Caring for and Working With Research Animals in Toxicology DOI
Patricia V. Turner, Elizabeth A. Nunamaker

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Sex contextualism in laboratory research: Enhancing rigor and precision in the study of sex-related variables DOI Creative Commons
Madeleine Pape, Miriam Miyagi, Stacey A. Ritz

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(6), P. 1316 - 1326

Published: March 1, 2024

Language: Английский

Citations

35
From means to meaning in the study of sex/gender differences and similarities DOI Creative Commons
Carles Sanchis‐Segura, Rand R. Wilcox

Frontiers in Neuroendocrinology, Journal Year: 2024, Volume and Issue: 73, P. 101133 - 101133

Published: April 1, 2024

The incorporation of sex and gender (S/G) related factors is commonly acknowledged as a necessary step to advance towards more personalized diagnoses treatments for somatic, psychiatric, neurological diseases. Until now, most attempts integrate S/G-related have been reduced identifying average differences between females males in behavioral/ biological variables. present commentary questions this traditional approach by highlighting three main sets limitations: 1) Issues stemming from the use classic parametric methods compare means; 2) challenges ability means accurately represent data within groups groups; 3) mean comparisons impose results' binarization binary theoretical framework that precludes advancing precision medicine. Alternative free these limitations are also discussed. We hope arguments will contribute reflecting on how research S/G conducted could be improved.

Language: Английский

Citations

7
Behavioral neuroscience’s inevitable SABV growing pains DOI
Rebecca M. Shansky

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(9), P. 669 - 676

Published: July 20, 2024

Language: Английский

Citations

7
No compelling evidence of sex differences in brain maturation during COVID-19 lockdowns when the sexes are compared statistically DOI Creative Commons
Andrew W. Brown, Simon Chung,

Timothy Richard Koscik

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(14)

Published: April 1, 2025

Language: Английский

Citations

1
The Sex Inclusive Research Framework to address sex bias in preclinical research proposals DOI Creative Commons
Natasha A. Karp,

Manuel Berdoy,

Kelly Gray

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 22, 2025

An interactive Sex Inclusive Research Framework (SIRF) supports the evaluation of in vivo and ex research proposals to address risk sex bias preclinical research. The framework delivers a traffic light classification, indicating whether proposal is appropriate, risky, or insufficient with regard inclusion. This tool designed for use by researchers, (animal) ethical review boards, funders generate rigorous reproducible assessment inclusion at level, thus helping resolve embedded

Language: Английский

Citations

1
Sex differences in the rodent medial prefrontal cortex – What Do and Don't we know? DOI
Mikaela A. Laine, Eliza M. Greiner, Rebecca M. Shansky

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 248, P. 109867 - 109867

Published: Feb. 20, 2024

Language: Английский

Citations

6
Leveraging research into sex differences and steroid hormones to improve brain health DOI
Bonnie H. Lee,

Rand S. Eid,

Travis E. Hodges

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

Citations

6
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses DOI Creative Commons
Annika Gompers,

Madeline T. Olivier,

Donna L. Maney

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 3, 2024

Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effective training in how to account sex, some cases gender, biomedical studies. Here, we evaluated three sets publicly available online materials on this topic: (1) Integrating Sex & Gender Health Research from Canadian Institutes (CIHR); (2) as a Biological Variable: A Primer United States National (NIH); (3) The Dimension Biomedical Research, developed part "Leading Innovative measures reach gender Balance Activities" (LIBRA) European Commission. We reviewed each course with respect their coverage What is required by policy; Rationale Handling concepts "sex" "gender;" (4) design analysis; (5) Interpreting reporting data. All courses discussed importance including better generalize results, discover potential sex differences, tailor treatments men women. entangled nature operationalization downsides focusing more than other sources variation were minimally discussed. Notably, all explicitly endorsed invalid analytical approaches that produce bias toward false positive discoveries difference. Our analysis suggests revised or new incorporate four major topics: precise risks over-emphasis category, recognition complex entangled, rigorous study data analysis.

Language: Английский

Citations

5
A novel discovery platform for targeted drug repurposing: application for psychiatric disorders DOI
Michael Berk, Jee Hyun Kim, Lana J. Williams

et al.

The Lancet Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Navigating the paradigm shift of sex inclusive preclinical research and lessons learnt DOI Creative Commons
Natasha A. Karp

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 29, 2025

Language: Английский

Citations

0