Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs)

One Health, Journal Year: 2024, Volume and Issue: 18, P. 100734 - 100734

Published: April 20, 2024

Non-communicable diseases (NCDs) pose a global health challenge, leading to substantial morbidity, mortality, and economic strain. Our review underscores the escalating incidence of NCDs worldwide highlights potential regenerative agriculture (RA) products in mitigating these diseases. We also explore efficacy dietary interventions NCD management prevention, emphasizing superiority plant-based diets over those high processed foods red meat. Examining role gut microbiome various diseases, including liver disorders, allergies, metabolic syndrome, inflammatory bowel disease, colon cancer, we find compelling evidence implicating its influence on disease development. Notably, modifications can positively affect microbiome, fostering symbiotic relationship with host making this critical strategy prevention treatment. Investigating agricultural practices, identify parallels between soil/plant human studies, suggesting crucial link soil health, plant- animal-derived food quality, well-being. Conventional/Industrial (IA) characterized part by use chemical inputs, have adverse effects diversity, ecosystems. In contrast, RA prioritizes through natural processes, includes avoiding synthetic crop rotation, integrating livestock. Emerging suggests that from systems surpasses IA-produced quality nutritional value. Recognizing interconnection human, plant, microbiomes, promoting RA-produced emerges as improve environmental sustainability. By climate change impacts carbon sequestration water cycling, offers dual benefits for planetary Emphasizing pivotal diet practices combating addressing concerns, adoption regional becomes imperative. Increasing integration into local enhance availability, affordability while safeguarding planet's future.

Language: Английский

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Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 124, P. 108534 - 108534

Published: Jan. 6, 2024

Language: Английский

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Role of TMEM230 in the Aberrant Glycosylation in Human Autoimmunity and Cancer

Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 1, 2025

ABSTRACT Alterations in glycoconjugate profiles are thought to promote changes cell‐to‐cell and cell‐to‐intracellular extracellular scaffold interactions human disease. The nearly unlimited number of “glycoforms” that may exist nature difficult study due glycosylation modifications being associated with non‐genome coded posttranscription post‐translation processes. Specific products generated by dependent on concentration sub‐cellular locations glycan synthesis processing enzymes. An indirect “high‐throughput” approach is characterize enzymes (hydrolases transferases) single cell sequencing all types tissue diseases. We previously identified TMEM230 as an endoplasmic reticulum (ER) protein regulates NOTCH glycoprotein receptor ligand signaling zebrafish blood vessel formation destructive remodeling capacities diverse including fibroblast, phagocytic immune system cells patients cancer or granulomatous systemic vasculitis autoimmune disorder. represents a paradigm mediated signal transduction supports the role modifications. ER initiates earliest steps synthesis, sorting, trafficking. As remodeling, Notch hallmarks disorders, we investigated whether aberrant expression was also rheumatoid arthritis (RA). In this current study, analysis supported downregulated synovial RA while were predominantly upregulated. contrast, upregulated high‐grade compared low‐grade gliomas it N‐linked (GlcNAc), glycosaminoglycan expression. Our collective results support glycan/glycoconjugate aggressive gliomas. therefore be therapeutic target marker for clinical treatment induced autoimmunity disorders cancer.

Language: Английский

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The Evolution, Assembly, and Dynamics of Marine Holobionts

Annual Review of Marine Science, Journal Year: 2023, Volume and Issue: 16(1), P. 443 - 466

Published: Aug. 8, 2023

The holobiont concept (i.e., multiple living beings in close symbiosis with one another and functioning as a unit) is revolutionizing our understanding of biology, especially marine systems. earliest was likely syntrophic partnership at least two prokaryotic members. Since then, has enabled organisms to conquer all ocean habitats through the formation holobionts wide spectrum complexities. However, most scientific inquiries have focused on isolated their adaptations specific environments. In this review, we attempt illustrate why perspective-specifically, study how numerous form discrete ecological unit symbiosis-will be more impactful strategy advance ecology evolution life. We argue that approach instrumental addressing threats biodiversity posed by current global environmental crisis.

Language: Английский

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The Sphinx and the egg: Evolutionary enigmas of the (glyco)sphingolipid biosynthetic pathway

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2024, Volume and Issue: 1869(3), P. 159462 - 159462

Published: Feb. 2, 2024

Language: Английский

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Mitochondria: fundamental characteristics, challenges, and impact on aging

Biogerontology, Journal Year: 2024, Volume and Issue: 25(6), P. 923 - 941

Published: Aug. 28, 2024

Language: Английский

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Low-Dose Non-Targeted Effects and Mitochondrial Control

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11460 - 11460

Published: July 14, 2023

Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation (IR) phenomenon. Recently, regarding long distant abscopal also observed at high doses of IR) relevant to antitumor therapy. IR is inducing NTE involving intracellular and extracellular signaling, which may lead short-ranging bystander long-ranging signaling effects. Internal “spontaneous” cellular stress mostly due metabolic oxidative mitochondrial energy production (ATP) through phosphorylation and/or anaerobic pathways accompanied by the leakage O2− other radicals from mitochondria during normal or increased requirements dysfunction. Among external stressors, has shown very rapidly perturb functions, leading supply demands ROS/NOS production. Depending on dose, this affects all types cell constituents, including DNA, RNA, amino acids, proteins, membranes, perturbing inner organization function, forcing cells reorganize metabolism network organelles. The reorganization implies cytoplasmic-nuclear shuttling important activation autophagy, mitophagy, well induction cycle arrest, DNA repair, apoptosis, senescence. It includes reprogramming genetic epigenetic control expression genes proteins in order ensure tissue survival. At low IR, directly irradiated already exert non-targeted release molecular mediators, such radicals, cytokines, fragments, small RNAs, (sometimes form vehicles exosomes), can induce damage unirradiated neighboring (abscopal) immune responses. Such are contributing phenomena, hormesis, adaptive responses, hypersensitivity, genomic instability, they promoting suppression cells. All these parts main defense systems tissues, IR-induced innate present review focused prominent role processes, determinants survival anti-tumor RT.

Language: Английский

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Reconstructing the last common ancestor of all eukaryotes

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(11), P. e3002917 - e3002917

Published: Nov. 25, 2024

Understanding the origin of eukaryotic cells is one most difficult problems in all biology. A key challenge relevant to question eukaryogenesis reconstructing gene repertoire last common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture early cellular complexity requires provision analytical resources and a commitment sharing. Here, we summarise progress towards understanding biology LECA outline community approach inferring its wider repertoire. Once assembled, robust set will be useful tool for evaluating alternative hypotheses about eukaryotes evolution traits descendant lineages, with relevance diverse fields such as cell biology, microbial ecology, biotechnology, agriculture, medicine. In this Consensus View, put forth status quo agreed path forward reconstruct LECA's content.

Language: Английский

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Archaea and the Tree of Life

Published: Jan. 24, 2025

The rapid development of research on archaea by biochemists in the 1980s led to a completely unexpected discovery. Alongside characteristics unique them, such as structure their lipids, exhibited numerous traits that brought them closer eukaryotes. In 1990s, Karl Stetter redesigned Carl Woese's universal tree life, highlighting lines leading organisms whose optimal growth temperatures exceed 80 degree Celsius. Starting 2000s, genome sequencing across three domains life enabled construction phylogenetic trees based universally conserved proteins. context 2D hypothesis, eukaryotic proteins distribution is limited certain groups are called ESPs (eukaryotic signature proteins) because they suggest an evolutionary proximity between these and hypothesis Asgard our ancestors has gained popularity it motivated teams search within for evidence could support this hypothesis.

Language: Английский

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Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections

Open Biology, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

Glycolysis, present in most organisms, is evolutionarily one of the oldest metabolic pathways. It has great relevance at a physiological level because it responsible for generating ATP cell through conversion glucose into pyruvate and reducing nicotinamide adenine dinucleotide (NADH) (that may be fed electron chain mitochondria to produce additional by oxidative phosphorylation), as well producing intermediates that can serve substrates other processes. Glycolysis takes place 10 consecutive chemical reactions, each which catalysed specific enzyme. Although energy transduction metabolism main function this pathway, involvement virulence, growth, pathogen–host interactions, immunomodulation adaptation environmental conditions are functions attributed pathway. In humans, where glycolysis occurs mainly cytosol, mislocalization some glycolytic enzymes various subcellular locations, alterations their expression regulation, been associated with development progression diseases. review, we describe role pathogenesis diseases clinical interest. addition, potential these targets drug use diagnostic prognostic markers pathologies also discussed.

Language: Английский

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