Chronic endometritis: A protracted discussion

Ural Medical Journal, Journal Year: 2023, Volume and Issue: 22(2), P. 142 - 152

Published: April 30, 2023

Introduction Chronic endometritis is one of the most important factors leading to reduced fertility in women. The protracted discussion about presence this nosology clinical practice for more than 100 years does not allow establish true frequency chronic women reproductive age. At present stage, due unfavorable demographic situation both Russian Federation and many countries, study endometritis, as main determinants lesions morphological functional state endometrium, relevant. purpose determine current problem verification with infertility, losses repeated failure assisted technologies (ART). Materials methods sources information were publications from databases PubMed, Google Scholar, elibrary.ru medical journals field obstetrics gynecology, well pathological anatomy period 2013 2022. Results An analysis literature showed that cause miscarriage ineffective ART protocols leads decrease regenerative potential endometrial reserve. Despite evidence negative impact on function, at regarding diagnostic approaches continues. use histological method research, available diagnosing always verify which dictates need using high technological confirm clarify severity process. Conclusion A unified algorithm patients miscarriage, cycles a qualified approach diagnosis standardization competent interpretation immunohistochemical data make it possible select pathogenetically substantiated therapy aimed rehabilitation function.

Language: Английский

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Endometrial implantation failure in cycles of in vitro fertilization in patients with chronic endometritis

CLINICAL AND EXPERIMENTAL MORPHOLOGY, Journal Year: 2023, Volume and Issue: 12(1), P. 24 - 33

Published: Jan. 1, 2023

Introduction. Chronic endometritis is one of the most frequent gynecological diseases which negatively impacts main pathogenetic links in morphogenesis secretory and gestational endometrial transformation. These determine implantation failure. The study aimed to verify expression estrogen receptors (ER) progesterone (PR), progesterone-induced blocking factor (PIBF) stromal cell-derived factor-1 (SDF-1) endometrium patients having chronic with ineffective IVF cycles or undeveloped pregnancies occurred after assisted reproductive technologies their histories. Materials methods. We formed 3 groups: group I included samples (n=50); II contained received from a history pregnancy III (the control group) tissue healthy (n=25). carried out routine histological evaluation followed by an immunohistochemical assay ER, PR, PIBF, SDF-1 glands stroma middle secretion phase. esults. stage phase menstrual cycle groups was detected only 46% 42% cases, respectively. showed decrease ER PR more than 92% cases. Statistically significant PIBF within window loss. Conclusion. Violation viability imbalance chemokines, cytokines, cellular factors, structural functional characteristics found revealed miscarriage ART. Keywords: endometrium,IVF, missed abortion IVF, receptor, factor,

Language: Английский

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Modern concepts about the problem of endometrial infertility against the backdrop of the "thin endometrium" (literature review)

Consilium Medicum, Journal Year: 2024, Volume and Issue: 26(7), P. 403 - 410

Published: Oct. 15, 2024

Endometrial infertility is the cause of inadequate implantation and serves as an obstacle to onset progression spontaneous pregnancy implementation assisted reproductive technology (ART) programs. One most common mechanisms for development endometrial thinning. Despite abundance publications, today there are no generally accepted diagnostic criteria treatment rehabilitation approaches this pathology, which encourages continued scientific research in direction. Aim was highlight problem decreased fertility caused by “thin endometrium”. To create review, bibliographic method applied domestic foreign literary sources from Pubmed, MedLine, RSCI, e-library Cyberleninka search engine databases were used. The depth 10 years. following phrases used: “uterine factor infertility”, “endometrial Seventy five that included review studied analyzed. Data presented literature indicate causes associated with incompetence uterine cavity mucosa, may manifest itself a phenomenon ”thin endometrium”, have not yet been fully studied. Determining functional status endometrium very important predicting natural cycle or ART programs, since even presence good quality embryo, deficiency can prevent adequate implantation. Thus, before planning subsequent pregnancy, it necessary diagnose and, if possible, neutralize correct infertility. main markers readiness at moment thickness endometrium.

Language: Английский

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Pregravid preparation for patients with a history of infertility and inefficacy of in vitro fertilization

Russian Bulletin of Obstetrician-Gynecologist, Journal Year: 2019, Volume and Issue: 19(5), P. 43 - 43

Published: Jan. 1, 2019

Language: Английский

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Clinical-immunohistochemical characteristics of atypical endometrial hyperplasia in women of reproductive age.

Medicni perspektivi, Journal Year: 2020, Volume and Issue: 25(1), P. 134 - 141

Published: April 9, 2020

The article presents the analysis of clinical-morphological and immunohistochemical features endometrial hyperplasia. 60 patients reproductive age with non-atypical hyperplasia (EH) were examined. following morphological distribution its different types was established: glandular – 56.6%, glandular-cystic 40.0%, stromal cystic-atrophic forms 1.7%, respectively. When carrying out studies, expression CD-138, a modern reliable marker presence an inflammatory process in tissue determined. In group EH, signs endometrium verified 7 (20.59%) patients. change EH 11 (45,83%) patients, as well only patient (100,0%). almost one-third 19 (31.7%) structural-morphological chronic endometritis revealed, which manifested by lymphoplasmacytic infiltration, indicating process. These data indicate possible pathogenetic role inflammation one trigger factors for hyperplastic transformation structures, allows to confirm infectious occurrence these processes third ЕН. Thus, conducted studies that development EН is based on both factor hormonal metabolic disorders, dictates personalized approaches therapeutic tactics.

Language: Английский

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Immunomorphological signs of chronic endometritis in patients after failed attempts of auxiliary reproductive technologies

Reproductive health of woman, Journal Year: 2022, Volume and Issue: 3, P. 27 - 33

Published: May 31, 2022

The objective: to analyze the morphological and immunohistochemical features of endometrium in patients with chronic endometritis after unsuccessful attempts assisted reproductive technologies (ART). Materials methods. A prospective study was conducted women a history on basis Medical Center LLC “ISIDA-IVF” for period from 2019 2021. I group included 55 age repeated ART, control (CG) – 40 without fertility disorders who are preparing replacement motherhood programs or oocyte donors. results endometrial biopsy performed 5–7th 19th–21st days menstrual cycle using pipelle aspiration curette were studied assessment immunomorphological characteristics endometritis. immunoperoxidase method primary specific monoclonal antibodies used estrogen progesterone receptors. Differences at p<0.05 considered statistically significant. Results. Pathomorphological revealed characteristic signs inflammation presence large number plasma cells stroma, lymphoid infiltrates near blood vessels gland orifices, unevenly expressed stroma fibrosis, sclerotic changes walls spiral arteries. All examined persons had two more (CE). An increase macrophages monocytes glands found by CE 31.3±2.9 % versus 2.3±0.1 CG (р<0.05). proliferative activity epithelium 5-7th day compared similar indicators secretion phase determined. proliferation glandular stromal cells, detected cycle, intensification programmed cell death process covering endometrium. This characterized structural nuclei marginal state chromatin, appearance karyorrhexis karyopyknosis. In capillary-type found, intensity their development strong correlation degree severity inflammatory (r=0.74; p<0.05). During receptors mainly decrease level expression both healthy - H-score 145.5±7.7 55.5±10.4 Conclusions. Immunomorphological demonstrates that tissues have clear criteria, which most pronounced sclerosis vessel walls, These persist secretory significant manifestations form

Language: Английский

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The role of abnormal vaginal microbiocenosis in increasing the risk of adverse reproductive outcome

Vrach, Journal Year: 2023, Volume and Issue: unknown, P. 53 - 56

Published: Jan. 30, 2023

Objective. To study vaginal microbiocenosis in pregnant women with poor perinatal outcome to determine the relationship between different types of infections and stillbirths. Subjects methods. A retrospective was conducted 154 divided into groups: a group 114 patients antenatal fetal death at 22 weeks’ gestation; control 40 physiological pregnancy same time. Results. The both groups were found have statistically significant abnormal flora: coagulase-negative Staphylococcus (41.2%), Enterococcus faecalis (29.4%), Escherichia coli (44.1%), aureus (11.1%), Klebsiella pneumoniae (12.9%), Candida albicans (28.8%). At time, these abnormalities significantly more commonly occurred group. Conclusion. Of great importance is determination opportunistic pathogens prevention adverse outcomes.

Language: Английский

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CLINICAL AND EXPERIMENTAL MORPHOLOGY, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

Endometrial implantation failure in cycles

Language: Английский

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Chronic endometritis and endometrial microsatellite instability: is there a connection?

Ural Medical Journal, Journal Year: 2023, Volume and Issue: 22(2), P. 16 - 23

Published: April 29, 2023

Introduction One of the criteria impaired DNA repair is microsatellite instability (MSI) resulting from functional insufficiency mismatched nucleotide (MMR) system, a complex proteins (MLH-1, PMS- 2, MSH-2, MSH-6). No data on study MSI in chronic endometritis (CE) were found available literature. The aim was to determine structural features endometrium female patients with inflammation uterine mucosa. Materials and methods Group I consisted 30 women morphologically confirmed high-grade CE; II low-grade III who sought pregnancy planning had histologically unchanged endometrium. degree CE groups variable. We analyzed expression levels MLH-1-, MSH- 2-, MSH-6-, PMS-2-proteins by estimating staining area nuclei cytoplasm affected cells over entire slice area. Nonparametric statistical Mann-Whitney test used. value probability error set at 0.05. Results There statistically significant decrease level MMR protein endometrial samples compared same indices women. results when analyzing depending severity CE. Discussion markers studied PMS-2, MSH-6) specimens low-activity mucosa biopsy highly active mid-stage secretion phase specimens. described morphological are consistent findings other authors. literature provides indications pre-tumor tumor processes Conclusion Endometrial low activity various degrees show significantly lower MLH-1, MSH-6 normal samples, which may indicate pathogenetic heterogeneity development

Language: Английский

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5. Successful realization of reproductive function in woman with uterus didelphys

Women s Health and Reproduction, Journal Year: 2023, Volume and Issue: 60(5)

Published: Jan. 1, 2023

Aim. Demonstration of a clinical case twice successfully completed surgical delivery in patient with uterus didelphys. Key points. Uterus didelphys is the result an embryological violation Muller ducts fusion process. It associated deterioration reproductive function woman. Despite significant correlation uterine development abnormalities infertility and miscarriage, this article demonstrates both functional bodies complete doubling. And second pregnancy was hemiuterus presence scar from perforation right body. should also be noted that pregnancies occurred naturally. Conclusion. This possibility spontaneous occurrence termination favorable maternal perinatal outcomes women words: doubling uterus, function, cesarean section.

Language: Английский

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