Hyperleptinemia as a Marker of Various Phenotypes of Obesity and Overweight in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus

Doklady Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 517(1), P. 182 - 194

Published: June 10, 2024

Language: Английский

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Changes of carbohydrate metabolism and insulin resistance parameters at different compliance levels in young people

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2024, Volume and Issue: 23(6), P. 4059 - 4059

Published: June 7, 2024

Aim . To analyze early disorders of carbohydrate metabolism and insulin resistance (IR) at different compliance levels in young people. Material methods Ninety-four patients (45 men/49 women; median (Me)=33 [28,7-38] years) were examined. This prospective observational study used data the questionnaire quantitative assessment adherence to treatment (QAA-25), fasting plas­ma glucose levels, oral tolerance test, glycated hemo­globin (HbA 1c ), Homeostasis Model Assessment Insulin Resistance (HOMA-IR). Statistical processing was carried out IBM SPSS Statistics 26. Results Only 15,8% had high medical support, 8,9% — lifestyle modification (LM) general compliance, 10,9% drug therapy. The means for most types adherences low range. In medium LM groups, over 18 months number with elevated HbA increased from 7,1 18,8% (p=0,021) IR 12% 31,8% (p=0,000). overall compared ones, probability increase raised by 5,5 times, hyperinsulinemia 1,16 times. Conclusion an 18-month study, adults showed incidence hyper­insulinemia, IR, prediabetes.

Language: Английский

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Ectopic adipose tissue: association of obesity phenotypes with integral metabolic indices of obesity

Rational Pharmacotherapy in Cardiology, Journal Year: 2024, Volume and Issue: 20(3), P. 285 - 293

Published: June 19, 2024

Aim . To study the relationship and predictive value of integral metabolic indices obesity in identification ectopic obesity. Material methods The included 326 patients (146 men 180 women, mean age 61±9 years). Anthropometric data, degree obesity, body mass index (BMI), waist circumference (WC), sagittal abdominal diameter (SAD), (BAI), visceral (VAI), lipid accumulation (LAP), triglycerides-glucose (TyG) was assessed. Perivascular adipose tissue (PVAT) volume, pericardial (PAT) volume thickness perirenal fat (PRF) were assessed with CT. Results Patients divided into groups: isolated (iEO) (n=17); (iAO) (n=74); EO variants: (PCO) (n=31), perivascular (PVO) (n=22) or (PRO) (n=33) AO; mixed AO (mEO+AO) (n=117), without (n=32). Significantly higher BMI, WC, SAD, BAI found individuals PCO+AO, PRO+AO mEO+AO. highest values LAP PVO+AO, PRO+AO. There a correlation between depots WC (r=0,62 for PAT, r=0,55 PVAT r=0,39 PRF, p=0,01) SAD (0,429, 0,329 0,435, respectively, p=0,01). Correlation established PRF (0,425 0,319, AUC values>0,8 had models PCO (0,801 0,801, respectively) PRO (0,826 0,826, respectively). For PCO, cut-off point 100,5 cm (specificity 72,9%, sensitivity 70,2%, p=0,000), — 25 73%, p=0,000). PRO, 101 71,4%, 72,7%, Conclusion Еctopic are related to risk disorders. Potential informative simple accessible established. WC>100,5 cm, SAD>25 may indicate presence PCO; WC>101 PRO.

Language: Английский

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Threonine In Different Phenotypes Of Chronic Heart Failure With Preserved Ejection Fraction

Russian Open Medical Journal, Journal Year: 2024, Volume and Issue: 13(3)

Published: Sept. 30, 2024

Background — Chronic heart failure with preserved ejection fraction (CHFpEF) develops as a result of many diseases that lead to significant metabolic disorders. Given the heterogeneity this group patients, therapeutic options for syndrome are extremely limited. In regard, it seems promising study metabolomic profile in patients CHFpEF identify biomarkers, examine their roles pathogenesis syndrome, and search potential targets targeted therapy. Objective The aimed at testing correlation between threonine level features clinical course CHFpEF. Methods included total 154 patients: 82 CHFpEF, 45 hypertension and/or coronary artery disease (comparison group), 27 healthy volunteers (control group). Threonine levels were assessed using high-performance liquid chromatography-mass spectrometry. Results concentration was significantly reduced (1) vs. comparison (2) control (3): p<0.001; p1-3<0.001; p2-3=0.037). A reduction characteristic diabetes mellitus without (p=0.029). Conclusion importance energy metabolism changes its various pathophysiological processes, should be considered an additional diagnostic prognostic criterion Additional studies needed better understand role pathophysiology cardiovascular diseases.

Language: Английский

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Primary and residual cardiometabolic risk factors among young adults in a Russian city

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Oct. 23, 2024

Cardiovascular diseases are a leading cause of mortality and significant contributor to temporary permanent disabilities worldwide. This study aimed investigate the burden primary residual cardiometabolic risk factors in sample young adults Russian city Kazan. case-control used Cardiometabolic Disease Staging (CMDS) classification system, which has been validated several countries. The included 191 individuals aged 25–44 years who met inclusion criteria but did not meet any exclusion criteria. Data collection involved patient card with questions from World Health Organization's STEPS instrument, face-to-face interviews, physical examination. Anthropometric assessments height, weight, waist circumference measurements. Body composition was evaluated using bioelectrical impedance Patients also underwent in-depth laboratory biochemical analyses. cohort comprised 97 females (50.8%) 94 males (49.2%). median age participants 35.00 [IQR: 30.00–39.00]. showed an increase all anthropometric parameters, abdominal obesity overweight reaching 100% CMDS 3. Apart atherogenic lipids raised blood pressure, other that precipitate were part CMDS, such as insulin levels, resistance, leptin values, hyperuricemia, increased levels increased. prevalence high highlights need for early identification management prevent development cardiovascular later life.

Language: Английский

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