COVID-19 Pandemic Encourages to Deepen the Study of the Thyroid Gland: Correlation Portraits as a Means of Research in Different Directions of Follicular Thyrocytes Activities

SSP Modern Pharmacy and Medicine, Journal Year: 2022, Volume and Issue: 2(1), P. 1 - 21

Published: Feb. 1, 2022

In COVID-19, the thyroid gland can play a significant role both in clinical course of disease and processes postcovid recovery. Based on importance for vital functions body, information etiology most common types pathology is considered. It established that disclosure deep essence occurring normal possible basis innovative use correlation analysis with designing portraits to study main activities follicular thyrocytes.

Language: Английский

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Functional hypogonadism in men: key causes and neuroendocrine mechanisms of its development

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 6, P. 112 - 123

Published: May 19, 2024

Modern concepts of hypogonadism in men are undergoing significant transformation. The concept functional hypogonadism, which is gaining increasing support among expert communities today, based on the reversibility symptomatic hypotestosteronemia after eliminating causal factor or disease with an intact hypothalamic-pituitary-gonadal system. This makes diagnosis exclusion organic can be congenital (genetic) acquired (destructive structural) irreversible disorder occurring at any level axis. Functional becoming more common, attributed to its association non-infectious pandemics such as obesity, type 2 diabetes, and other comorbid pathologies. Additionally, age-related meets criteria accumulating age-associated comorbidities have been shown play a role testosterone decline aging men. Moreover, excessive physical activity, drastic calorie restriction, high psycho-emotional stress, injuries, surgeries, use certain medications also causes hypogonadism. Despite wide range heterogeneity diseases conditions underlying mechanisms driving development quite similar since most cases, this androgen deficiency secondary hypogonadotropic (central). However, some primary mixed. Therefore, understanding pathogenesis crucial it involves variety biological pathways depending etiological disease, detailed through literature review. article pays special attention evolutionary significance phenomenon adapted classification causes, describes achievements Russian researchers who studied impact acute extreme influences system

Language: Английский

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CONDITION OF HYPOTHALAMICPITUITARY- GONADAL SYSTEM IN MILITARY PERSONNEL. LITERATURE REVIEW

Медицинский вестник МВД, Journal Year: 2024, Volume and Issue: 2024(4), P. 41 - 48

Published: Sept. 10, 2024

This review paper provides an analysis of publications on change and misfunctioning the hypothalamic-pituitary-gonadal system through prism factors accompanying military service. The detectable decrease in testosterone levels as a result effects those factors, well use replacement therapy personnel, are considered detail this and, certainly, need further study.

Language: Английский

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International Legal Problems of the Climate Change Effects on the Environment (on the Examples of Biological Diversity Degradation and Chemicals and Waste Management)

Kutafin Law Review, Journal Year: 2024, Volume and Issue: 11(4), P. 633 - 633

Published: Dec. 30, 2024

Climate change is an existential threat to humanity: scientific data shows that every year the average temperature on Earth getting higher and higher. Within framework of international law, a set measures being taken mitigate adapt effects climate change. Given comprehensive nature impacts environment, detailed legal are required in various areas cooperation. In this study authors examined complexities regulation two impacts: management chemicals waste, as well preservation biological diversity genetic resources. The conducted identified achievements problems these also showed for purposes synergy treaties studied decisions made at periodic conferences parties treaties.

Language: Английский

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Climatic and chemical health risk factors for people living in arctic and subarctic regions: population and sub-population levels

Health Risk Analysis, Journal Year: 2022, Volume and Issue: 3, P. 39 - 52

Published: Sept. 1, 2022

The article dwells on climatic and chemical risk factors that influence health of people living in the RF arctic sub-arctic regions population sub-population levels. We used a model describing cause-effect relations between environmental life expectancy at birth based an artificial neural network to predict future medical demographic situation territories with climate RF. Children’s was examined profoundly due participating representative sampling. comparatively analyzed clinical, biochemical general clinical indicators test reference groups using standard statistical procedures software packages. established average monthly temperatures July grew by 3.4 % over 2010–2019 RF; precipitations January 13.0–15.1 %. presents differentiated estimates emerging (LEB) exerted weather conditions climate. Losses LEB vary from 164 days Yakutia 349 Chukotka. Aggregated zones produced variable effects LEB, starting negative ones resulted its decline Magadan region, Nenets Autonomous Area, Chukotka, Yamal-Nenets Area (-254; -211; -109 -8 accordingly) positive led growth up 111 Yakutia. Children who are simultaneously exposed adverse zone substantial pollution ambient air have more frequent apparent changes their comparison children group. Thus, respiratory diseases nervous system were 5.6 times group; levels leukocytes, ESR, TSH, Apo-B Apo-B/ApoA1 blood 1.3–1.7 higher, р = 0.0001. Levels Apo A1, hydrocortisone, serotonin 1.2–2.5 lower, 0.0001–0.040, etc. A share contribution made associated amounted 25–31 %; factors, 10–15

Language: Английский

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THE HEMODYNAMICS OF PERIODONTAL TISSUES IN YOUNG PATIENTS IN A STATE OF EMOTIONAL STRESS

The actual problems in dentistry, Journal Year: 2018, Volume and Issue: 14(1), P. 37 - 42

Published: Feb. 25, 2018

Language: Английский

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MORPHOLOGICAL AND MORPHOMETRIC REARRANGEMENTS OF THE RAT ADENOHYPOPHYSIAL-THYROID SYSTEM UNDER THE EXPERIMENTAL EXTRACELLULAR DEHYDRATION

World of Medicine and Biology, Journal Year: 2019, Volume and Issue: 15(68), P. 174 - 174

Published: Jan. 1, 2019

Language: Английский

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Assessment of Cardiac Vegetative Control during Acute Graduated Exogenous Normobaric Hypoxia in Rats

Bulletin of Experimental Biology and Medicine, Journal Year: 2018, Volume and Issue: 164(5), P. 591 - 595

Published: March 1, 2018

Language: Английский

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ОСНОВНЫЕ ГЕМАТОЛОГИЧЕСКИЕ И МЕТАБОЛИЧЕСКИЕ ПОКАЗАТЕЛИ КРОВИ У ЛЕТНОГО СОСТАВА НА РАЗНЫХ СРОКАХ СЛУЖБЫ В УСЛОВИЯХ АРКТИКИ

Биосфера, Journal Year: 2020, Volume and Issue: unknown, P. 211 - 226

Published: Feb. 14, 2020

Проведена оценка ряда показателей периферической крови военнослужащих летного состава в условиях Крайнего Севера на разных сроках службы: сразу по прибытии Крайний Север и третьем, шестом двенадцатом месяцах службы. Определяли метаболические показатели (холестерин общий липопротеинах высокой, низкой очень плотности, триглицериды, глюкоза, билирубин коэффициент атерогенности), лейкоцитарную формулу содержание эритроцитов крови. Эти группах с разными сроками службы полярных сравнивались между летчиками клинически здоровыми (контроль) имеющим диагнозы различных заболеваний пограничных состояний, не исключающих деятельность специальности: остеохондроз позвоночника, гастродуодинит, миокардиодистрофии, нейроваскулярная дистония, пограничная артериальная гипертензия. При сравнении контролем последних трех выявлены статистически значимые возрастания содержания общего холестерина (на 11,7–17%); липопротеидов высокой плотности (5,1–7%); (10,4–14,1%); (17,2–27,6%); коэффициента атерогенности (9,8–11,8%) триглицеридов (15,6–18%); глюкозы (6,1–14,6%) билирубина (22,6–25%); палочкоядерных нейтрофилов (18,2–27,3%); сегментоядерных (5,7–14,4%); эозинофилов (15,4– 23,1%); моноцитов (13,2–21,1%); лимфоцитов (9,1–11,4%); эритроцитов. Наиболее выраженными изменения были случаях гипертензии. Результаты обсуждены связи особенностями адаптации к стрессу, вызываемому условиями Севера.

Language: Русский

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IL-2 and regulation of stress hormones and BDNF neurotropic factor levels after experimental traumatic brain injury (TBI)

Medical Immunology (Russia), Journal Year: 2020, Volume and Issue: 22(4), P. 647 - 656

Published: Aug. 7, 2020

Experimental traumatic brain injury (TBI) causes a stable stress response and changes the expression of various cytokine genes neurotrophic factors. The goal this study was to reveal in levels corticosterone testosterone hormones BDNF blood serum, as well gene hypothalamus order determine opportunity correcting TBI damage with rIL-2. We used rat model "dropping load": mild caused by falling 115 g load from height 80 cm, or 120 cm produce moderate-degree trauma. After (immediately, 72 hours later), rats were injected daily recombinant human interleukin-2 (Roncoleukin) at dose 30 μg/kg, total 3 injections. Control animals (also TBI) received 0.15 M NaCl Blood serum concentrations corticosterone, testosterone, measured ELISA tests. using RT-PCR. Results: experiments showed relationship between hormone severity head injury. In TBI, reached peak 2 after injury, while moderate concentration lower, being delayed time (after 24 hours). Corticosterone changed reciprocally both groups injured animals. With injection rIL-2 groups, significantly increased. On day 7 level decreased, but it raised experimental group that 7, increase more pronounced, when administered revealed positive association glucocorticoid like possible coordination these parameters provides reason assume favorable impact on CNS recovery is, part, mediated mutual modulating interaction hormones.

Language: Английский

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