Bioactivities and Industrial Standardization Status of Ganoderma lucidum: A Comprehensive Review

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e36987 - e36987

Published: Aug. 29, 2024

(GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as dietary supplement, herbal remedy, wellness product steadily on the rise. Furthermore, standardized advancement GL industry has facilitated reliable sourcing raw materials quality control measures, enhancing its utilization endorsement in realms science pharmaceutical research. This article provides comprehensive overview recent advancements research pertaining to components GL, particularly polysaccharides (GLP) triterpenes (GLTs) well highlights latest findings regarding their beneficial effects human diseases, including anticancer, antidiabetes, liver protection other aspects (such regulating gut microbiota, antioxidant, antimicrobial, antiinflammatory immune regulation). we summarized potential applications food sectors, while also examining current status standardization throughout entire industrial chain both domestically internationally. These information offer an insight guidance for prospects development innovative within global health industry.

Language: Английский

Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 23, 2025

Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration most active components in species or genotypes, new formulation techniques development. In recent years, there has been a growing interest use nanomaterials because significant pharmacology applications as substance carriers. Applying nanoparticles may enhance medicinal effect mushroom substances. This study investigated properties methanolic extracts against HeLa line. Notably, extract obtained from pfeifferi highest activity was further used encapsulation within synthesized mesoporous silica MCM-41. Subsequently, loaded MCM-41 to free form compared. The results indicate successful encapsulation, similar comparing encapsulated (IC 50 16.6 μg/mL 20.5 μg/mL, respectively). addition, four unique compounds were identified applanoxidic acid A, G, ganoderone B G. pfeifferi. is an essential prerequisite steps like nanoparticle functionalization sustained on-command delivery these natural extracts.

Language: Английский

Effects of Ganoderma lucidum Supplementation on Obesity and Metabolic Alterations Induced by High‐Carbohydrate‐High‐Fat Diet in Rats

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Ganoderma lucidum (GL), commonly called Reishi mushroom, has been utilized in traditional medicine against multiple ailments including obesity and metabolic complications. The purpose of this study was to evaluate the ability powdered supplementation GL (2.5% w/w diet) its ameliorate associated alterations high‐carbohydrate‐high‐fat (HCHF) diet–fed obese female Wistar rats. Thus, after 56 days feeding mice with different treatments, we measured physiological parameters effect. Phytochemical analysis by HPLC identified bioactive polyphenols GL. Results demonstrated that significantly ( p < 0.05) prevented net rise body weight reduced organ weights abdominal fat deposition It improved glucose intolerance, decreasing blood level (6.2 nmol/L) compared HCHF diet–induced rats (8.67 nmol/L). also ameliorated plasma lipids total cholesterol (106.4 mg/dL), triglyceride, LDL‐C (55.26 VLDL‐C, restored elevated serum profiles alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP), antioxidant enzymes superoxide dismutase (SOD) (42.58 U/g tissue), catalase (CAT) activities, glutathione (GSH) (62.63 nmol/g tissue) Furthermore, hepatic infiltration preventing steatosis. Different catechin, rutin, cinnamic acid, vanillic quercetin, ferulic kaempferol were detected analysis, which might be responsible for activity. Bangladeshi cultivated possesses antiobesity effect is rich phenolics could prevent obesity‐associated disorders.

Language: Английский