2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(4), P. 546 - 708

Published: July 29, 2024

Language: Английский

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Evolutionary changes in metabolic dysfunction-associated steatotic liver disease and risk of hepatocellular carcinoma: A nationwide cohort study

Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: 30(3), P. 487 - 499

Published: May 7, 2024

Background/Aims: To determine the association between evolutionary changes in metabolic dysfunction-associated steatotic liver disease (MASLD) status and risk of hepatocellular carcinoma (HCC) a nationwide population-based cohort.Methods: Information on study participants was derived from Korea National Health Insurance Service database. The population consisted 5,080,410 who underwent two consecutive biennial health screenings 2009 2012. All were followed up until HCC, death, or 31 December 2020. MASLD status, as assessed by fatty index cardiometabolic factors, including persistent non-MASLD, resolved MASLD, incident with HCC evaluated using multivariable-adjusted Cox proportional hazards regression.Results: Among 39,910,331 person-years follow-up, 4,801 developed HCC. incidence resolved, incident, approximately 2.2-, 2.3-, 4.7-fold higher, respectively, than that those non-MASLD among Korean adult population. When stratifying according to change (adjusted hazard ratio [aHR], 2.94; 95% confidence interval [CI], 2.68–3.21; P<0.001), (aHR, 1.85; CI, 1.63–2.10; 1.33; 1.18–1.50; P<0.001) had an increased compared non-MASLD.Conclusions: associated differential independent factors concomitant medications, providing additional information stratification patients MASLD.

Language: Английский

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Dyslipidemia Fact Sheet in South Korea, 2022

Diabetes & Metabolism Journal, Journal Year: 2023, Volume and Issue: 47(5), P. 632 - 642

Published: Aug. 2, 2023

This study aimed to investigate the prevalence and status of dyslipidemia management among South Korean adults, as performed by Society Lipid Atherosclerosis under name Dyslipidemia Fact Sheet 2022.

Language: Английский

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Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(3), P. 327 - 339

Published: Feb. 4, 2024

It has been generally accepted that insulin resistance (IR) and reduced secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, persistence systemic inflammation caused by obesity associated threat lipotoxicity increase risk T2DM. particular, main cause IR is subjects with T2DM have a higher body mass index (BMI) than normal according recent studies. The prevalence increased increasing BMI during past three decades. According studies, homeostatic model assessment was compared 1990s. Rising in Korea contributed development IR, non-alcoholic fatty liver disease cutting this vicious cycle important. My colleagues I investigated pathogenic mechanism on theme through clinical experimental studies over 20 years herein, would like summarize some our deep gratitude for receiving prestigious 2023 Sulwon Award.

Language: Английский

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Risk for Esophageal Cancer Based on Lifestyle Factors–Smoking, Alcohol Consumption, and Body Mass Index: Insight from a South Korean Population Study in a Low-Incidence Area

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(22), P. 7086 - 7086

Published: Nov. 14, 2023

Esophageal cancer constitutes a global public health challenge. However, South Korean population-specific information on the association of lifestyle (smoking, alcohol consumption, and obesity status) with esophageal risk is sparse. This nested case–control study analyzed national screening cohort data (2002–2019) 1114 patients 4456 controls (1:4 propensity-score matched for sex, age, income, residential region). Conditional unconditional logistic regression analyses, after adjustment multiple covariates, determined effects factors risk. Smoking consumption increased (adjusted odds ratio [95% confidence interval]: 1.37 [1.15–1.63] 1.89 [1.60–2.23], respectively). Overweight (body mass index [BMI] ≥ 23 to <25 kg/m2), obese I (BMI 25 <30 or II 30 kg/m2) categories had reduced (0.76 [0.62–0.92], 0.59 [0.48–0.72], 0.47 [0.26–0.85], In subgroup incident smoking persisted, particularly in men those aged ≥55 years, whereas higher BMI scores remained consistently associated likelihood across all age groups, both sexes, users current smokers. Underweight smokers exhibited propensity cancer. conclusion, drinking may potentially increase risk, weight maintenance, kg/m2, decrease population. Lifestyle modification specific subgroups be potential strategy preventing

Language: Английский

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Sleep Duration and the Risk of Type 2 Diabetes: A Community-Based Cohort Study with a 16-Year Follow-up

Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 38(1), P. 146 - 155

Published: Feb. 6, 2023

We aimed to investigate the moderating effects of obesity, age, and sex on association between sleep duration development diabetes in Asians.We analyzed data from a cohort Korean Genome Epidemiology Study conducted 2001 2020. After excluding shift workers those with at baseline, 7,407 participants were stratified into three groups according duration: ≤5 hours/night, >5 7 hours/night (reference), >7 hours/night. The Cox proportional hazards analyses used calculate hazard ratios (HRs) 95% confidence intervals (CIs) for incident type 2 mellitus (T2DM). Subgroup performed sex.During 16 years follow-up, 2,024 cases T2DM identified. Individuals who slept h/night had higher risk than reference group (HR, 1.17; CI, 1.02 1.33). subgroup analysis observed valid interaction only obesity. A was non-obese individuals, men, aged <60 years, obese individuals (HRs 1.34 [95% 1.11 1.61], 1.22 1 1.49], 1.18 1.01 1.39], respectively).This study confirmed effect deprivation throughout 16-year follow-up period. This impact confined or young men. significant

Language: Английский

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Associations of Ultra-Processed Food Intake with Body Fat and Skeletal Muscle Mass by Sociodemographic Factors

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(4), P. 780 - 789

Published: Feb. 4, 2024

The effects of excessive ultra-processed food (UPF) consumption on body composition measures or sociodemographic disparities are understudied in Korea. We aimed to investigate the association UPF intake with percent fat (PBF) and appendicular skeletal muscle mass (PASM) by status adults. This study used data from Korea National Health Nutrition Examination Survey 2008-2011 (n=11,123 aged ≥40 years). a NOVA system classify all foods reported 24-hour dietary recall, percentage energy (%kcal) UPFs was estimated. PBF PASM were measured dual-energy X-ray absorptiometry. Tertile (T) 3 indicated adiposity T1 low mass, respectively. Multinomial logistic regression models estimate odds ratios (OR) 95% confidence interval (CI) after adjusting covariates. positively associated PBF-defined (ORper 10% increase, 1.04; CI, 1.002 1.08) 1.05; 1.01 1.09). These associations stronger rural residents (PBF: ORper 1.14; 1.06 1.23; PASM: 1.15; 1.07 1.23) not college graduates 1.06; 1.02 1.11; 1.07; 1.03 1.12) than their counterparts. A higher lower among Korean adults 40 years older, particularly those areas education levels.

Language: Английский

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Association between kimchi consumption and obesity based on BMI and abdominal obesity in Korean adults: a cross-sectional analysis of the Health Examinees study

BMJ Open, Journal Year: 2024, Volume and Issue: 14(2), P. e076650 - e076650

Published: Jan. 30, 2024

Objective Previous animal studies have shown the anti-obesity effect of kimchi-derived probiotic lactic acid bacteria. However, only a few epidemiological investigated association between kimchi consumption and obesity. Therefore, we aim to assess this relationship in Korean adults. Design Cross-sectional study. Setting The Health Examinees study was conducted from 2004 2013. Participants This analysed 115 726 participants aged 40–69 years enrolled Korea. Primary secondary outcome measures Obesity defined as body mass index ≥25 kg/m 2 , abdominal obesity waist circumference ≥90 cm men ≥85 women. Kimchi assessed by validated food frequency questionnaire. Results In men, total 1–3 servings/day related lower prevalence (OR: 0.875 1–2 OR: 0.893 2–3 servings/day) compared with <1 serving/day. Also, highest baechu (cabbage kimchi) had 10% odds who consumed kkakdugi (radish ≥median were inversely associated 8% 11% women non-consumers, respectively. Conclusions relevance Consumption risk men. Baechu both since all results showed ‘J-shaped’ association, it is recommended limit excessive intake.

Language: Английский

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2023 Clinical Practice Guidelines for Diabetes

Journal of Korean Diabetes, Journal Year: 2023, Volume and Issue: 24(3), P. 120 - 126

Published: Sept. 30, 2023

The Committee on Clinical Practice Guidelines of the Korean Diabetes Association updated previous clinical practice guidelines for adults with diabetes and prediabetes published eighth edition in May 2023. We performed a comprehensive systematic review recent trials evidence suitable population that could be applicable to real-world practice. These were developed enable all healthcare providers including physicians, experts, certified educators nationwide best care individuals setting. recommendations screening, medical nutrition therapy, pharmacologic therapy type 2 diabetes, obesity, hypertension, lipid management revised updated. use real-time continuous glucose monitoring (CGM) devices was recommended 1 treated multiple insulin injections, additional CGM metrics added blood control target.

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease with Increased Alcohol Intake Increase the Risk of Developing Hepatocellular Carcinoma and Incident or Decompensated Cirrhosis: A Korean Nationwide Study

Liver Cancer, Journal Year: 2023, Volume and Issue: 13(4), P. 426 - 437

Published: Dec. 22, 2023

<b><i>Introduction:</i></b> This study aimed to investigate the liver-related outcomes of newly suggested metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD with increased alcohol intake (MetALD), as well alcohol-associated (ALD). <b><i>Methods:</i></b> From a National Health Insurance Service Screening Cohort, we included 369,094 participants who underwent health checkups between 2009 2010 in South Korea. Steatotic (SLD) was defined fatty index ≥60. The risk primary cancer (PLCa), hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), incident cirrhosis, decompensated cirrhosis compared no SLD. subdistribution hazard ratio (SHR) calculated using Fine-Gray model regarding competing risks. <b><i>Results:</i></b> A total 3,232 (0.9%) developed PLCa during median follow-up 3,227,176 person-years: 0.5% SLD, 1.1% MASLD, 1.3% MetALD, 1.9% ALD. Competing analysis revealed that (SHR: 1.65; 95% CI: 1.44−1.88), MetALD 1.87; 1.52−2.29), ALD 1.86; 1.39−2.49) were associated an PLCa. 1.96; 1.67−2.31), 2.23; 1.75−2.84), 2.34; 1.67−3.29) higher HCC. No significant difference observed iCCA. order <b><i>Conclusion:</i></b> have PLCa, HCC, but not These findings may serve robust ground for prognostic value MetALD.

Language: Английский

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