High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight DOI Creative Commons
Austin C. Korgan, Klausen Oliveira-Abreu, Wei Wei

et al.

International Journal of Obesity, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 1, 2023

Abstract Background/Objective As the obesity epidemic continues, understanding of macronutrient influence on central nervous system function is critical for diet-induced and potential therapeutics, particularly in light increased sugar content processed foods. Previous research showed mixed effects sucrose feeding body weight gain but has yet to reveal insight into impact hypothalamic functioning. Here, we explore liquid 12 weeks weight, composition, caloric intake, AgRP neuronal synaptic plasticity. Methods Patch-clamp electrophysiology neurons, metabolic phenotyping food intake were performed C57BL/6J mice. Results While mice given sugar-sweetened water do not significant they show subtle differences composition intake. When water, similar alterations excitability as high-fat diet obese models. Increased consumption also primes when access a HFD. Conclusions Our results that elevated activity neurons altered excitability. This may contribute humans with more palatable (HFD) diets.

Language: Английский

Applying the Research Domain Criteria to Rodent Studies of Sex Differences in Chronic Stress Susceptibility DOI

Hannah M Campbell,

Jessica D Guo,

Cynthia M. Kuhn

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(11), P. 848 - 857

Published: May 29, 2024

Language: Английский

Citations

2
An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes DOI Creative Commons
Jing Cai, Yanyan Jiang, Yuanzhong Xu

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(3), P. 458 - 472.e6

Published: Dec. 5, 2023

Language: Английский

Citations

6
High fat diet blunts stress-induced hypophagia and activation of Glp1r dorsal lateral septum neurons in male but not in female mice DOI

Michelle B. Bales,

Samuel W. Centanni, Joseph R. Luchsinger

et al.

Molecular Metabolism, Journal Year: 2022, Volume and Issue: 64, P. 101571 - 101571

Published: Aug. 8, 2022

Language: Английский

Citations

9
Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background DOI Creative Commons

Garret L. Ryherd,

Averie L. Bunce,

Haley A. Edwards

et al.

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 156, P. 105439 - 105439

Published: Oct. 7, 2023

Language: Английский

Citations

5
High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight DOI Creative Commons
Austin C. Korgan, Klausen Oliveira-Abreu, Wei Wei

et al.

International Journal of Obesity, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 1, 2023

Abstract Background/Objective As the obesity epidemic continues, understanding of macronutrient influence on central nervous system function is critical for diet-induced and potential therapeutics, particularly in light increased sugar content processed foods. Previous research showed mixed effects sucrose feeding body weight gain but has yet to reveal insight into impact hypothalamic functioning. Here, we explore liquid 12 weeks weight, composition, caloric intake, AgRP neuronal synaptic plasticity. Methods Patch-clamp electrophysiology neurons, metabolic phenotyping food intake were performed C57BL/6J mice. Results While mice given sugar-sweetened water do not significant they show subtle differences composition intake. When water, similar alterations excitability as high-fat diet obese models. Increased consumption also primes when access a HFD. Conclusions Our results that elevated activity neurons altered excitability. This may contribute humans with more palatable (HFD) diets.

Language: Английский

Citations

4