Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
29(2), P. 412 - 424
Published: Dec. 5, 2023
Abstract
Oxytocin
plays
an
important
role
in
modulating
social
recognition
memory.
However,
the
direct
implication
of
oxytocin
neurons
paraventricular
nucleus
hypothalamus
(PVH)
and
their
downstream
hypothalamic
targets
regulating
short-
long-term
forms
memory
has
not
been
fully
investigated.
In
this
study,
we
employed
a
chemogenetic
approach
to
target
activity
PVH
male
rats
found
that
specific
silencing
neuronal
population
led
impairment
We
combined
viral-mediated
fluorescent
labeling
with
immunohistochemical
techniques
identified
supramammillary
(SuM)
as
oxytocinergic
axonal
projections
rats.
used
multiplex
fluorescence
situ
hybridization
label
receptors
SuM
determined
they
are
predominantly
expressed
glutamatergic
neurons,
including
those
project
CA2
region
hippocampus.
Finally,
highly
selective
receptor
antagonist
examine
involvement
signaling
it
is
necessary
for
formation
both.
This
study
discovered
previously
undescribed
via
reinforced
form
Journal of Neuroscience,
Journal Year:
2023,
Volume and Issue:
43(45), P. 7554 - 7564
Published: Nov. 8, 2023
The
cerebellum,
traditionally
associated
with
motor
coordination
and
balance,
also
plays
a
crucial
role
in
various
aspects
of
higher-order
function
dysfunction.
Emerging
research
has
shed
light
on
the
cerebellum's
broader
contributions
to
cognitive,
emotional,
reward
processes.
influence
autonomic
further
highlights
its
significance
regulating
motivational
emotional
states.
Perturbations
cerebellar
development
have
been
implicated
neurodevelopmental
disorders,
including
autism
spectrum
disorder
attention
deficit
hyperactivity
disorder.
An
increasing
appreciation
for
neuropsychiatric
symptoms
that
arise
from
dysfunction
underscores
importance
elucidating
circuit
mechanisms
underlie
complex
interactions
between
cerebellum
other
brain
regions
comprehensive
understanding
behavior.
By
briefly
discussing
new
advances
mapping
affective,
autonomic,
social
processing
reviewing
neuropathology
beyond
domain,
this
Mini-Symposium
review
aims
provide
broad
perspective
intersections
limbic
health
disease.
iScience,
Journal Year:
2020,
Volume and Issue:
23(3), P. 100894 - 100894
Published: Feb. 11, 2020
Ventral
hippocampus
(vHIP)
and
medial
prefrontal
cortex
(mPFC)
are
both
critical
regions
for
social
behaviors.
However,
how
their
interactions
affect
behavior
is
not
well
understood.
By
viral
tracing,
optogenetics,
chemogenetics,
fiber
photometry,
we
demonstrated
that
inhibition
of
vHIP
or
direct
projections
from
to
mPFC
impaired
memory
expression.
Via
rabies
retrograde
found
all
three
major
GABAergic
neurons
in
received
inputs
vHIP.
Activation
parvalbumin
positive
(PV+)
but
somatostatin
(SST+)
can
rescue
the
impairment
caused
by
inhibition.
Furthermore,
photometry
results
behaviors
preferentially
recruited
PV+
hippocampal
disrupted
activity
during
interactions.
These
revealed
a
new
mechanism
regulate
complementarity
with
existing
neural
circuitry
mechanism.
Current Biology,
Journal Year:
2020,
Volume and Issue:
30(19), P. 3761 - 3774.e6
Published: Aug. 20, 2020
Birth
by
Caesarean
(C)-section
impacts
early
gut
microbiota
colonization
and
is
associated
with
an
increased
risk
of
developing
immune
metabolic
disorders.
Moreover,
alterations
the
microbiome
have
been
shown
to
affect
neurodevelopmental
trajectories.
However,
long-term
effects
C-section
on
neurobehavioral
processes
remain
unknown.
Here,
we
demonstrated
that
birth
results
in
marked
but
transient
changes
composition
mouse,
particular,
abundance
Bifidobacterium
spp.
was
depleted
life.
Mice
born
had
enduring
social,
cognitive,
anxiety
deficits
life
adulthood.
Interestingly,
found
these
specific
behavioral
induced
mode
were
also
partially
corrected
co-housing
vaginally
mice.
Finally,
showed
supplementation
from
a
breve
strain,
or
dietary
prebiotic
mixture
stimulates
growth
bifidobacteria,
reverses
selective
Taken
together,
our
data
link
C-section-born
mice
suggest
possibility
adjunctive
microbiota-targeted
therapies
may
help
avert
negative
consequences
behavior
mode.
Frontiers in Behavioral Neuroscience,
Journal Year:
2021,
Volume and Issue:
15
Published: June 21, 2021
Despite
decades
of
research
on
the
neurobiology
major
depressive
disorder
(MDD),
mechanisms
underlying
its
expression
remain
unknown.
The
medial
prefrontal
cortex
(mPFC),
a
hub
region
involved
in
emotional
processing
and
stress
response
elaboration,
is
highly
impacted
MDD
patients
animal
models
chronic
stress.
Recent
advances
showed
alterations
morphology
activity
mPFC
neurons
along
with
profound
changes
their
transcriptional
programs.
Studies
at
circuitry
level
highlighted
relevance
deciphering
contributions
distinct
circuits
elaboration
adapted
maladapted
behavioral
responses
context
Interestingly,
presents
sexual
dimorphism,
feature
recognized
molecular
field
but
understudied
circuit
level.
This
review
examines
recent
literature
summarizes
contribution
males
females
morphological
functional
that
change
these
neuronal
human
depressive-like
behaviors.
Philosophical Transactions of the Royal Society B Biological Sciences,
Journal Year:
2022,
Volume and Issue:
377(1845)
Published: Jan. 10, 2022
Across
species,
animals
organize
into
social
dominance
hierarchies
that
serve
to
decrease
aggression
and
facilitate
survival
of
the
group.
Neuroscientists
have
adopted
several
model
organisms
study
in
laboratory
setting,
including
fish,
reptiles,
rodents
primates.
We
review
recent
literature
across
species
sheds
light
onto
how
brain
represents
rank
guide
socially
appropriate
behaviour
within
a
hierarchy.
First,
we
discuss
responds
status
signals.
Then,
approach
avoidance
learning
mechanisms
propose
could
drive
rank-appropriate
behaviour.
Lastly,
memories
individuals
(social
memory)
this
may
support
maintenance
unique
individual
relationships
This
article
is
part
theme
issue
‘The
centennial
pecking
order:
current
state
future
prospects
for
hierarchies’.
