Heat Stress-Induced DNA Damage Creative Commons

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Kantidze O.L.,

Velichko A.K.

ACTA NATURAE, Journal Year: 2016, Volume and Issue: 8(2), P. 75 - 78, https://doi.org/10.32607/20758251-2016-8-2-75-78

Published: Jan. 1, 2016

Latest article update: Sept. 27, 2022

Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.

Mechanisms of DNA damage, repair, and mutagenesis DOI
Nimrat Chatterjee,

Graham C. Walker

Environmental and Molecular Mutagenesis, Journal Year: 2017, Volume and Issue: 58(5), P. 235 - 263

Published: May 9, 2017

Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust repair damage-bypass mechanisms faithfully protect the by either removing or tolerating damage ensure an overall survival. Deviations in this fine-tuning known destabilize cellular metabolic homeostasis, as exemplified diverse cancers where disruption deregulation pathways results genome instability. Because routinely used biological, physical chemical human health, testing their genotoxicity regulating use have become important. In introductory review, we will delineate counteracting repair/tolerance provide insights into molecular basis cells lays foundation for subsequent articles issue. Environ. Mol. Mutagen. 58:235-263, 2017. © 2017 Wiley Periodicals, Inc.

Language: Английский

Citations

1588
A positive correlation between GC content and growth temperature in prokaryotes DOI Creative Commons
En-Ze Hu,

Xin-Ran Lan,

Zhi-Ling Liu

et al.

BMC Genomics, Journal Year: 2022, Volume and Issue: 23(1)

Published: Feb. 9, 2022

GC pairs are generally more stable than AT pairs; GC-rich genomes were proposed to be adapted high temperatures AT-rich genomes. Previous studies consistently showed positive correlations between growth temperature and the contents of structural RNA genes. However, for whole genome sequences silent sites codons in protein-coding genes, relationship content is a long-lasting debate.

Language: Английский

Citations

75
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases DOI Creative Commons
Sina Shadfar, Sonam Parakh, Md Shafi Jamali

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: April 14, 2023

Abstract Redox homeostasis refers to the balance between production of reactive oxygen species (ROS) as well nitrogen (RNS), and their elimination by antioxidants. It is linked all important cellular activities oxidative stress a result imbalance pro-oxidants antioxidant species. Oxidative perturbs many activities, including processes that maintain integrity DNA. Nucleic acids are highly therefore particularly susceptible damage. The DNA damage response detects repairs these lesions. Efficient repair essential for maintaining viability, but they decline considerably during aging. deficiencies in increasingly described age-related neurodegenerative diseases, such Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis Huntington’s disease. Furthermore, has long been associated with conditions. Moreover, both redox dysregulation increase significantly aging, which biggest risk factor diseases. However, links dysfunction damage, joint contributions pathophysiology conditions, only just emerging. This review will discuss associations address increasing evidence an major source disorders. Understanding connections may facilitate better understanding disease mechanisms, ultimately lead design therapeutic strategies based on preventing

Language: Английский

Citations

64
Stress Management in Plants: Examining Provisional and Unique Dose-Dependent Responses DOI Open Access
Mariyana Georgieva, Valya Vassileva

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5105 - 5105

Published: March 7, 2023

The purpose of this review is to critically evaluate the effects different stress factors on higher plants, with particular attention given typical and unique dose-dependent responses that are essential for plant growth development. Specifically, highlights impact genome instability, including DNA damage molecular, physiological, biochemical mechanisms generate these effects. We provide an overview current understanding predictable trends in survival when exposed low or high doses stress. Understanding both negative positive impacts responses, can insights into how plants react levels stress, yielding more accurate predictions their behavior natural environment. Applying acquired knowledge lead improved crop productivity potential development resilient varieties, ensuring a sustainable food source rapidly growing global population.

Language: Английский

Citations

33
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability DOI
Srijit Seal, Jordi Carreras‐Puigvert, Shantanu Singh

et al.

Molecular Biology of the Cell, Journal Year: 2024, Volume and Issue: 35(3)

Published: Jan. 3, 2024

Cell Painting assays generate morphological profiles that are versatile descriptors of biological systems and have been used to predict in vitro vivo drug effects. However, features extracted from classical software such as CellProfiler based on statistical calculations often not readily biologically interpretable. In this study, we propose a new feature space, which call BioMorph, maps these with readouts comprehensive Health assays. We validated the resulting BioMorph space effectively connected compounds only associated their bioactivity but deeper insights into phenotypic characteristics cellular processes given bioactivity. The revealed mechanism action for individual compounds, including dual-acting emetine, an inhibitor both protein synthesis DNA replication. Overall, offers relevant way interpret cell derived using hypotheses experimental validation.

Language: Английский

Citations

12
The molecular mechanism of aging and the role in neurodegenerative diseases DOI Creative Commons
Juanli Zhao,

Zhenjie Han,

Li Ding

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24751 - e24751

Published: Jan. 1, 2024

Aging is a complex and inevitable biological process affected by combination of external environmental genetic factors. Humans are currently living longer than ever before, accompanied with aging-related alterations such as diminished autophagy, decreased immunological function, mitochondrial malfunction, stem cell failure, accumulation somatic DNA mutations, loss telomere, altered nutrient metabolism. leads to decline in body functions age-related diseases, for example, Alzheimer's disease, which adversely affects human health longevity. The quality life the elderly greatly increase their expectancy rather healthy expectancy. With rise age global population, aging related diseases have become focus attention worldwide. In this review, we discuss several major mechanisms aging, including damage repair, free radical oxidation, telomeres telomerase, damage, inflammation, role neurodegenerative provide reference prevention its diseases.

Language: Английский

Citations

9
Manganese-Doped Magnetic Nanoclusters for Hyperthermia and Photothermal Glioblastoma Therapy DOI
Ruby Gupta, Deepika Sharma

ACS Applied Nano Materials, Journal Year: 2020, Volume and Issue: 3(2), P. 2026 - 2037

Published: Jan. 22, 2020

The development of nanostructures with complementary functionalities has emerged as a prerequisite for more efficient preclinical nanoparticle-mediated thermo-therapeutic research. Here, we report the bimodal application manganese doped-iron oxide nanoclusters photothermal and magnetic hyperthermia-mediated glioblastoma therapy. Besides combinatorial effect, have also explored comparative effects single-mode therapies when seldom used in terms cell viability, oxidative stress production, reduction mitochondrial membrane potential, cytoskeletal damage, morphological alterations. In all aspects, exposure to hyperthermia was shown higher therapeutic effect than therapy alone. However, it is ultimately consequence that results significant death rat glioma C6 cells. Excitation cells laser observed create cellular environment which enhanced efficiency hyperthermia, resulting remarkable anticancer mediated by ROS-dependent apoptosis via pathway.

Language: Английский

Citations

63
Prospects for gene introgression or gene editing as a strategy for reduction of the impact of heat stress on production and reproduction in cattle DOI
Peter J. Hansen

Theriogenology, Journal Year: 2020, Volume and Issue: 154, P. 190 - 202

Published: May 23, 2020

Language: Английский

Citations

61
Microbiome and ecology of a hot spring-microbialite system on the Trans-Himalayan Plateau DOI Creative Commons
Chayan Roy,

Moidu Jameela Rameez,

Prabir Kumar Haldar

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: April 3, 2020

Little is known about life in the boron-rich hot springs of Trans-Himalayas. Here, we explore geomicrobiology a 4438-m-high spring which emanates ~70 °C-water from boratic microbialite called Shivlinga. Due to low atmospheric pressure, vent-water close boiling point so can entropically destabilize biomacromolecular systems. Starting vent, Shivlinga's was revealed along thermal gradients an outflow-channel and progressively-drying mineral matrix that has no running water; ecosystem constraints were then considered relation those comparable environments. The spring-water chemistry sinter mineralogy dominated by borates, sodium, thiosulfate, sulfate, sulfite, sulfide, bicarbonate, other macromolecule-stabilizing (kosmotropic) substances. Microbial diversity high both hydrothermal gradients. Bacteria, Eukarya Archaea constituted >98%, ~1% <1% microbiome, respectively. Temperature constrained biodiversity at ~50 °C ~60 °C, but not below 46 °C. Along each gradient, vent-to-apron trajectory, communities Aquificae/Deinococcus-Thermus, Chlorobi/Chloroflexi/Cyanobacteria, finally Bacteroidetes/Proteobacteria/Firmicutes. Interestingly, sites >45 inhabited phylogenetic relatives taxa for laboratory growth highlights possibility system's kosmotrope-dominated mitigates against biomacromolecule-disordering effects its water.

Language: Английский

Citations

51
The Effects of Localized Heat on the Hallmarks of Cancer DOI
Gary Hannon, Felista L. Tansi, Ingrid Hilger

et al.

Advanced Therapeutics, Journal Year: 2021, Volume and Issue: 4(7)

Published: May 13, 2021

Abstract Heat has been used to treat tumors for thousands of years. There are reports the Egyptians and Greek philosophers using such treatments as far back 3000 BC 500 respectively various solid tumors. Albeit, in these cases, treatment was not very controlled consisted hot sticks or blades placed against tissue order thermally ablate tumor. It until recent times that application heat through mediums enabled a more controlled, localized, consistent method treating While therapeutic potential this become apparent, mechanisms related its efficacy only recently beginning surface. This review discusses evidence associated with effects localized on hallmarks cancer. Key literature describing modulations vasculature, cell viability, DNA damage repair, metabolism, immune system, tumor metastasis response will be reviewed along considerations optimal implementation clinic enhance conventional treatments.

Language: Английский

Citations

49