inhibitory‐regulated responses, bringing new perspectives ways might contribute efficient neuronal coding.

Language: Английский

Citations

103

Astroglial Calcium Signaling Encodes Sleep Need in Drosophila DOI Creative Commons
Ian D. Blum, Mehmet F. Keleş, El‐Sayed Baz

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 31(1), P. 150 - 162.e7

Published: Nov. 12, 2020

Language: Английский

Citations

92

Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors DOI Creative Commons
Yulan Li, Lixuan Li, Jintao Wu

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Sept. 1, 2020

Astrocytes respond to and regulate neuronal activity, yet their role in mammalian behavior remains incompletely understood. Especially unclear is whether, if so how, astrocyte activity regulates contextual fear memory, the dysregulation of which leads pathological fear-related disorders. We generated GFAP-ChR2-EYFP rats allow specific activation astrocytes vivo by optogenetics. found that after memory acquisition within a temporal window, disrupted consolidation persistently decreased but not cued accompanied reduced anxiety behavior. In microdialysis experiments showed photoactivation increased extracellular ATP adenosine concentrations. Intracerebral blockade A 1 receptors (A Rs) reversed attenuation memory. Furthermore, intracerebral or intraperitoneal injection R agonist mimicked effects activation. Therefore, our findings provide deeper understanding astrocyte-mediated regulation suggest new important therapeutic strategy against

Language: Английский

Citations

90

Generating Brain Waves, the Power of Astrocytes DOI Creative Commons
Yossi Buskila, Alba Bellot-Saez, John W. Morley

et al.

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: Oct. 18, 2019

Synchronization of neuronal activity in the brain underlies emergence oscillations termed ‘Brain waves’, which serve various physiological functions and correlate with different behavioural states. It has been postulated that at least ten distinct mechanisms are involved formulation these waves, including variations concentration extracellular neurotransmitters ions, as well changes cellular excitability. In this mini-review,​ we highlight contribution astrocytes, a subtype glia, formation modulation waves mainly due to their close association synapses allows bidirectional interaction neurons, syncytium-like via gap junctions facilitate communication distal regions through Ca2+ waves. These capabilities allow astrocytes regulate excitability glutamate uptake, gliotransmission tight control K+ levels process clearance. Spatio-temporal synchrony across astrocytic networks, both locally distributed cortical regions, underpins states thereby behavioral states, it is becoming apparent play an important role development maintenance neural underlying complex

Language: Английский

Citations

83