Individual variation in the functional lateralization of human ventral temporal cortex: Local competition and long-range coupling DOI Creative Commons
Nicholas M. Blauch, David C. Plaut, Raina Vin

et al.

Imaging Neuroscience, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 1, 2025

The ventral temporal cortex (VTC) of the human cerebrum is critically engaged in high-level vision. One intriguing aspect this region its functional lateralization, with neural responses to words being stronger left hemisphere, and faces right hemisphere; such patterns can be summarized a signed laterality index (LI), positive for leftward laterality. Converging evidence has suggested that word emerges couple efficiently left-lateralized frontotemporal language regions, but more mixed regarding sources lateralization face perception. Here, we use individual differences as tool test three theories VTC organization arising from (1) local competition between driven by long-range coupling processes, (2) other categories, (3) areas exhibiting social processing. First, an in-house MRI experiment, did not obtain negative correlation LIs selectivity relative object responses, find when using fixation baseline, challenging ideas driving rightward lateralization. We next examined broader LI interactions large-scale Human Connectome Project (HCP) dataset. Face were significantly anti-correlated, while body positively correlated, consistent idea generic representational cooperation may shape Last, assessed role development Within our substantial was evident text several nodes distributed text-processing circuit. In HCP data, both negatively correlated processing different subregions posterior lobe (PSL STSp, respectively). summary, no face-word VTC; instead, multiple lateralities within VTC, including Moreover, also influenced lobe, where become lateralized due language.

Language: Английский

Language is primarily a tool for communication rather than thought DOI
Evelina Fedorenko, Steven T. Piantadosi,

Edward Gibson

et al.

Nature, Journal Year: 2024, Volume and Issue: 630(8017), P. 575 - 586

Published: June 19, 2024

Language: Английский

Citations

40
A hierarchical atlas of the human cerebellum for functional precision mapping DOI Creative Commons
Caroline Nettekoven, Da Zhi, Ladan Shahshahani

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

Citations

20
High-level language brain regions process sublexical regularities DOI
Tamar I. Regev,

Hee So Kim,

Xuanyi Chen

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(3)

Published: March 1, 2024

Abstract A network of left frontal and temporal brain regions supports language processing. This “core” stores our knowledge words constructions as well constraints on how those combine to form sentences. However, linguistic additionally includes information about phonemes they phonemic clusters, syllables, words. Are phoneme combinatorics also represented in these regions? Across five functional magnetic resonance imaging experiments, we investigated the sensitivity high-level processing sublexical regularities by examining responses diverse nonwords—sequences that do not constitute real (e.g. punes, silory, flope). We establish robust visually (experiment 1a, n = 605) auditorily (experiments 1b, 12, 1c, 13) presented nonwords. In experiment 2 (n 16), find stronger nonwords are more well-formed, i.e. obey phoneme-combinatorial English. Finally, 3 14), provide suggestive evidence experiments 1 due activation share some phonology with The results suggest stored processed within same fronto-temporal lexical syntactic processes.

Language: Английский

Citations

17
Distributed Sensitivity to Syntax and Semantics throughout the Language Network DOI Creative Commons
Cory Shain, Hope Kean, Colton Casto

et al.

Journal of Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 36(7), P. 1427 - 1471

Published: Jan. 1, 2024

Abstract Human language is expressive because it compositional: The meaning of a sentence (semantics) can be inferred from its structure (syntax). It commonly believed that syntax and semantics are processed by distinct brain regions. Here, we revisit this claim using precision fMRI methods to capture separation or overlap function in the brains individual participants. Contrary prior claims, find distributed sensitivity both throughout broad frontotemporal network. Our results join growing body evidence for an integrated network human within which internal specialization primarily matter degree rather than kind, contrast with influential proposals advocate different areas types linguistic functions.

Language: Английский

Citations

14
Functional characterization of the language network of polyglots and hyperpolyglots with precision fMRI DOI Open Access
Saima Malik-Moraleda, Olessia Jouravlev, Maya Taliaferro

et al.

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(3)

Published: March 1, 2024

Abstract How do polyglots—individuals who speak five or more languages—process their languages, and what can this population tell us about the language system? Using fMRI, we identified network in each of 34 polyglots (including 16 hyperpolyglots with knowledge 10+ languages) examined its response to native language, non-native languages varying proficiency, unfamiliar languages. All conditions engaged all areas relative a control condition. Languages that participants rated as higher proficiency elicited stronger responses, except for which similar lower than proficiency. Furthermore, were typologically related participants’ high-to-moderate-proficiency unrelated The results suggest network’s magnitude scales degree engagement linguistic computations (e.g. lexical access syntactic-structure building). We also replicated prior finding weaker responses non-polyglot bilinguals. These contribute our understanding how multiple coexist within single brain provide new evidence responds strongly stimuli fully engage computations.

Language: Английский

Citations

10
Continuous theta-burst stimulation demonstrates language-network-specific causal effects on syntactic processing DOI Creative Commons
Chenyang Gao, Junjie Wu,

Yao Cheng

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 306, P. 121014 - 121014

Published: Jan. 9, 2025

Hierarchical syntactic structure processing is proposed to be at the core of human language faculty. Syntactic supported by left fronto-temporal network, including a area in inferior frontal gyrus as well its interaction with posterior temporal lobe (i.e., "IFG + pTL"). Moreover, during complex processes, IFG also interacts executive control regions, such superior parietal lobule (SPL). However, functional relevance these network interactions largely unclear. In particular, it remains demonstrated whether plays specific causal role comparatively challenging separable from between and other general cognitive regions SPL" present study). The study was designed address this question. Thirty healthy adult Chinese native speakers underwent four continuous theta-burst stimulation (cTBS) sessions: over IFG, pTL, SPL, sham irrelevant region pseudo-randomized order. each session, participants were required label categories jabberwocky sequences retaining real function words (e.g., "ムウ" labeled verb phrase (VP): "[

Language: Английский

Citations

2
Animal models of the human brain: Successes, limitations, and alternatives DOI
Nancy Kanwisher

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 90, P. 102969 - 102969

Published: Feb. 1, 2025

Language: Английский

Citations

2
Frontotemporal dementia. How to deal with its diagnostic complexity? DOI Creative Commons
Annibale Antonioni,

Emanuela Maria Raho,

Enrico Granieri

et al.

Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Frontotemporal dementia (FTD) encompasses a group of heterogeneous neurodegenerative disorders. Aside from genetic cases, its diagnosis is challenging, particularly in the early stages when symptoms are ambiguous, and structural neuroimaging does not reveal characteristic patterns. The authors performed comprehensive literature search through MEDLINE, Scopus, Web Science databases to gather evidence aid diagnostic process for suspected FTD patients, phases, even sporadic ranging established promising tools. Blood-based biomarkers might help identify very neuropathological guide further evaluations. Subsequently, neurophysiological measures reflecting functional changes cortical excitatory/inhibitory circuits, along with assessing brain network, connectivity, metabolism, perfusion alterations, could detect specific associated decades before symptom onset. As advances, cognitive-behavioral profiles atrophy patterns emerge, distinguishing subtypes. Emerging disease-modifying therapies require patient enrollment. Therefore, paradigm shift needed - relying on typical cognitive advanced cases widely applicable biomarkers, primarily fluid and, subsequently, where appropriate. Additionally, exploring subjective complaints behavioral detected by home-based technologies be crucial diagnosis.

Language: Английский

Citations

2
Asymmetric sampling in time: evidence and perspectives DOI Creative Commons
Chantal Oderbolz, David Poeppel, Martin Meyer

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 171, P. 106082 - 106082

Published: Feb. 24, 2025

Language: Английский

Citations

2
A hierarchical atlas of the human cerebellum for functional precision mapping DOI Creative Commons
Caroline Nettekoven, Da Zhi, Ladan Shahshahani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 14, 2023

ABSTRACT The human cerebellum is activated by a wide variety of cognitive and motor tasks. Previous functional atlases have relied on single task-based or resting-state fMRI datasets. Here, we present atlas that integrates information from 7 large-scale datasets, outperforming existing group atlasses. new has three further advantages: First, the allows for precision mapping in individuals: integration probabilistic with an individual localizer scan results marked improvement prediction boundaries. Second, provide both asymmetric symmetric versions atlas. version, which obtained constraining boundaries to be same across hemispheres, especially useful studying lateralization. Finally, regions are hierarchically organized 3 levels, allowing analyses at appropriate level granularity. Overall, important resource study interdigitated organization health disease.

Language: Английский

Citations

23