A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 165 - 165

Published: Jan. 11, 2025

Fibromyalgia represents a chronic pain disorder characterized by musculoskeletal pain, fatigue, and cognitive impairments. The exact mechanisms underlying fibromyalgia remain undefined; as result, diagnosis treatment present considerable challenges. On the other hand, endogenous opioid system is believed to regulate intensity emotional responses; hence, it might be expected play key role in enhanced sensitivity experienced patients. One explanation for emergence of disrupted modulation individuals with significant reduction receptor activity or an imbalance levels peptides. Further research essential clarify complex details this abnormality. This complexity arises from notion that improved understanding could contribute development innovative therapeutic strategies aimed at targeting context fibromyalgia. Although progress being made, complete these complexities remains challenge. paradigm has potential revolutionize management fibromyalgia, although its implementation may experience effectiveness approach depends on multiple factors, but implications profound. Despite challenges involved transformation, improving patient care considerable, condition long been inadequately treated.

Language: Английский

---

The effectiveness of stretching exercises in patients with fibromyalgia: A systematic review

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(10), P. 3039 - 3053

Published: Aug. 6, 2024

Language: Английский

---

The potential impact of exercise on affect and neuroinflammation in older adults living with fibromyalgia: a scoping review

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 6, 2025

Fibromyalgia (FM) is a widespread chronic pain condition with prevalence increasing in older adults. Older adults living FM experience longer symptom durations that can negatively impact their quality of life. Affect and neuroinflammation are potential factors exacerbate symptoms. Exercise recommended intervention to manage symptoms; however, adherence limitations persist. Drawing on the Biopsychosocial Framework Chronic Pain, this scoping review explores how exercise impacts related affect, these contribute FM. We conducted search articles published before 2024. The extracted study characteristics include publication type, design, affect outcomes, adherence, sample demographic information. have provided an overview relationship between studies including highlight A conceptual framework illustrating reciprocal exercise, affective changes, neuroinflammation, adherence. Our results suggest may improve while limited evidence suggests aerobic resistance neuroinflammation. Finally, implications for importance future directions context biological impacted provided.

Language: Английский

---

Milnacipran and Vanillin Alleviate Fibromyalgia-Associated Depression in Reserpine-Induced Rat Model: Role of Wnt/β-Catenin Signaling

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Fibromyalgia (FM) patients are highly susceptible to depression. Wnt/β-catenin signaling has shown a crucial role against depression in several studies. The FDA-approved FM drug, milnacipran (Miln), antinociceptive potential FM. Yet, no study investigated its antidepressant Vanillin (Van), well-known phytochemical often employed as flavoring agent, been previously reported for and effects animal models, but not tested so far This explored the effect of Van Miln through investigating signaling. was induced female Wistar rats by injecting reserpine (1 mg/kg/day s.c) 3 days. Thereafter, animals received either (30 p.o) or (100 subsequent 14 Results showed that both drugs demonstrated forced swimming test besides analgesic, antiallodynic influences observed Randall-Selitto, hot plate, cold allodynia, Von-Frey, tail immersion tests. Biochemically, significantly enhanced serotonergic transmission hippocampus upregulated protein expression Wnt/GSK-3β/β-catenin axis, including downstream proteins, T cell factor, dicer. is followed upregulation resilience micro ribonucleic acids (miRNAs) 124 135. Histopathological examinations corroborated biochemical molecular findings. Interestingly, these were overturned via administration β-catenin inhibitor, XAV939 (0.1 mg/kg, i.p., daily). In conclusion, this outlined aptitude activating reserpine-induced

Language: Английский

---

Fibromyalgia and Inflammation: Unrevealing the Connection

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 271 - 271

Published: Feb. 13, 2025

Fibromyalgia represents a chronic pain pathology characterized by severe musculoskeletal pain, fatigue, disturbances in sleep, and cognitive issues. Despite its presence, the underlying mechanisms of fibromyalgia remain inadequately understood; however, recent investigations have suggested that inflammation could play fundamental role pathophysiology this condition. Several studies highlight elevated concentrations pro-inflammatory cytokines, dysregulation immune responses, neuroinflammation patients. Furthermore, low-grade has been proposed as potential catalyst for sensitization pathways, which exacerbates symptoms fibromyalgia. Understanding disease might open new avenues therapeutic interventions while providing more profound insight into complex nature debilitating disorder. Although progress made, further research is needed to uncover complexities involved. This review investigates intricate relationship between fibromyalgia, analyzing evidence supports involvement both peripheral central inflammatory processes onset persistence

Language: Английский

---

Efficacy of a home-based stretching programme on fibromyalgia symptoms: study protocol for a randomised controlled trial

Trials, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 27, 2025

This protocol was developed to describe the design of a randomised controlled trial that will examine clinical efficacy 6-week, novel, home-based stretching programme compared with usual care on effect symptoms experienced by patients fibromyalgia. The hypothesis is total score Fibromyalgia Impact Questionnaire (FIQ-R) and other fibromyalgia improve 6 weeks following intervention care. Fifty-eight adults under 65 years age diagnosed be recruited for this study. Participants into an group control (waitlist). Randomisation stratified sex. perform daily exercises min—a day. maintain A mHealth app support adherence. primary outcome Revised (FIQ-R). secondary outcomes include regional widespread pain sensitivity, range motion, quality life (SF-36), mental physical functioning Evaluations performed at baseline, stretches (primary endpoint) months after termination period (secondary endpoint). By investigating programme, we hope provide applicable generalisable knowledge about can potentially help ease burden NTC, NCT06487741. Registered 24 June 2024.

Language: Английский

---

Exploring Pain Reduction through Physical Activity: A Case Study of Seven Fibromyalgia Patients

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 765 - 765

Published: July 29, 2024

Fibromyalgia is a chronic disease that affects considerable fraction of the global population, primarily women. Physical activity often recommended as tool to manage symptoms. In this study, we tried replicate positive result pain reduction through physical activity. After collecting and data from seven women with fibromyalgia, one patient experienced in intensity. According patient, improvement was related Our study conducted investigate replicability personalized recommendations. Out other six patients, three pain. The remaining patients did not experience any relief. results show two these were able follow These indicate may have effect on patients. To estimate how effective can be for group, an intervention longer follow-ups larger sample sizes needs performed future.

Language: Английский

---

Fibromyalgia : A review

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2024, Volume and Issue: 22(3)

Published: Jan. 1, 2024

This paper reviews guidelines of fibromyalgia. Fibromyalgia is a common medical condition which still misdiagnosed with other rheumatological disorders. It can be complex and brings many challenges. Presentation vary from patient to patient. estimated that around up 5% population may have fibromyalgia more cases in women. Although there no cure for this condition, understanding contribute well-rounded effective treatment therapy options via multidisciplinary approach help relieving the symptoms. Keywords : fibromyalgia, challenges, approach, therapy,

Language: Английский

---

Effect of Prophylactic Tropisetron on Post-Operative Nausea and Vomiting in Patients Undergoing General Anesthesia: Systematic Review and Meta-Analysis with Trial Sequential Analysis

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(8), P. 797 - 797

Published: July 27, 2024

This systematic review and meta-analysis of randomized controlled trials (RCTs) with trial sequential analysis (TSA) aimed to comprehensively evaluate compare the efficacy prophylactic administration tropisetron in prevention incidence post-operative nausea vomiting (PONV) patients undergoing surgery under general anesthesia. study was registered PROSPERO (CRD42024372692). RCTs comparing perioperative that a placebo, other anti-emetic agents, or combination injections were retrieved from databases Ovid-MEDLINE, Ovid-EMBASE, Cochrane Central Register Controlled Trials, Google Scholar. The frequency rescue use (RA) PON, POV, PONV (relative risk [RR]: 0.718; 95% confidence interval [CI] 0.652–0.790; I2 = 0.0, RR: 0.587; CI 0.455–0.757; 63.32, 0.655; 0.532–0.806; 49.09, 0.622; 0.552–0.700; 0.00, respectively) group lower than those control group; however, complete response (CR) higher (RR: 1.517;95% 1.222–1.885; 44.14). TSA showed cumulative Z-curve exceeded both conventional test monitoring boundaries for RA, between group. Thus, exhibited superior PONV. Furthermore, RA CR observed its use.

Language: Английский

---

Fibromyalgia: recent concepts and treatments

International Physical Medicine & Rehabilitation Journal, Journal Year: 2024, Volume and Issue: 9(1), P. 13 - 15

Published: Jan. 30, 2024

Fibromyalgia is a chronic pain syndrome characterized by widespread often accompanied symptoms that compromise quality of life, such as fatigue, sleep disorders, cognitive dysfunction, mood disorders. The pathology affects millions people around the world and still overlooked misunderstood. Although its pathophysiology not fully understood, it believed Central Sensitization plays preponderant role in genesis disease. In addition, several studies demonstrate genetic polymorphisms genes related to syndromes, thresholds, psychological others pathologies frequently associated with Fibromyalgia. Different diagnostics criteria have been proposed define disease, however, 2010 ACR revised 2016 considered most suitable. Functional imaging exams were great importance determining pathophysiological mechanisms so, therapeutic options. A variety randomized controlled systematic reviews demonstrated efficacy pharmacological non-pharmacological approach for This article aims provide current view concepts, from possible therapeutics.

Language: Английский

---