Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions DOI Creative Commons
Soumilee Chaudhuri, Minyoung Cho,

Julia C. Stumpff

et al.

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 29, 2025

Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative that marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances high throughput single-cell transcriptomics technology have enabled study of human vasculature at an unprecedented depth. Additionally, understudied niche cerebrovascular cells, such as endothelial mural their subtypes been scrutinized for understanding cellular transcriptional heterogeneity AD. Here, we provide overview rich signatures derived from recent single-nucleus transcriptomic studies vascular cells implications targeted therapy We conducted in-depth literature search using Medline Covidence to identify pertinent AD utilized technologies post-mortem tissue focusing on differences cell types cognitively normal older adults. also discuss impaired crosstalk between neuroglial units, well astrocytes contextualize findings distinct smooth muscle fibroblasts, pericytes highlight pathways potential therapeutic interventions concerted multi-omic effort with spatial technology, neuroimaging, neuropathology. Overall, detailed account crucial unit. Graphical Endothelial mediate dysregulated cell-cell interactions The unit (NVU) composed various types, including (pericytes, cells), fibroblast neurons, microglia, astrocytes. Dysregulated involve multiple pathways, notably immune responses, angiogenesis common both cells. involving neuroinflammation amyloid clearance are prominent while exhibit related growth factors, cytoskeletal remodeling synaptic function. In addition, within NVU gliovascular (GVU) altered AD, communication evident, increased pericytes, decreased astrocytes, neurons. Figure created BioRender.com. Abbreviations: Alzheimer's disease; NVU, Neurovascular unit; CNS, Central Nervous System.

Language: Английский

Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases DOI Creative Commons
Rosanna Avola,

Alessandro Giuseppe Furnari,

Adriana Carol Eleonora Graziano

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 178 - 178

Published: Jan. 31, 2024

Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark diseases and potential benefits essential oils counteracting neuroinflammation oxidative stress, thereby offering novel strategy managing mitigating impact disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with myriad health benefits. exhibit robust antioxidant activity, serving scavengers free radicals contributing to cellular defense against stress. Furthermore, showcase anti-inflammatory properties, modulating immune responses inflammatory processes implicated chronic diseases. The intricate by which phytomolecules exert their effects were explored, shedding light on multifaceted properties. Notably, we discussed ability modulate diverse pathways crucial maintaining homeostasis suppressing responses, capacity rescue cognitive deficits observed preclinical models neurotoxicity

Language: Английский

Citations

4
Loss of glymphatic homeostasis in heart failure DOI Creative Commons
Marios Kritsilis, Lotte Vanherle, Marko Rosenholm

et al.

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Heart failure (HF) is associated with progressive reduction in cerebral blood flow (CBF) and neurodegenerative changes leading to cognitive decline. The glymphatic system crucial for the brain's waste removal, its dysfunction linked neurodegeneration. In this study, we used a mouse model of HF, induced by myocardial infarction (MI), investigate effects HF reduced ejection fraction on brain’s function. Using dynamic contrast-enhanced MRI high-resolution fluorescence microscopy, found increased solute influx from CSF spaces brain, i.e. influx, at 12 weeks post MI. Two-photon microscopy revealed that arterial pulsatility, major driver system, was potentiated timepoint, could explain increase influx. However, clearance proteins brain parenchyma did not proportionately while relative volume MI, suggesting dysregulation fluid dynamics. Additionally, our results showed correlation between CBF. These findings highlight role CBF as key regulator involvement development disorders This study paves way future investigations into cardiovascular diseases mechanisms, which may provide novel insights prevention treatment

Language: Английский

Citations

4
Brain tissue integrity in neuromyelitis optica spectrum disorder through T1-w/T2-w ratio, MTR and DTI DOI
Mateus Boaventura de Oliveira, Diego Cardoso Fragoso,

Isabella Avolio

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(2)

Published: Jan. 17, 2025

Language: Английский

Citations

0
Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain DOI Creative Commons
Yuran Zhu, Junqing Zhu,

C. M. Ni

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Tracer imaging has been instrumental in mapping the brain's solute transport pathways facilitated by cerebrospinal fluid (CSF) flow. However, impact of tracer infusion parameters on CSF flow remains incompletely understood. This study evaluated influence location, rate, and anesthetic regimens using dynamic contrast-enhanced MRI with Gd-DTPA as a tracer. Infusion rate effects were assessed administering into cisterna magna (ICM) at two rates under isoflurane anesthesia. Anesthetic comparing patterns between ketamine/xylazine (K/X) anesthesia slower rate. was also examined after lateral ventricle (ICV) infusion, primary site production. The results demonstrate that, besides anesthesia, both location substantially affected within brain. ICV led to rapid, extensive deep brain regions, while ICM resulted more pronounced dorsal regions. Cross-correlation hierarchical clustering analyses region-specific signal time courses revealed that along periarterial spaces, favored across ventricular-parenchymal interface. These findings underscore importance experimental conditions influencing kinetics spatial distribution

Language: Английский

Citations

0
Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions DOI Creative Commons
Soumilee Chaudhuri, Minyoung Cho,

Julia C. Stumpff

et al.

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 29, 2025

Abstract Alzheimer’s disease (AD) is a debilitating neurodegenerative that marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances high throughput single-cell transcriptomics technology have enabled study of human vasculature at an unprecedented depth. Additionally, understudied niche cerebrovascular cells, such as endothelial mural their subtypes been scrutinized for understanding cellular transcriptional heterogeneity AD. Here, we provide overview rich signatures derived from recent single-nucleus transcriptomic studies vascular cells implications targeted therapy We conducted in-depth literature search using Medline Covidence to identify pertinent AD utilized technologies post-mortem tissue focusing on differences cell types cognitively normal older adults. also discuss impaired crosstalk between neuroglial units, well astrocytes contextualize findings distinct smooth muscle fibroblasts, pericytes highlight pathways potential therapeutic interventions concerted multi-omic effort with spatial technology, neuroimaging, neuropathology. Overall, detailed account crucial unit. Graphical Endothelial mediate dysregulated cell-cell interactions The unit (NVU) composed various types, including (pericytes, cells), fibroblast neurons, microglia, astrocytes. Dysregulated involve multiple pathways, notably immune responses, angiogenesis common both cells. involving neuroinflammation amyloid clearance are prominent while exhibit related growth factors, cytoskeletal remodeling synaptic function. In addition, within NVU gliovascular (GVU) altered AD, communication evident, increased pericytes, decreased astrocytes, neurons. Figure created BioRender.com. Abbreviations: Alzheimer's disease; NVU, Neurovascular unit; CNS, Central Nervous System.

Language: Английский

Citations

0