Behavioral discrimination and olfactory bulb encoding of odor plume intermittency DOI Creative Commons
Ankita Gumaste, Keeley L. Baker,

Michelle Izydorczak

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: March 5, 2024

In order to survive, animals often need navigate a complex odor landscape where odors can exist in airborne plumes. Several plume properties change with distance from the source, providing potential navigational cues searching animals. Here, we focus on intermittency, temporal property that measures fraction of time is above threshold at given point within and decreases increasing source. We sought determine if mice use changes intermittency locate an To do so, trained discrimination task. establish discriminate samples low high neural responses olfactory bulb account for task performance support encoding. Modulation sniffing, behavioral parameter highly dynamic during odor-guided navigation, affects both outcome representation intermittency. Together, this work demonstrates inform search more broadly supports notion mammalian odor-based navigation be guided by properties.

Language: Английский

Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning DOI Creative Commons
Annie Handler, Thomas G.W. Graham, Raphael Cohn

et al.

Cell, Journal Year: 2019, Volume and Issue: 178(1), P. 60 - 75.e19

Published: June 1, 2019

Language: Английский

Citations

226
Algorithms for Olfactory Search across Species DOI Creative Commons
Keeley L. Baker, Michael H. Dickinson, Teresa M Findley

et al.

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(44), P. 9383 - 9389

Published: Oct. 31, 2018

Localizing the sources of stimuli is essential. Most organisms cannot eat, mate, or escape without knowing where relevant originate. For many, if not most, animals, olfaction plays an essential role in search. While microorganismal chemotaxis relatively well understood, larger animals algorithms and mechanisms olfactory search remain mysterious. In this symposium, we will present recent advances our understanding flies rodents. Despite their different sizes behaviors, both species must solve similar problems, including meeting challenges turbulent airflow, sampling environment to optimize information, incorporating odor information into broader navigational systems.

Language: Английский

Citations

163
A neural circuit for wind-guided olfactory navigation DOI Creative Commons
Andrew M. M. Matheson, Aaron J. Lanz,

Ashley M. Medina

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 8, 2022

Abstract To navigate towards a food source, animals frequently combine odor cues about source identity with wind direction location. Where and how these two are integrated to support navigation is unclear. Here we describe pathway the Drosophila fan-shaped body that encodes attractive promotes upwind navigation. We show neurons throughout this encode odor, but not direction. Using connectomics, identify local called h∆C receive input from previously described pathway. exhibit odor-gated, direction-tuned activity, sparse activation of in reproducible direction, activity required for persistent orientation during odor. Based on connectome data, develop computational model showing can promote goal such as an source. Our results suggest processed by separate pathways within goal-directed

Language: Английский

Citations

91
Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila DOI Creative Commons
Daichi Yamada, Daniel Bushey, Feng Li

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 24, 2023

Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify feedforward circuit formed between dopamine show that essential for second-order conditioning, an ethologically important form of higher-order associative The Drosophila mushroom body comprises series dopaminergic compartments, each which exhibits dynamics. We find slow stable compartment can serve as effective ‘teacher’ by instructing other faster transient compartments via single key interneuron, connectome analysis neurotransmitter prediction. This excitatory interneuron acquires enhanced response to reward-predicting odor after first-order conditioning and, upon activation, evokes release the ‘student’ compartments. These hierarchical connections explain first- long known behavioral psychologists.

Language: Английский

Citations

43
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila DOI Creative Commons
Sercan Sayın, Jean‐François De Backer,

K.P. Siju

et al.

Neuron, Journal Year: 2019, Volume and Issue: 104(3), P. 544 - 558.e6

Published: Aug. 27, 2019

In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion fear. How need motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that flies persistently track food odor increase their effort over repeated trials in absence reward suggesting dominates negative experience. We further tracking regulated by two mushroom body output neurons (MBONs) connecting MB lateral horn. These MBONs, together with dopaminergic Dop1R2 signaling, behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one acts as brake on feeding olfaction. Together, our data suggest function for internal state-dependent expression can be suppressed external inputs conveying competing drive.

Language: Английский

Citations

127
A Neural Network for Wind-Guided Compass Navigation DOI Creative Commons

Tatsuo S. Okubo,

Paola Patella, Isabel D’Alessandro

et al.

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 924 - 940.e18

Published: July 17, 2020

Spatial maps in the brain are most accurate when they linked to external sensory cues. Here, we show that compass Drosophila is direction of wind. Shifting wind rightward rotates as if fly were turning leftward, and vice versa. We describe mechanisms several computations integrate information into compass. First, an intensity-invariant representation computed by comparing left-right mechanosensory signals. Then, signals reformatted reduce coding biases inherent peripheral mechanics, cues brought same circular coordinate system represents visual self-motion Because incorporates both cues, it should enable navigation under conditions where no single cue consistently reliable. These results how local can be transformed a global, multimodal, abstract space.

Language: Английский

Citations

106
Encoding of Wind Direction by Central Neurons in Drosophila DOI Creative Commons
Marie P. Suver, Andrew M. M. Matheson,

Sinekdha Sarkar

et al.

Neuron, Journal Year: 2019, Volume and Issue: 102(4), P. 828 - 842.e7

Published: April 1, 2019

Language: Английский

Citations

92
Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters DOI Creative Commons
Mahmut Demir, Nirag Kadakia, Hope D. Anderson

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 3, 2020

How insects navigate complex odor plumes, where the location and timing of packets are uncertain, remains unclear. Here we imaged plumes simultaneously with freely-walking flies, quantifying how behavior is shaped by encounters individual packets. We found that navigation was stochastic did not rely on continuous modulation speed or orientation. Instead, flies turned stochastically stereotyped saccades, whose direction biased upwind prior encounters, while magnitude rate saccades remained constant. Further, used to modulate transition rates between walks stops. In more regular environments, continuously orientation, even though can still occur randomly due animal motion. find in less predictable random both space time, walking encounter timing.

Language: Английский

Citations

89
Olfactory Sensing and Navigation in Turbulent Environments DOI
Gautam Reddy, Venkatesh N. Murthy, Massimo Vergassola

et al.

Annual Review of Condensed Matter Physics, Journal Year: 2021, Volume and Issue: 13(1), P. 191 - 213

Published: Nov. 9, 2021

Fluid turbulence is a double-edged sword for the navigation of macroscopic animals, such as birds, insects, and rodents. On one hand, enables pheromone communication among mates possibility locating food by their odors from long distances. Molecular diffusion would indeed be unable to spread over relevant distances in natural conditions. other turbulent flows are hard predict, learning effective maneuvers navigate them challenging, we discuss this review. We first provide summary olfactory organs that sense airborne or surface-bound odors, well computational tasks animals face when extracting information useful an signal. A compendium dynamics transport emphasizes those aspects directly impact animals’ behavior. The state art on navigational strategies discussed, followed concluding section dedicated future challenges field.

Language: Английский

Citations

69
Sniff-synchronized, gradient-guided olfactory search by freely moving mice DOI Creative Commons
Teresa M Findley, David G Wyrick,

Jennifer L Cramer

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: May 4, 2021

For many organisms, searching for relevant targets such as food or mates entails active, strategic sampling of the environment. Finding odorous may be most ancient search problem that motile organisms evolved to solve. While chemosensory navigation has been well characterized in microorganisms and invertebrates, spatial olfaction vertebrates is poorly understood. We have established an olfactory assay which freely moving mice navigate noisy concentration gradients airborne odor. Mice solve this task using gradient cues do not require stereo performance. During performance, respiration nose movement are synchronized with tens milliseconds precision. This synchrony present during trials largely absent inter-trial intervals, suggesting sniff-synchronized a behavioral state rather than simply constant accompaniment fast breathing. To reveal spatiotemporal structure these active sensing movements, we used machine learning methods parse motion trajectories into elementary motifs. Motifs fall two clusters, correspond investigation approach states. Investigation motifs lock precisely sniffing, individual preferentially occur at specific phases sniff cycle. The allocentric indicates advantage both sides sharpest part odor gradient, consistent serial-sniff strategy sensing. work clarifies sensorimotor strategies mouse guides ongoing underlying neural mechanisms.

Language: Английский

Citations

60