International Journal of Obesity,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Feb. 1, 2023
Abstract
Background/Objective
As
the
obesity
epidemic
continues,
understanding
of
macronutrient
influence
on
central
nervous
system
function
is
critical
for
diet-induced
and
potential
therapeutics,
particularly
in
light
increased
sugar
content
processed
foods.
Previous
research
showed
mixed
effects
sucrose
feeding
body
weight
gain
but
has
yet
to
reveal
insight
into
impact
hypothalamic
functioning.
Here,
we
explore
liquid
12
weeks
weight,
composition,
caloric
intake,
AgRP
neuronal
synaptic
plasticity.
Methods
Patch-clamp
electrophysiology
neurons,
metabolic
phenotyping
food
intake
were
performed
C57BL/6J
mice.
Results
While
mice
given
sugar-sweetened
water
do
not
significant
they
show
subtle
differences
composition
intake.
When
water,
similar
alterations
excitability
as
high-fat
diet
obese
models.
Increased
consumption
also
primes
when
access
a
HFD.
Conclusions
Our
results
that
elevated
activity
neurons
altered
excitability.
This
may
contribute
humans
with
more
palatable
(HFD)
diets.
Frontiers in Molecular Neuroscience,
Journal Year:
2023,
Volume and Issue:
16
Published: July 4, 2023
Sex
bias
has
been
an
issue
in
many
biomedical
fields,
especially
neuroscience.
In
rodent
research,
scientists
only
focused
on
male
animals
due
to
the
belief
that
female
estrous
cycle
gives
rise
unacceptable,
high
levels
of
variance
experiments.
However,
even
though
sexual
behaviors
are
well
known
be
regulated
by
cycle,
which
effects
other
non-sexual
were
not
always
consistent
previous
reports.
Recent
reviews
analyzing
published
literature
suggested
there
is
no
evidence
for
larger
variation
than
several
phenotypes.To
further
investigate
impact
variability
behaviors,
we
conducted
multiple
behavioral
assays,
including
open
field
test,
forced
swimming
and
resident-intruder
assay
assess
anxiety-,
depression-like
as
social
interaction
respectively.
We
compared
females
estrus
diestrus
stages
across
four
different
mouse
strains:
C57BL/6,
BALB/c,
C3H,
DBA/2.Our
results
found
significant
difference
most
parameters
between
these
two
stages.
On
hand,
differences
among
certain
strains
relatively
both
stages,
suggesting
a
very
minimal
effect
detecting
difference.
Last,
similar
variations
sexes.While
our
study
successfully
identified
sexes,
did
find
solid
support
notion
influenced
cycle.
Additionally,
observed
males
females.
Female
mice,
therefore,
have
reason
excluded
future
research.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 19, 2023
Social
grouping
increases
survival
in
many
species,
including
humans1,2.
By
contrast,
social
isolation
generates
an
aversive
state
(loneliness)
that
motivates
seeking
and
heightens
interaction
upon
reunion3-5.
The
observed
rebound
triggered
by
suggests
a
homeostatic
process
underlying
the
control
of
drive,
similar
to
for
physiological
needs
such
as
hunger,
thirst
or
sleep3,6.
In
this
study,
we
assessed
responses
multiple
mouse
strains
identified
FVB/NJ
line
exquisitely
sensitive
isolation.
Using
mice,
uncovered
two
previously
uncharacterized
neuronal
populations
hypothalamic
preoptic
nucleus
are
activated
during
orchestrate
behavior
display
need
satiety,
respectively.
We
direct
connectivity
between
these
opposite
function
with
brain
areas
associated
behavior,
emotional
state,
reward,
needs,
showed
animals
require
touch
assess
presence
others
fulfill
their
need,
thus
revealing
brain-wide
neural
system
homeostasis.
These
findings
offer
mechanistic
insight
into
nature
circuits
controlling
instinctive
understanding
healthy
diseased
states
context.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(18), P. 10816 - 10816
Published: Sept. 16, 2022
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
and
the
most
common
form
of
dementia.
Approximately
50%
AD
patients
show
anxiety
depressive
symptoms,
which
may
contribute
to
cognitive
decline.
We
aimed
investigate
whether
triple-transgenic
mouse
(3xTg-AD)
good
preclinical
model
this
co-morbidity.
The
characteristic
histological
hallmarks
are
known
appear
around
6-month;
thus,
4-
8-month-old
male
mice
were
compared
with
age-matched
controls.
A
behavioral
test
battery
was
used
examine
anxiety-
(open
field
(OF),
elevated
plus
maze,
light-dark
box,
novelty
suppressed
feeding,
social
interaction
(SI)
tests),
depression-like
symptoms
(forced
swim
test,
tail
suspension
sucrose
preference
splash
learned
helplessness)
as
well
decline
(Morris
water
maze
(MWM)
discrimination
(SD)
tests).
Acetylcholinesterase
histochemistry
visualized
cholinergic
fibers
in
cortex.
Dexamethasone-test
evaluated
glucocorticoid
non-suppression.
In
MWM,
3xTg-AD
found
platform
later
than
controls
cohort.
SD
abilities
missing
at
both
ages.
OF,
age
groups
moved
significantly
less
During
SI,
animals
spent
time
friendly
behavior
groomed
themselves
Cortical
fiber
density
lower
control.
Dexamethasone
non-suppression
detectable
4-month-old
group.
All
all,
some
depressive-like
present
mice.
Although
strain
not
generally
more
anxious
or
depressed,
aspects
comorbidity
might
be
studied
selected
tests,
help
develop
new
possible
treatments.
Alcohol Clinical and Experimental Research,
Journal Year:
2024,
Volume and Issue:
48(8), P. 1586 - 1599
Published: June 20, 2024
Exposure
to
stress
during
childhood
and
adolescence
is
a
risk
factor
for
alcohol
use
disorder
(AUD)
comorbid
conditions,
including
posttraumatic
(PTSD).
We
previously
established
an
adolescent
social
isolation
(SI)
model
that
leads
the
emergence
of
wide
range
behavioral
factors
AUD,
increased
anxiety-like
behavior,
locomotor
activity,
ethanol
consumption
in
male
female
rats.
Here,
we
sought
test
hypothesis
SI
may
increase
vulnerability
single
prolonged
(SPS),
rodent
PTSD.
