Hippocampal remapping induced by new behavior is mediated by spatial context DOI Open Access
Samuel J. Levy, Michael E. Hasselmo

Published: June 8, 2023

The hippocampus plays a central role in episodic memory and spatial navigation. Hippocampal neurons form unique representational codes different environments, which may provide neural substrate for context that can trigger recall or enable performance of context-guided tasks. However, new learning often occurs familiar location, requiring location’s representation to be updated without erasing the previously existing representations adaptive again future. To study how affects acquired representation, we trained mice perform two plus maze tasks across nine days sequence Turn Right 1 – Go East 2 (three each), while used single-photon calcium imaging record activity hundreds dorsal CA1. One cohort performed entire experiment on same (One-Maze), second task (Two-Maze). We hypothesized CA1 One-Maze would exhibit more change patterns neuronal from than seen Two-Maze mice. Indeed, changes single unit population code were larger group. further show evidence utilize separate each environment. Finally, found remapping epochs did not involve an erasure first experience, as many both groups maintained Right-associated even after performing rule. These results demonstrate hippocampal remap response learning, is greater when experiences occur context, throughout information experience preserved.The self-localization consolidation into long term memory. place cells tracks animal’s location upcoming navigational decisions, providing, at ensemble level, physical location. Many studies have demonstrated existence divergent short time scales orthogonalize distinct learned simultaneously. Here, expand this knowledge using power track memories either environments over periods time. observe during rules environment environments. find behavioral rule previous causes significantly associated with observed does wholly destabilize rule, maintain specific important step forward understanding function by dramatically expanding temporal scale are measured.

Language: Английский

The language network as a natural kind within the broader landscape of the human brain DOI
Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(5), P. 289 - 312

Published: April 12, 2024

Language: Английский

Citations

71
Beyond simple laboratory studies: Developing sophisticated models to study rich behavior DOI Creative Commons
Antonella Maselli, Jeremy Gordon, Mattia Eluchans

et al.

Physics of Life Reviews, Journal Year: 2023, Volume and Issue: 46, P. 220 - 244

Published: July 13, 2023

Psychology and neuroscience are concerned with the study of behavior, internal cognitive processes, their neural foundations. However, most laboratory studies use constrained experimental settings that greatly limit range behaviors can be expressed. While focusing on restricted ensures methodological control, it risks impoverishing object study: by restricting we might miss key aspects function. In this article, argue psychology should increasingly adopt innovative designs, measurement methods, analysis techniques sophisticated computational models to probe rich, ecologically valid forms including social behavior. We discuss challenges studying rich behavior as well novel opportunities offered state-of-the-art methodologies new sensing technologies, highlight importance developing formal models. exemplify our arguments reviewing some recent streams research in psychology, other fields (e.g., sports analytics, ethology robotics) have addressed a model-based manner. hope these "success cases" will encourage psychologists neuroscientists extend toolbox behavioral – them processes they engage.

Language: Английский

Citations

43
Cortical gradients during naturalistic processing are hierarchical and modality-specific DOI Creative Commons
Ahmad Samara,

Jeffrey Eilbott,

Daniel S. Margulies

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 271, P. 120023 - 120023

Published: March 13, 2023

Understanding cortical topographic organization and how it supports complex perceptual cognitive processes is a fundamental question in neuroscience. Previous work has characterized functional gradients that demonstrate large-scale principles of organization. How these are modulated by rich ecological stimuli remains unknown. Here, we utilize naturalistic via movie-fMRI to assess macroscale We identify principal movie delineate separate hierarchies anchored sensorimotor, visual, auditory/language areas. At the opposite/heteromodal end perception-to-cognition axes, find more central role for frontoparietal network along with default network. Even across different stimuli, demonstrated good reliability, suggesting reflect brain state common conditions. The relative position areas within showed stronger numerous correlations behavioral scores compared resting gradients. Together, findings provide an ecologically valid representation underlying while active engaged multimodal, dynamic processing.

Language: Английский

Citations

22
The memory trace of an intrusive trauma-analog episode DOI Creative Commons
Malte Kobelt, Gerd T. Waldhauser,

Aleksandra Ewa Rupietta

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(8), P. 1657 - 1669.e5

Published: March 26, 2024

Intrusive memories are a core symptom of posttraumatic stress disorder. Compared with everyday events, they characterized by several seemingly contradictory features: intrusive contain distinct sensory and emotional details the traumatic event can be triggered various perceptually similar cues, but poorly integrated into conceptual memory. Here, we conduct exploratory whole-brain analyses to investigate neural representations trauma-analog experiences how reactivated during memory intrusions. We show that movies induce excessive processing generalized in areas decreased blood-oxygen-level-dependent (BOLD) responses highly conceptual/semantic areas. activate reactivate traces specific events anterior cingulate cortex. These findings provide first evidence could distort human brain, which may form basis for future confirmatory research on experiences.

Language: Английский

Citations

7
Unraveling the neural dichotomy of consensus and idiosyncratic experiences in short video viewing DOI
Mengjin Li,

Hong Huang,

Ke Zhou

et al.

Brain and Cognition, Journal Year: 2025, Volume and Issue: 184, P. 106260 - 106260

Published: Jan. 5, 2025

Language: Английский

Citations

0
Coordinated representations for naturalistic memory encoding and retrieval in hippocampal neural subspaces DOI Creative Commons
Dasom Kwon, Jungwoo Kim, Seng Bum Michael Yoo

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 14, 2025

Our naturalistic experiences are organized into memories through multiple processes, including novelty encoding, memory formation, and retrieval. However, the neural mechanisms coordinating these processes remain elusive. Using fMRI data acquired during movie viewing subsequent narrative recall, we examine hippocampal subspaces associated with distinct characterized their relationships. We quantify in character co-occurrences valence of relationships estimate event memorability. Within hippocampus, encoding each type exhibit partial overlap, overlapping align subspace involved Notably, following boundaries, states within inversely along a shared coding axis, predicting recall performance. This novelty-memorability alignment is selectively observed but not Finally, identified functional reflect intrinsic organization hippocampus. findings offer insights how hippocampus dynamically coordinates representations underlying retrieval at population level to transform ongoing enduring memories. In this study, authors show that aligns formation retrieval, components process its organisation.

Language: Английский

Citations

0
Narrative 'twist' shifts within-individual neural representations of dissociable story features DOI Creative Commons
Clara Sava‐Segal, Clare Grall, Emily S. Finn

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Given the same external input, one’s understanding of that input can differ based on internal contextual knowledge. Where and how does brain represent latent belief frameworks interact with incoming sensory information to shape subjective interpretations? In this study, participants listened auditory narrative twice, a plot twist in middle dramatically shifted their interpretations story. Using robust within-subject whole-brain approach, we leveraged shifts neural activity between two listens identify where are represented brain. We considered terms its hierarchical structure, examining global situation models subcomponents–namely, episodes characters–are represented, finding they rely partially distinct sets regions. Results suggest our brains narratives hierarchically, individual elements being dynamically updated as part changing information.

Language: Английский

Citations

0
Linguistic coupling between neural systems for speech production and comprehension during real-time dyadic conversations DOI Creative Commons
Zaid Zada, Samuel A. Nastase, Sebastian Speer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The core use of human language is communicating complex ideas from one mind to another in everyday conversations. In conversations, comprehension and production processes are intertwined, as speakers soon become listeners, listeners speakers. Nonetheless, the neural systems underlying these faculties typically studied isolation using paradigms that cannot fully engage our capacity for interactive communication. Here, we used an fMRI hyperscanning paradigm measure activity simultaneously pairs subjects engaged real-time, We contextual word embeddings a large model quantify linguistic coupling between within across individual brains. found highly overlapping network regions involved both spanning much cortical network. Our findings reveal shared representations extend beyond into areas associated with social cognition. Together, results suggest specialized speech perception align on common set features encoded broad

Language: Английский

Citations

0
Multimodality and Attention Increase Alignment in Natural Language Prediction Between Humans and Computational Models DOI Creative Commons
Viktor Kewenig, Andrew K. Lampinen, Samuel A. Nastase

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Abstract The potential of multimodal generative artificial intelligence (mAI) to replicate human grounded language understanding, including the pragmatic, context-rich aspects communication, remains be clarified. Humans are known use salient features, such as visual cues, facilitate processing upcoming words. Correspondingly, computational models can integrate and linguistic data using a attention mechanism assign next-word probabilities. To test whether these processes align, we tasked both participants (N = 200) well several state-of-the-art with evaluating predictability forthcoming words after viewing short audio-only or audio-visual clips speech. During task, model’s weights were recorded was indexed via eye tracking. Results show that estimates from humans aligned more closely scores generated vs. their unimodal counterparts. Furthermore, an doubled alignment judgments when context facilitated predictions. In cases, patches tracking significantly overlapped. Our results indicate improved modeling naturalistic in mAI does not merely depend on training diet but driven by multimodality combination attention-based architectures. alike leverage predictive constraints information attending relevant features input.

Language: Английский

Citations

3
Fast-timescale hippocampal processes bridge between slowly unfurling neocortical states during memory search DOI Creative Commons
Sebastian Michelmann, Patricia Dugan,

Werner Doyle

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Prior behavioral work showed that event structure plays a key role in our ability to mentally search through memories of continuous naturalistic experience. We hypothesized that, neurally, this mem- ory process involves division labor between slowly un- furling neocortical states representing knowledge and fast hippocampal-neocortical communication supports retrieval new information at transitions events. To test this, we tracked slow neural state-patterns sample ten patients under- going intracranial electroencephalography as they viewed movie then searched their structured in- terview. As answered questions ("after X, when does Y happen next?"), from movie-viewing were reinstated neocortex; during memory-search, unfurled forward di- rection. Moments state-transition marked by low-frequency power decreases cortex preceded hip- pocampus correlated with reinstatement. Connectivity-analysis revealed information-flow hippocampus underpinning state-transitions. Together, these results support hypothesis hippocampal processes bridge memory search.

Language: Английский

Citations

0