Stress-induced changes in cognitive function and intestinal barrier integrity can be ameliorated by venlafaxine and synbiotic supplementations

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17033 - e17033

Published: Feb. 28, 2024

Stress profoundly impacts various aspects of both physical and psychological well-being. Our previous study demonstrated that venlafaxine (Vlx) synbiotic (Syn) treatment attenuated learned fear-like behavior recognition memory impairment in immobilized-stressed rats. In this study, we further investigated the physical, behavior, cellular mechanisms underlying effects Syn and/or Vlx on brain intestinal functions stressed Adult male Wistar rats, aged 8 weeks old were subjected to 14 days immobilization stress showed a decrease body weight gain food intake as well an increase water consumption, urinary corticosterone levels, adrenal gland weight. Supplementation rats resulted mitigation loss, restoration normal fluid intake, normalization levels. Behavioral analysis with enhanced depressive-like behaviors improved spatial learning-memory Hippocampal dentate gyrus stress-induced neuronal cell death, which was by treatment. Stress-induced ileum inflammation increased permeability effectively reduced supplementation Syn. addition, partly contributed affecting expression glial cell-derived neurotrophic factor hippocampus intestines suggesting particularly protective gut barrier brain. This highlights intricate interplay between physiological responses gut. intervention alleviate death modulate depression- impairment-like behaviors, improve dysfunction similar those Vlx. These findings enhance our understanding stress-related health conditions suggest may be promising approach ameliorate deleterious gut-brain axis.

Language: Английский

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Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115239 - 115239

Published: Feb. 1, 2025

Language: Английский

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Design of Anti-depressant Phosphodiester Amino Acidic Keap1-Nrf2 Protein-Protein Interaction Inhibitors

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103620 - 103620

Published: March 1, 2025

Inhibiting the protein-protein interaction (PPI) between Keap1 and Nrf2 is theoretically an effective safe strategy for activation of pathway to treat major depressive disorder (MDD). In this study, through bioinformatic analysis brain tissues peripheral blood MDD patients mice, we confirmed involvement oxidative stress, inflammation, Keap1-Nrf2 in depression. Subsequently, developed a series phosphodiester amino acidic diaminonaphthalene compounds as PPI inhibitors first time. Screening using LPS-stimulated SH-SY5Y BV2 cell models identified compound 4-95 showing best anti-oxidative stress anti-inflammatory efficacy. The ability penetrate blood-brain-barrier was significantly enhanced. chronic unpredictable mild mouse model, treatment with effectively ameliorated anxiety depression behavior restored serum neurotransmitter levels by promoting nuclear translocation. Consequently, reduced, expression synaptic plasticity biomarkers, such postsynaptic density protein 95 (PSD95) synapsin 1 (SYN1) were increased, suggesting recovery neuronal function. Collectively, our findings demonstrate that inhibitor holds great promise preclinical candidate

Language: Английский

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Comprehensive insights into emerging advances in the Neurobiology of anorexia

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Anorexia is a complex eating disorder influenced by genetic, environmental, psychological, and socio-cultural factors. Research into its molecular mechanisms neural circuits has deepened our understanding of pathogenesis. Recent advances in neuroscience, biology, genetics have revealed key circuit underlying anorexia. Aim review Clarify the peripheral central regulating various types anorexia, identify cytokines circuits, propose new strategies for treatment. Key scientific concepts animal models, including activity-induced, genetic mutation, inflammation-induced types, are explored their relevance to studying disorder. Anorexic behavior regulated cytokines, hormones (like GDF15, GLP-1, leptin), such as AgRP, serotonergic, dopaminergic, glutamatergic pathways. Disruptions these pathways, GABAergic signaling AgRP neurons 5-HT2C D2 receptors, contribute Potential therapies target neurotransmitter ghrelin GDF15-GFRAL pathway, offering insights treating immune responses, obesity.

Language: Английский

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Behavioural and physiological effects of binge eating: a systematic review and meta-analysis of animal models

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106135 - 106135

Published: April 1, 2025

Binge eating is defined as abnormally large amounts in a brief period of time. Many animal studies have examined the behavioural and physiological effects binge high-fat, high-sugar foods to model consequences human eating. The present systematic review 199 rodent sought identify determine whether changes were specific or general exposure palatable diet. A meta-analysis 18 revealed that produces greater anxiety-like behaviour on Elevated Plus-Maze with small effect size significant funnel plot asymmetry, suggesting true overestimated. history binge-like access generally increases progressive ratio breakpoint for binged food, without altering 'liking' measured by lick microstructure, dissociable 'wanting' but not accompany contribute its persistence. appears enhance compulsive food-seeking prevent stress-induced reductions intake does appear alter depression-like locomotor activity. Notably, may produce comparable metabolic impairments those observed after extended continuous diet despite no overall body weight outcomes most studies.

Language: Английский

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Voluntary wheel running promotes resilience to the behavioral effects of unpredictable chronic mild stress in male and female mice

Stress, Journal Year: 2023, Volume and Issue: 26(1)

Published: Jan. 2, 2023

Besides significant benefits to physical health, exercise promotes mental reduces symptoms of illness, and enhances psychological development. Exercise can offset the impact chronic stress, which is a major precursor development disorders. The effects on stress-induced behaviors are contradictory in preclinical studies, primarily due lack data sex-specific investigations. We sought evaluate behavioral changes both male female mice. Mice were subjected an Unpredictable Chronic Mild Stress (UCMS) paradigm with accessibility running wheels for 2 h daily. Physiological evaluations conducted throughout stress determine if blunts UCMS. induced voluntary wheel (VWR) weight loss Compared males, increased VWR was reported females who also regained their lost by end UCMS protocol. promoted resilience hyponeophagia novelty-suppressed feeding test sucrose consumption. reduction immobility avoidance behavior tail suspension open field tests exploratory light-dark test. These results indicate that promote males females, affect independent stress.

Language: Английский

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Electronic Vaporization of Nicotine Salt or Freebase produces differential effects on metabolism, neuronal activity and behavior in male and female C57BL/6J mice

Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 6, P. 100082 - 100082

Published: March 30, 2023

The use of Electronic Nicotine Delivery Systems (ENDS) is increasing in prevalence and popularity. ENDS are a rapidly evolving technology as devices e-liquid formulations adapt to policy restrictions market demand To identify the impacts nicotine formulation concentration, we exposed female male C57BL/6J mice passive electronic vaporization different (freebase or salt) concentrations (1% 3%) measured serum metabolite levels, brain activity by cFos expression, anxiety-like motivated behavior using novelty suppressed feeding test. We found that 3% freebase vapor group displayed significantly higher levels than either 1% salt formulations, cotinine compared males. Central amygdala (CeA) was elevated following exposure, but increase not between groups. CeA unaffected. In contrast increased ventral tegmental area (VTA) only observed specifically dopaminergic population. Anxiety-like relatively unaffected however reduced motivation feed after group. These results important sex differences impact concentration on metabolism, region-specific behavior, which may have significant relevance for consequences vaping men women.

Language: Английский

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11‐Ethoxyviburtinal improves chronic restraint stress‐induced anxiety‐like behaviors in gender‐specific mice via PI3K/Akt and E₂/ERβ signaling pathways

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(9), P. 4149 - 4165

Published: June 9, 2023

Abstract Anxiety disorder is a chronic and disabling psychiatric that more prevalent in females than males. 11‐Ethoxyviburtinal an iridoid extracted from Valeriana jatamansi Jones , which has anxiolytic potential. The aim of the present work was to study efficacy mechanism 11‐ethoxyviburtinal gender‐specific mice. We first evaluated anxiolytic‐like restraint stress (CRS) mice different sexes through behavioral experiments biochemical indexes. In addition, network pharmacology molecular docking were used predict potential targets important pathways for treatment anxiety with 11‐ethoxyviburtinal. Finally, influence on phosphoinositide‐3‐kinase (PI3K)/protein kinase B (Akt) signaling pathway, estrogen receptor β (ERβ) expression, anxiety‐like behavior verified by western blotting, immunohistochemistry staining, antagonist intervention methods, experiments. alleviated behaviors induced CRS inhibited neurotransmitter dysregulation HPA axis hyperactivity. It abnormal activation PI3K/Akt modulated production, promoted ERβ expression female may be sensitive pharmacological effects exert its E2/ERβ pathways. Meanwhile, comparing male mice, gender differences affect therapy development disorder.

Language: Английский

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Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(4), P. 309 - 321

Published: Aug. 31, 2022

Language: Английский

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Osteoporosis under psychological stress: mechanisms and therapeutics

Life Medicine, Journal Year: 2024, Volume and Issue: 3(1)

Published: Feb. 1, 2024

Psychological stress has been associated with the onset of several diseases, including osteoporosis. However, underlying pathogenic mechanism remains unknown, and effective therapeutic strategies are still unavailable. Growing evidence suggests that sympathetic nervous system regulates bone homeostasis vascular function under psychological stress, as well coupling osteogenesis angiogenesis in development, remodeling, regeneration. Furthermore, extracellular vesicles (EVs), particularly mesenchymal stem cell (MSC-EVs), have emerged prospecting therapies for stimulating We summarize role regulation response to emphasize relationship between vessels bone. Finally, we suggest using MSC-EVs a promising method treating osteoporosis stress.

Language: Английский

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