The dorsal thalamic lateral geniculate nucleus is required for visual control of head direction cell firing direction in rats DOI Creative Commons
James S Street, Kathryn J. Jeffery

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Head direction (HD) neurons, signalling facing direction, generate a signal that is primarily anchored to the outside world by visual inputs. We investigated route for landmark information into HD system in rats. There are two candidates: an evolutionarily older, larger subcortical retino‐tectal pathway and more recently evolved, smaller cortical retino‐geniculo‐striate pathway. disrupted lesioning dorsal lateral geniculate thalamic nuclei bilaterally, recorded cells postsubicular cortex as rats foraged visual‐cue‐controlled enclosure. In lesioned we found expected number of cells. Although directional tuning curves were broader across trial, this was attributable increased instability otherwise normal‐width curves. Tuning also poorly responsive polarizing landmarks did not distinguish cues based on their pattern. Thus, crucial generation underlying, tightly tuned but does provide main vision‐based anchoring world, even when high contrast low detail. image Key points indicate head, using directions. rats, whether routed through thalamus or arrives via superior colliculus, which phylogenetically older (in rodents) nucleus (dLGN) responsiveness cues. had normal curves, these slightly unstable during trial. Most notably, dLGN‐lesioned animals showed little ability highly distinct none similar These results suggest processing mammals requires geniculo‐cortical pathway, raises questions about how appeared evolution.

Language: Английский

Genetically defined neuron types underlying visuomotor transformation in the superior colliculus DOI
Jianhua Cang, Chen Chen,

Chuiwen Li

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

Citations

6
Involvement of superior colliculus in complex figure detection of mice DOI Creative Commons
J. Leonie Cazemier,

Robin Haak,

TK Loan Tran

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 25, 2024

Object detection is an essential function of the visual system. Although cortex plays important role in object detection, superior colliculus can support when ablated or silenced. Moreover, it has been shown that superficial layers mouse SC (sSC) encode features complex objects, and this code not inherited from primary cortex. This suggests sSC may provide a significant contribution to vision. Here, we use optogenetics show involved figure based on differences contrast, orientation, phase. Additionally, our neural recordings sSC, image elements belong elicit stronger activity than those same they are part background. The discriminability higher for correct trials incorrect trials. Our results new insight into behavioral relevance processing takes place sSC.

Language: Английский

Citations

5
Neural dynamics in superior colliculus of freely moving mice DOI Creative Commons
Shelby L. Sharp, Jhoseph Shin, Dylan M. Martins

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Vision is an active process that depends on head and eye movements to explore the visual environment. Superior colliculus (SC) known for its role in generating these movements, as well processing information, but has not been studied extensively during free movement complex environments. To determine impact of vision, we recorded neural activity across depth SC while simultaneously recording position. We find superficial (sSC) neurons respond input following gaze-shifting saccadic whereas deep (dSC) themselves, demonstrated by their sustained response darkness. Additionally, motor responses dSC are more correlated rather than movements. Furthermore, compared sSC gaze shift primary cortex (V1), finding similarities key types, although temporal sequences shifts differ between regions. Our results demonstrate distinct differences V1 highlighting various roles plays vision. Highlights depths superior freely moving mice measuring Neurons mouse strongly shifts, layers. primarily a movement. generally represent movement, independent input. While share with there unique profiles suggest

Language: Английский

Citations

0
Rapid integration of face detection and task set in visually guided reaching DOI Creative Commons
David Y. Mekhaiel, Melvyn A. Goodale, Brian D. Corneil

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(6), P. 5328 - 5347

Published: Aug. 19, 2024

Abstract The superior colliculus (SC) has been increasingly implicated in the rapid processing of evolutionarily relevant stimuli like faces, but behavioural relevance such is unclear. SC also generation express visuomotor responses (EVR), which are very short‐latency (~80 ms) bursts muscle activity time‐locked to visual target presentation. These observations led us investigate influence faces on EVRs. We recorded upper limb from healthy participants as they reached toward targets presence a distractor. In some experiments, were used stimuli. Across blocks trials, we varied instruction stimulus served or Doing so allowed assess impact recruitment given identical found that uniquely modulated tasks involving high‐contrast promoting reaches away face depending instruction. Follow‐up experiments confirmed phenomenon required highly salient repeated and was not observed non‐facial nor expressing different affects. This study extends hypothesis mediates EVR by demonstrating at short latencies precede cortical for perception. Our results constitute direct evidence detection brainstem, implicate role top‐down pre‐setting task context.

Language: Английский

Citations

2
The dorsal thalamic lateral geniculate nucleus is required for visual control of head direction cell firing direction in rats DOI Creative Commons
James S Street, Kathryn J. Jeffery

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Head direction (HD) neurons, signalling facing direction, generate a signal that is primarily anchored to the outside world by visual inputs. We investigated route for landmark information into HD system in rats. There are two candidates: an evolutionarily older, larger subcortical retino‐tectal pathway and more recently evolved, smaller cortical retino‐geniculo‐striate pathway. disrupted lesioning dorsal lateral geniculate thalamic nuclei bilaterally, recorded cells postsubicular cortex as rats foraged visual‐cue‐controlled enclosure. In lesioned we found expected number of cells. Although directional tuning curves were broader across trial, this was attributable increased instability otherwise normal‐width curves. Tuning also poorly responsive polarizing landmarks did not distinguish cues based on their pattern. Thus, crucial generation underlying, tightly tuned but does provide main vision‐based anchoring world, even when high contrast low detail. image Key points indicate head, using directions. rats, whether routed through thalamus or arrives via superior colliculus, which phylogenetically older (in rodents) nucleus (dLGN) responsiveness cues. had normal curves, these slightly unstable during trial. Most notably, dLGN‐lesioned animals showed little ability highly distinct none similar These results suggest processing mammals requires geniculo‐cortical pathway, raises questions about how appeared evolution.

Language: Английский

Citations

2