Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 87 - 99
Published: Jan. 1, 2025
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 16, 2024
Abstract Animals select food based on hungers that reflect dynamic and specific macronutrient needs. Feeding behavior is governed by endocrine signals, but the hormonal mechanisms underlying nutrient-specific appetite regulation are poorly defined. We demonstrate gut hormone Tachykinin (Tk), an ortholog of mammalian Substance P, controls selective in Drosophila . When protein-rich consumed, enteroendocrine cells (EECs) midgut release Tk, which acts adipokinetic (AKH)-producing cells. AKH suppresses protein enhances sugar hunger, thus forming feedback system aligns choice with internal nutritional state. Inhibiting this protein-responsive increases fecundity also prolongs lifespan through AKH, revealing a role nutrient-dependent gut-hormone signaling influencing longevity. Our results provide framework for understanding EEC-derived satiety signals hormones lifespan.
Language: Английский
Citations
3
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 10, 2024
The communication between intestinal Glucagon like peptide 1 (GLP-1)-producing cells and the peripheral nervous system has garnered renewed interest considering availability of anti-obesity anti-diabetic approaches targeting GLP-1 signaling. While it is well-established that can exert influence through paracrine mechanisms, recent evidence suggests possible existence synaptic-like connections neurons, including those vagus nerve. In this study, using a reporter Phox2b-Cre-Tomato mouse model super-resolution confocal microscopy, we demonstrated vagal axons made apparent contacts with less than 0.5% cells. Moreover, immunohistochemistry combined microscopy revealed abundant post-synaptic density 95 (PSD-95) immunoreactivity within enteric plexus lower intestines C57/BL6 mice, virtually none in its mucosa. Lastly, utilizing RNAScope situ hybridization observed expressed generic markers secretory such as Snap25 Nefm, but neither synaptic Syn1 Nrxn2, nor glutamatergic Slc17a7. Through theoretical considerations critical review literature, concluded primarily communicate neurons rather contacts.
Language: Английский
Citations
3
Endocrinology, Journal Year: 2025, Volume and Issue: 166(4)
Published: Feb. 27, 2025
The gut microbiome, comprising bacteria, viruses, fungi, and bacteriophages, is one of the largest microbial ecosystems in human body plays a crucial role various physiological processes. This review explores interaction between microbiome enteroendocrine cells (EECs), specialized hormone-secreting within intestinal epithelium. EECs, which constitute less than 1% epithelial cells, are key regulators gut-brain communication, energy metabolism, motility, satiety. Recent evidence shows that microbiota directly influence EEC function, maturation, hormone secretion. For instance, commensal bacteria regulate production hormones like glucagon-like peptide 1 YY by modulating gene expression vesicle cycling EE cells. Additionally, metabolites such as short-chain fatty acids, derived from fermentation, play central regulating signaling pathways affect immune responses. Furthermore, interplay microbiota, metabolic diseases, obesity diabetes, examined, emphasizing microbiome's dual promoting health contributing to disease states. intricate relationship EECs offers new insights into potential therapeutic strategies for disorders.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 383 - 405
Published: Jan. 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 87 - 99
Published: Jan. 1, 2025
Language: Английский
Citations
0