Astrocyte–Neuron Networks: A Multilane Highway of Signaling for Homeostatic Brain Function

Frontiers in Synaptic Neuroscience, Journal Year: 2018, Volume and Issue: 10

Published: Nov. 27, 2018

Research on glial cells over the past 30 years has confirmed critical role of astrocytes in pathophysiological brain states. However, most our knowledge about astrocyte physiology and interactions between neurons is based premises that constitute a homogeneous cell type, without considering particular properties circuits or nuclei which are located. Therefore, we argue more-sophisticated experiments required to elucidate specific features different regions, even within layers circuit. Thus, addition diverse mechanisms used by communicate with synaptic partners, it necessary take into account cellular heterogeneity likely contributes outcomes astrocyte-neuron signaling. In this review article, briefly summarize current data regarding anatomical, molecular functional communication, as well communication.

Language: Английский

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Astrocytes modulate sensory-evoked neuronal network activity

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: July 23, 2020

While neurons principally mediate brain function, astrocytes are emerging as cells with important neuromodulatory actions in physiology. In addition to homeostatic roles, respond neurotransmitters calcium transients stimulating the release of gliotransmitters that regulate synaptic and neuronal functions. We investigated astrocyte-neuronal network interactions vivo by combining two-photon microscopy monitor astrocyte electrocorticogram record activity somatosensory cortex during sensory stimulation. found stimuli a stimulus-dependent manner. Sensory elicit surge gamma range (30-50 Hz) followed delayed dampens steady-state activity. This sensory-evoked increase is enhanced transgenic mice impaired signaling decreased pharmacogenetic stimulation astrocytes. Therefore, cortical inputs maximizing its dynamic range.

Language: Английский

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GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 24(1), P. 82 - 92

Published: Dec. 7, 2020

Language: Английский

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Glia as sculptors of synaptic plasticity

Neuroscience Research, Journal Year: 2020, Volume and Issue: 167, P. 17 - 29

Published: Dec. 11, 2020

Language: Английский

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Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

Cellular and Molecular Life Sciences, Journal Year: 2018, Volume and Issue: 75(16), P. 2917 - 2949

Published: May 15, 2018

Language: Английский

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GABAergic‐astrocyte signaling: A refinement of inhibitory brain networks

Glia, Journal Year: 2019, Volume and Issue: 67(10), P. 1842 - 1851

Published: May 30, 2019

Abstract Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes integral elements synaptic transmission. However, interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based particular interneuron cell type, GABAergic‐astrocyte interplay would be involved diverse outcomes function. In this review, we will highlight current data supporting existence dynamic communication its impact inhibitory‐regulated responses, bringing new perspectives ways might contribute efficient neuronal coding.

Language: Английский

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Astroglial Calcium Signaling Encodes Sleep Need in Drosophila

Current Biology, Journal Year: 2020, Volume and Issue: 31(1), P. 150 - 162.e7

Published: Nov. 12, 2020

Language: Английский

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Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Sept. 1, 2020

Astrocytes respond to and regulate neuronal activity, yet their role in mammalian behavior remains incompletely understood. Especially unclear is whether, if so how, astrocyte activity regulates contextual fear memory, the dysregulation of which leads pathological fear-related disorders. We generated GFAP-ChR2-EYFP rats allow specific activation astrocytes vivo by optogenetics. found that after memory acquisition within a temporal window, disrupted consolidation persistently decreased but not cued accompanied reduced anxiety behavior. In microdialysis experiments showed photoactivation increased extracellular ATP adenosine concentrations. Intracerebral blockade A 1 receptors (A Rs) reversed attenuation memory. Furthermore, intracerebral or intraperitoneal injection R agonist mimicked effects activation. Therefore, our findings provide deeper understanding astrocyte-mediated regulation suggest new important therapeutic strategy against

Language: Английский

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Generating Brain Waves, the Power of Astrocytes

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: Oct. 18, 2019

Synchronization of neuronal activity in the brain underlies emergence oscillations termed ‘Brain waves’, which serve various physiological functions and correlate with different behavioural states. It has been postulated that at least ten distinct mechanisms are involved formulation these waves, including variations concentration extracellular neurotransmitters ions, as well changes cellular excitability. In this mini-review,​ we highlight contribution astrocytes, a subtype glia, formation modulation waves mainly due to their close association synapses allows bidirectional interaction neurons, syncytium-like via gap junctions facilitate communication distal regions through Ca2+ waves. These capabilities allow astrocytes regulate excitability glutamate uptake, gliotransmission tight control K+ levels process clearance. Spatio-temporal synchrony across astrocytic networks, both locally distributed cortical regions, underpins states thereby behavioral states, it is becoming apparent play an important role development maintenance neural underlying complex

Language: Английский

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Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 1, 2020

Abstract Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3 rd postnatal week in mice, disappearing during 4 th week. At more mature stages, we found that protocol induced t-LTD t-LTP. We characterized this form of t-LTP and mechanisms involved its induction, as well driving switch from to expressed presynaptically synapses, witnessed by coefficient variation, number failures, paired-pulse ratio miniature responses analysis. Additionally, presynaptic does not require NMDARs but activation mGluRs entry Ca 2+ into postsynaptic neuron through L-type voltage-dependent channels release intracellular stores. Nitric oxide also required a messenger neuron. Crucially, adenosine glutamate astrocytes for induction Thus, have discovered developmental synaptic transmission which play central role revealed LTP rules induction.

Language: Английский

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