State-Dependent tACS Effects Reveal the Potential Causal Role of Prestimulus Alpha Traveling Waves in Visual Contrast Detection

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(27), P. e2023232024 - e2023232024

Published: May 29, 2024

The intricate relationship between prestimulus alpha oscillations and visual contrast detection variability has been the focus of numerous studies. However, causal impact traveling waves on remains largely unexplored. In our research, we sought to discern link across different levels mental fatigue. Using electroencephalography alongside a task with 30 healthy adults (13 females; 17 males), identified robust negative correlation forward (FTWs) threshold (VCT). Inspired by this correlation, utilized 45/-45° phase-shifted transcranial alternating current stimulation (tACS) in sham-controlled, double-blind, within-subject experiment 33 (23 10 males) directly modulate these waves. After application 45° tACS, observed substantial decrease FTW an increase backward waves, along concurrent VCT, compared sham condition. These changes were particularly pronounced under low fatigue state. findings state-dependent tACS effects reveal potential role detection. Moreover, study highlights cognitive modulation therapeutic applications.

Language: Английский

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The neural and physiological substrates of real-world attention change across development.

Published: May 31, 2024

The ability to allocate and maintain visual attention enables us adaptively regulate perception action, guiding strategic behaviour within complex, dynamic environments. This capacity develops rapidly over the early years of life, underpins all subsequent cognitive development learning. From screen-based experiments we know something about how control is instantiated in developing brain, but currently understand little for dynamic, real-world settings. To address this, recorded brain activity, autonomic arousal spontaneous patterns N=58 5- 10-month-old infants during free play. We used time series analyses examine whether changes activity anticipate or follow on from them. Early infancy, slow-varying fluctuations forward-predicted attentional behaviours, cortical did not. By later fronto-central theta power associated with infants’ attentiveness predicted length durations. But crucially, followed, rather than preceded, shifts, suggesting that processes after an shift determine long episode will last. also found modulated at 10 not 5 months. Collectively, our results suggest modulation involves both arousal-based point important developmental transition. As progresses, systems become dynamically integrated gain greater modulating naturalistic

Language: Английский

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Comparison of undirected frequency-domain connectivity measures for cerebro-peripheral analysis

NeuroImage, Journal Year: 2021, Volume and Issue: 245, P. 118660 - 118660

Published: Oct. 29, 2021

Analyses of cerebro-peripheral connectivity aim to quantify ongoing coupling between brain activity (measured by MEG/EEG) and peripheral signals such as muscle activity, continuous speech, or physiological rhythms (such pupil dilation respiration). Due the distinct rhythmicity these signals, undirected is typically assessed in frequency domain. This leaves investigator with two critical choices, namely a) appropriate measure for spectral estimation (i.e., transformation into domain) b) actual measure. As there no consensus regarding best practice, a wide variety methods has been applied. Here we systematically compare combinations six standard (comprising fast Fourier wavelet transformation, bandpass filtering, short-time transformation) measures (phase-locking value, Gaussian-Copula mutual information, Rayleigh test, weighted pairwise phase consistency, magnitude squared coherence, entropy). We provide performance each combination simulated data (with precise control over true connectivity), single-subject set real MEG data, full group analysis data. Our results show that, overall, WPPC GCMI tend outperform other measures, while entropy was only sensitive bimodal deviations from uniform distribution. For analysis, choosing method appears be more than discuss practical implications (sampling rate, SNR, computation time, length) recommendations tailored particular research questions.

Language: Английский

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Behavioral impulsivity is associated with pupillary alterations and hyperactivity in CDKL5 mutant mice

Human Molecular Genetics, Journal Year: 2022, Volume and Issue: 31(23), P. 4107 - 4120

Published: July 21, 2022

Abstract Cyclin-dependent kinase-like 5 (Cdkl5) deficiency disorder (CDD) is a severe neurodevelopmental condition caused by mutations in the X-linked Cdkl5 gene. CDD characterized early-onset seizures first month of life, intellectual disability, motor and social impairment. No effective treatment currently available medical management only symptomatic supportive. Recently, mouse models have demonstrated that mice lacking exhibit autism-like phenotypes, hyperactivity dysregulations arousal system, suggesting possibility to use these features as translational biomarkers. In this study, we tested male female mutant an appetitive operant conditioning chamber assess cognitive abilities, performed pupillometry integrity system. Then, evaluated performance artificial intelligence classify genotype animals from behavioral physiological phenotype. The results show display impulsivity, together with low levels flexibility perseverative behaviors. We assessed simultaneously recording pupil size locomotor activity. Pupillometry reveals smaller impaired response unexpected stimuli associated hyperlocomotion, demonstrating global defect modulation. Finally, machine learning both parameters can be considered good predictors CDD. Since early diagnosis essential evaluate outcomes pupillary measures easily, proposed monitoring promising biomarker for

Language: Английский

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Spectral Fingerprints of Cortical Neuromodulation

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(18), P. 3836 - 3846

Published: March 31, 2022

Pupil size has been established as a versatile marker of noradrenergic and cholinergic neuromodulation, which profound effects on neuronal processing, cognition, behavior. However, little is known about the cortical control pupil-linked neuromodulation. Here, we show that pupil dynamics are tightly coupled to temporally, spectrally, spatially specific modulations local large-scale population activity in human brain. We quantified band-limited resting subjects using magnetoencephalography investigated how neural were linked simultaneously recorded dynamics. Our results neuromodulation does not merely affect stereotypical fashion. Instead, identified three frontal, precentral, occipitoparietal networks, with distinct spectral profiles theta, beta, alpha bands temporally preceded followed changes size. Furthermore, found amplitude coupling at ∼16 Hz frontoparietal network predicted unravel network-specific fingerprints brain likely reflect both causes SIGNIFICANCE STATEMENT Brain function constantly affected by modulatory neurotransmitters. because correlates largely unknown, fundamental questions remain unresolved. Which networks neuromodulation? Does or region-specific fashion? To address this, magnetoencephalography. highly four These effect

Language: Английский

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